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Items: 1 to 20 of 117


Expeditious Green Synthesis of Novel 4-Methyl-1,2,5,6-tetraazafluoranthen-3(2H)-one Analogue from Ninhydrin: N/S-Alkylation and Aza-Michael Addition.

Boraei ATA, Ghabbour HA, Sarhan AAM, Barakat A.

ACS Omega. 2020 Mar 3;5(10):5436-5442. doi: 10.1021/acsomega.0c00045. eCollection 2020 Mar 17.


Synthesis and crystal structure of 3-(adamantan-1-yl)-4-(2-bromo-4-fluoro-phen-yl)-1H-1,2,4-triazole-5(4H)-thione.

Abdelrazeq AS, Ghabbour HA, El-Emam AA, Osman DA, Garcia-Granda S.

Acta Crystallogr E Crystallogr Commun. 2020 Jan 10;76(Pt 2):162-166. doi: 10.1107/S2056989020000092. eCollection 2020 Feb 1.


Synthesis and Anti-Proliferative Assessment of Triazolo-Thiadiazepine and Triazolo-Thiadiazine Scaffolds.

Boraei ATA, Ghabbour HA, Gomaa MS, El Ashry ESH, Barakat A.

Molecules. 2019 Dec 6;24(24). pii: E4471. doi: 10.3390/molecules24244471.


A Simple, Efficient, and Eco-Friendly Method for the Preparation of 3-Substituted-2,3-dihydroquinazolin-4(1H)-one Derivatives.

Almarhoon Z, Dahlous KA, Abd Alhameed R, Ghabbour HA, El-Faham A.

Molecules. 2019 Nov 9;24(22). pii: E4052. doi: 10.3390/molecules24224052.


Synthesis and Inhibitory Effect of Some Indole-Pyrimidine Based Hybrid Heterocycles on α-Glucosidase and α-Amylase as Potential Hypoglycemic Agents.

Badria FA, Atef S, Al-Majid AM, Ali M, Elshaier YAMM, Ghabbour HA, Islam MS, Barakat A.

ChemistryOpen. 2019 Oct 22;8(10):1288-1297. doi: 10.1002/open.201900240. eCollection 2019 Oct.


Anticancer Indole-Based Chalcones: A Structural and Theoretical Analysis.

Badria FA, Soliman SM, Atef S, Islam MS, Al-Majid AM, Dege N, Ghabbour HA, Ali M, El-Senduny FF, Barakat A.

Molecules. 2019 Oct 16;24(20). pii: E3728. doi: 10.3390/molecules24203728.


The novel economical synthesis and antimicrobial activity of a trithiocarbonate derivative.

Mabkhot YN, Khaled JMA, Sultan MAS, Alharbi NSHA, Al-Showiman SS, Ghabbour HA, Alsayari A, Muhsinah AB, Algarni H.

Bioorg Chem. 2019 Oct;91:103157. doi: 10.1016/j.bioorg.2019.103157. Epub 2019 Jul 29.


Vibrational spectral analysis, XRD-structure, computation, exo⇔endo isomerization and non-linear optical crystal of 5-((5-chloro-1H-indol-2-yl)methylene)-1,3-diethyl-2-thioxodihy-dropyrimidine-4,6 (1H,5H)-dione.

Altowyan MS, Barakat A, Al-Majid AM, Ghabbour HA, Zarrouk A, Warad I.

BMC Chem. 2019 Feb 2;13(1):11. doi: 10.1186/s13065-019-0524-8. eCollection 2019 Dec.


Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole-imidazole molecular hybrids bearing ester functionalities.

Al-Wabli RI, Al-Ghamdi AR, Ghabbour HA, Al-Agamy MH, Attia MI.

Drug Des Devel Ther. 2019 Feb 26;13:775-789. doi: 10.2147/DDDT.S199135. eCollection 2019.


Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2-p53 interaction.

Barakat A, Islam MS, Ghawas HM, Al-Majid AM, El-Senduny FF, Badria FA, Elshaier YAMM, Ghabbour HA.

Bioorg Chem. 2019 May;86:598-608. doi: 10.1016/j.bioorg.2019.01.053. Epub 2019 Jan 31.


Effect of hydroxylated solvents on the active constituents of Salvadora persica root "Siwak".

Abdel-Kader MS, Al Shahrani KS, Alqarni MH, Salkini MA, Khamis EH, Ghabbour HA, Alqasoumi SI.

Saudi Pharm J. 2019 Feb;27(2):220-224. doi: 10.1016/j.jsps.2018.11.001. Epub 2018 Nov 8.


Synthesis and Molecular Docking of New Thiophene Derivatives as Lactate Dehydrogenase-A Inhibitors.

Amr AEE, El-Shehry MF, Ibrahim AA, Hosni HM, Al-Omar MA, Ghabbour HA.

Mini Rev Med Chem. 2019;19(10):833-841. doi: 10.2174/1389557519666190212165302.


Synthesis and Spectroscopic Identification of Certain Imidazole-Semicarbazone Conjugates Bearing Benzodioxole Moieties: New Antifungal Agents.

Al-Wabli RI, Al-Ghamdi AR, Ghabbour HA, Al-Agamy MH, Attia MI.

Molecules. 2019 Jan 7;24(1). pii: E200. doi: 10.3390/molecules24010200.


One-pot synthesis of spiro(indoline-3,4'-pyrazolo[3,4-b]pyridine)-5'-carbonitriles as p53-MDM2 interaction inhibitors.

Ibrahim HS, Eldehna WM, Fallacara AL, Ahmed ER, Ghabbour HA, Elaasser MM, Botta M, Abou-Seri SM, Abdel-Aziz HA.

Future Med Chem. 2018 Dec;10(24):2771-2789. doi: 10.4155/fmc-2018-0288. Epub 2018 Dec 10.


SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX.

Eldehna WM, Abo-Ashour MF, Berrino E, Vullo D, Ghabbour HA, Al-Rashood ST, Hassan GS, Alkahtani HM, Almehizia AA, Alharbi A, Abdel-Aziz HA, Supuran CT.

Bioorg Chem. 2019 Mar;83:549-558. doi: 10.1016/j.bioorg.2018.11.014. Epub 2018 Nov 14.


Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells.

Ismail RSM, Abou-Seri SM, Eldehna WM, Ismail NSM, Elgazwi SM, Ghabbour HA, Ahmed MS, Halaweish FT, Abou El Ella DA.

Eur J Med Chem. 2018 Jul 15;155:782-796. doi: 10.1016/j.ejmech.2018.06.024. Epub 2018 Jun 19.


A One-Pot Biginelli Synthesis and Characterization of Novel Dihydropyrimidinone Derivatives Containing Piperazine/Morpholine Moiety.

Bhat MA, Al-Omar MA, Ghabbour HA, Naglah AM.

Molecules. 2018 Jun 27;23(7). pii: E1559. doi: 10.3390/molecules23071559.


Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents.

Mabkhot YN, Alharbi MM, Al-Showiman SS, Ghabbour HA, Kheder NA, Soliman SM, Frey W.

Chem Cent J. 2018 May 11;12(1):56. doi: 10.1186/s13065-018-0420-7.


Synthesis, Crystal Structure and DFT Studies of a New Dinuclear Ag(I)-Malonamide Complex.

Soliman SM, Barakat A, Islam MS, Ghabbour HA.

Molecules. 2018 Apr 11;23(4). pii: E888. doi: 10.3390/molecules23040888.


Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation.

Eldehna WM, Abo-Ashour MF, Ibrahim HS, Al-Ansary GH, Ghabbour HA, Elaasser MM, Ahmed HYA, Safwat NA.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):686-700. doi: 10.1080/14756366.2017.1421181.

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