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Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion.

Jansen J, Jansen K, Neven E, Poesen R, Othman A, van Mil A, Sluijter J, Sastre Torano J, Zaal EA, Berkers CR, Esser D, Wichers HJ, van Ede K, van Duursen M, Burtey S, Verhaar MC, Meijers B, Masereeuw R.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16105-16110. doi: 10.1073/pnas.1821809116. Epub 2019 Jul 24.


Differential Effects of Dry vs. Wet Heating of β-Lactoglobulin on Formation of sRAGE Binding Ligands and sIgE Epitope Recognition.

Zenker HE, Ewaz A, Deng Y, Savelkoul HFJ, van Neerven RJJ, De Jong NW, Wichers HJ, Hettinga KA, Teodorowicz M.

Nutrients. 2019 Jun 25;11(6). pii: E1432. doi: 10.3390/nu11061432.


Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy.

Hoppenbrouwers T, Cvejić Hogervorst JH, Garssen J, Wichers HJ, Willemsen LEM.

Front Immunol. 2019 May 22;10:1118. doi: 10.3389/fimmu.2019.01118. eCollection 2019. Review.


Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients.

Jochems PGM, van Bergenhenegouwen J, van Genderen AM, Eis ST, Wilod Versprille LJF, Wichers HJ, Jeurink PV, Garssen J, Masereeuw R.

Toxicol In Vitro. 2019 Oct;60:1-11. doi: 10.1016/j.tiv.2019.04.019. Epub 2019 May 6.


Hydrophobicity and aggregation, but not glycation, are key determinants for uptake of thermally processed β-lactoglobulin by THP-1 macrophages.

Deng Y, Govers C, Bastiaan-Net S, van der Hulst N, Hettinga K, Wichers HJ.

Food Res Int. 2019 Jun;120:102-113. doi: 10.1016/j.foodres.2019.01.038. Epub 2019 Jan 22.


IgE Cross-Reactivity of Cashew Nut Allergens.

Bastiaan-Net S, Reitsma M, Cordewener JHG, van der Valk JPM, America TAHP, Dubois AEJ, Gerth van Wijk R, Savelkoul HFJ, de Jong NW, Wichers HJ.

Int Arch Allergy Immunol. 2019;178(1):19-32. doi: 10.1159/000493100. Epub 2018 Oct 26.


Immunomodulation by Processed Animal Feed: The Role of Maillard Reaction Products and Advanced Glycation End-Products (AGEs).

Teodorowicz M, Hendriks WH, Wichers HJ, Savelkoul HFJ.

Front Immunol. 2018 Sep 13;9:2088. doi: 10.3389/fimmu.2018.02088. eCollection 2018. Review.


Consumption of β-glucans to spice up T cell treatment of tumors: a review.

de Graaff P, Govers C, Wichers HJ, Debets R.

Expert Opin Biol Ther. 2018 Oct;18(10):1023-1040. doi: 10.1080/14712598.2018.1523392. Review.


Release of Major Peanut Allergens from Their Matrix under Various pH and Simulated Saliva Conditions-Ara h2 and Ara h6 Are Readily Bio-Accessible.

Koppelman SJ, Smits M, Tomassen M, de Jong GAH, Baumert J, Taylor SL, Witkamp R, Veldman RJ, Pieters R, Wichers H.

Nutrients. 2018 Sep 11;10(9). pii: E1281. doi: 10.3390/nu10091281.


Lactobacillus acidophilus Attenuates Salmonella-Induced Stress of Epithelial Cells by Modulating Tight-Junction Genes and Cytokine Responses.

Lépine AFP, de Wit N, Oosterink E, Wichers H, Mes J, de Vos P.

Front Microbiol. 2018 Jul 2;9:1439. doi: 10.3389/fmicb.2018.01439. eCollection 2018.


THP-1 and U937 Cells.

Chanput W, Peters V, Wichers H.

In: Verhoeckx K, Cotter P, López-Expósito I, Kleiveland C, Lea T, Mackie A, Requena T, Swiatecka D, Wichers H, editors. The Impact of Food Bioactives on Health: in vitro and ex vivo models [Internet]. Cham (CH): Springer; 2015. Chapter 14.


The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2.

Arena MP, Govers C, Lotti C, Ricciardi L, Wichers HJ, Mes JJ.

Molecules. 2018 Mar 13;23(3). pii: E644. doi: 10.3390/molecules23030644.


Origin and Processing Methods Slightly Affect Allergenic Characteristics of Cashew Nuts (Anacardium occidentale).

Reitsma M, Bastiaan-Net S, Sijbrandij L, de Weert E, Sforza S, Gerth van Wijk R, Savelkoul HFJ, de Jong NW, Wichers HJ.

J Food Sci. 2018 Apr;83(4):1153-1164. doi: 10.1111/1750-3841.14003. Epub 2018 Mar 10.


Water-Soluble Polysaccharide Extracts from the Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory Activity.

Gil-Ramirez A, Smiderle FR, Morales D, Govers C, Synytsya A, Wichers HJ, Iacomini M, Soler-Rivas C.

Int J Med Mushrooms. 2017;19(10):879-892. doi: 10.1615/IntJMedMushrooms.2017024413.


Mitochondrial ATP Depletion Disrupts Caco-2 Monolayer Integrity and Internalizes Claudin 7.

JanssenDuijghuijsen LM, Grefte S, de Boer VCJ, Zeper L, van Dartel DAM, van der Stelt I, Bekkenkamp-Grovenstein M, van Norren K, Wichers HJ, Keijer J.

Front Physiol. 2017 Oct 11;8:794. doi: 10.3389/fphys.2017.00794. eCollection 2017.


Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins.

Lai X, Wichers HJ, Soler-Lopez M, Dijkstra BW.

Chemistry. 2018 Jan 2;24(1):47-55. doi: 10.1002/chem.201704410. Epub 2017 Nov 28. Review.


Small percentage of anaphylactic reactions treated with epinephrine during food challenges in Dutch children.

van der Valk JPM, Berends I, Gerth van Wijk R, Arends NJT, van Maaren MS, de Groot H, Wichers HJ, Emons JAM, Dubois AEJ, de Jong NW.

Ann Allergy Asthma Immunol. 2018 Mar;120(3):300-303. doi: 10.1016/j.anai.2017.08.018. Epub 2017 Oct 7.


Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.

Lai X, Wichers HJ, Soler-Lopez M, Dijkstra BW.

Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9812-9815. doi: 10.1002/anie.201704616. Epub 2017 Jul 17.


Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins.

van Bilsen JHM, Sienkiewicz-Szłapka E, Lozano-Ojalvo D, Willemsen LEM, Antunes CM, Molina E, Smit JJ, Wróblewska B, Wichers HJ, Knol EF, Ladics GS, Pieters RHH, Denery-Papini S, Vissers YM, Bavaro SL, Larré C, Verhoeckx KCM, Roggen EL.

Clin Transl Allergy. 2017 May 12;7:13. doi: 10.1186/s13601-017-0152-0. eCollection 2017. Review.


Prediction of cashew nut allergy in sensitized children.

van der Valk JPM, Vergouwe Y, Gerth van Wijk R, Steyerberg EW, Reitsma M, Wichers HJ, Savelkoul HFJ, Vlieg-Boerstra B, de Groot H, Dubois AEJ, de Jong NW.

Pediatr Allergy Immunol. 2017 Aug;28(5):487-490. doi: 10.1111/pai.12726. Epub 2017 Jun 14. No abstract available.


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