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Items: 1 to 20 of 81

1.

Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome.

Thirumal Kumar D, Udhaya Kumar S, Nishaat Laeeque AS, Apurva Abhay S, Bithia R, Magesh R, Kumar M, Zayed H, George Priya Doss C.

Adv Protein Chem Struct Biol. 2020;120:379-408. doi: 10.1016/bs.apcsb.2019.11.005. Epub 2020 Feb 4.

PMID:
32085886
2.

Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene.

Udhaya Kumar S, Thirumal Kumar D, Mandal PD, Sankar S, Haldar R, Kamaraj B, Walter CEJ, Siva R, George Priya Doss C, Zayed H.

Adv Protein Chem Struct Biol. 2020;120:349-377. doi: 10.1016/bs.apcsb.2019.11.004. Epub 2020 Feb 4.

PMID:
32085885
3.

An extensive computational approach to analyze and characterize the functional mutations in the galactose-1-phosphate uridyl transferase (GALT) protein responsible for classical galactosemia.

Kumar S U, Kumar D T, R S, Doss C GP, Zayed H.

Comput Biol Med. 2020 Feb;117:103583. doi: 10.1016/j.compbiomed.2019.103583. Epub 2019 Dec 13.

PMID:
32072977
4.

CD44 mediates stem cell mobilization to damaged lung via its novel transcriptional targets, Cortactin and Survivin.

Ouhtit A, Thouta R, Zayed H, Gaur RL, Fernando A, Rahman M, Welsh DA.

Int J Med Sci. 2020 Jan 1;17(1):103-111. doi: 10.7150/ijms.33125. eCollection 2020.

5.

Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer.

Kumar SU, Kumar DT, Siva R, Doss CGP, Zayed H.

Front Bioeng Biotechnol. 2019 Dec 17;7:391. doi: 10.3389/fbioe.2019.00391. eCollection 2019.

6.

Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach.

Thirumal Kumar D, Jain N, Udhaya Kumar S, George Priya Doss C, Zayed H.

J Biomol Struct Dyn. 2020 Jan 6:1-17. doi: 10.1080/07391102.2019.1708797. [Epub ahead of print]

PMID:
31870226
7.

Genetic Epidemiology of Hearing Loss in the 22 Arab Countries: A Systematic Review.

Sidenna M, Fadl T, Zayed H.

Otol Neurotol. 2020 Feb;41(2):e152-e162. doi: 10.1097/MAO.0000000000002489.

PMID:
31860473
8.

A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation causing breast cancer.

Thirumal Kumar D, Jain N, Evangeline J, Kamaraj B, Siva R, Zayed H, George Priya Doss C.

Comput Biol Med. 2019 Dec;115:103513. doi: 10.1016/j.compbiomed.2019.103513. Epub 2019 Oct 21.

PMID:
31698236
9.

Immunogenetics of Celiac Disease: A focus on Arab countries.

Younes N, Younes S, Alsharabasi OA, El Zowalaty ME, Mustafa I, Jahromi M, Uddin S, Al-Nesf M, Pintus G, Zayed H.

Curr Mol Med. 2019 Oct 23. doi: 10.2174/1566524019666191024104930. [Epub ahead of print]

PMID:
31659945
10.

Association of genetic variants with colorectal cancer in the extended MENA region: A systematic review.

Sidenna M, Bux R, Fadl T, Ozbek U, Zayed H.

Curr Mol Med. 2019 Oct 14. doi: 10.2174/1566524019666191014170136. [Epub ahead of print]

PMID:
31612830
11.

Bioinformatics classification of mutations in patients with Mucopolysaccharidosis IIIA.

Tanwar H, Kumar DT, Doss CGP, Zayed H.

Metab Brain Dis. 2019 Dec;34(6):1577-1594. doi: 10.1007/s11011-019-00465-6. Epub 2019 Aug 5.

12.

The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer.

Siveen KS, Raza A, Ahmed EI, Khan AQ, Prabhu KS, Kuttikrishnan S, Mateo JM, Zayed H, Rasul K, Azizi F, Dermime S, Steinhoff M, Uddin S.

Cancers (Basel). 2019 May 29;11(6). pii: E746. doi: 10.3390/cancers11060746. Review.

13.

An integrative bioinformatics pipeline to demonstrate the alteration of the interaction between the ALDH2*2 allele with NAD+ and Disulfiram.

J CP, D TK, P S, R S, W CEJ, C GPD, Zayed H.

J Cell Biochem. 2019 Oct;120(10):17030-17041. doi: 10.1002/jcb.28964. Epub 2019 May 19.

PMID:
31104322
14.

Clinical, biochemical, neuroradiological and molecular characterization of Egyptian patients with glutaric acidemia type 1.

Zayed H, El Khayat H, Tomoum H, Khalifa O, Siddiq E, Mohammad SA, Gamal R, Shi Z, Mosailhy A, Zaki OK.

Metab Brain Dis. 2019 Aug;34(4):1231-1241. doi: 10.1007/s11011-019-00422-3. Epub 2019 May 6.

15.

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling.

Akhtar S, Achkar IW, Siveen KS, Kuttikrishnan S, Prabhu KS, Khan AQ, Ahmed EI, Sahir F, Jerobin J, Raza A, Merhi M, Elsabah HM, Taha R, Omri HE, Zayed H, Dermime S, Steinhoff M, Uddin S.

Front Oncol. 2019 Apr 17;9:285. doi: 10.3389/fonc.2019.00285. eCollection 2019.

16.

Genetic polymorphisms associated with type 2 diabetes in the Arab world: A systematic review and meta-analysis.

Abuhendi N, Qush A, Naji F, Abunada H, Al Buainain R, Shi Z, Zayed H.

Diabetes Res Clin Pract. 2019 May;151:198-208. doi: 10.1016/j.diabres.2019.03.037. Epub 2019 Apr 4.

PMID:
30954515
17.

Molecular insights of the G2019S substitution in LRRK2 kinase domain associated with Parkinson's disease: A molecular dynamics simulation approach.

Agrahari AK, Doss GPC, Siva R, Magesh R, Zayed H.

J Theor Biol. 2019 May 21;469:163-171. doi: 10.1016/j.jtbi.2019.03.003. Epub 2019 Mar 4.

PMID:
30844370
18.

Understanding the structure-function relationship of HPRT1 missense mutations in association with Lesch-Nyhan disease and HPRT1-related gout by in silico mutational analysis.

Agrahari AK, Krishna Priya M, Praveen Kumar M, Tayubi IA, Siva R, Prabhu Christopher B, George Priya Doss C, Zayed H.

Comput Biol Med. 2019 Apr;107:161-171. doi: 10.1016/j.compbiomed.2019.02.014. Epub 2019 Feb 23.

PMID:
30831305
19.

A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase.

Thirumal Kumar D, Mendonca E, Priyadharshini Christy J, George Priya Doss C, Zayed H.

Adv Protein Chem Struct Biol. 2019;115:351-369. doi: 10.1016/bs.apcsb.2018.11.006. Epub 2019 Jan 7. Review.

PMID:
30798937
20.

Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach.

Thirumal Kumar D, Susmita B, Judith E, Priyadharshini Christy J, George Priya Doss C, Zayed H.

Adv Protein Chem Struct Biol. 2019;115:325-350. doi: 10.1016/bs.apcsb.2018.11.005. Epub 2019 Jan 7. Review.

PMID:
30798936

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