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Items: 1 to 20 of 21


Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells.

Sirenko SG, Maltsev VA, Yaniv Y, Bychkov R, Yaeger D, Vinogradova T, Spurgeon HA, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H251-67. doi: 10.1152/ajpheart.00667.2015. Epub 2016 May 20.


Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells.

Monfredi O, Maltseva LA, Spurgeon HA, Boyett MR, Lakatta EG, Maltsev VA.

PLoS One. 2013 Jun 27;8(6):e67247. doi: 10.1371/journal.pone.0067247. Print 2013.


New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.

Yaniv Y, Sirenko S, Ziman BD, Spurgeon HA, Maltsev VA, Lakatta EG.

J Mol Cell Cardiol. 2013 Sep;62:80-9. doi: 10.1016/j.yjmcc.2013.04.026. Epub 2013 May 5.


Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand.

Yaniv Y, Spurgeon HA, Ziman BD, Lyashkov AE, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2013 Jun 1;304(11):H1428-38. doi: 10.1152/ajpheart.00969.2012. Epub 2013 Apr 19.


Ca²+/calmodulin-dependent protein kinase II (CaMKII) activity and sinoatrial nodal pacemaker cell energetics.

Yaniv Y, Spurgeon HA, Ziman BD, Lakatta EG.

PLoS One. 2013;8(2):e57079. doi: 10.1371/journal.pone.0057079. Epub 2013 Feb 25.


The "funny" current (I(f)) inhibition by ivabradine at membrane potentials encompassing spontaneous depolarization in pacemaker cells.

Yaniv Y, Maltsev VA, Ziman BD, Spurgeon HA, Lakatta EG.

Molecules. 2012 Jul 9;17(7):8241-54. doi: 10.3390/molecules17078241.


Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.

Yaniv Y, Spurgeon HA, Lyashkov AE, Yang D, Ziman BD, Maltsev VA, Lakatta EG.

PLoS One. 2012;7(5):e37582. doi: 10.1371/journal.pone.0037582. Epub 2012 May 29.


Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm.

Yaniv Y, Maltsev VA, Escobar AL, Spurgeon HA, Ziman BD, Stern MD, Lakatta EG.

J Mol Cell Cardiol. 2011 Dec;51(6):902-5. doi: 10.1016/j.yjmcc.2011.08.029. Epub 2011 Sep 14.


A full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling.

Liu J, Sirenko S, Juhaszova M, Ziman B, Shetty V, Rain S, Shukla S, Spurgeon HA, Vinogradova TM, Maltsev VA, Lakatta EG.

J Mol Cell Cardiol. 2011 Nov;51(5):730-9. doi: 10.1016/j.yjmcc.2011.07.028. Epub 2011 Aug 4.


Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand.

Yaniv Y, Juhaszova M, Lyashkov AE, Spurgeon HA, Sollott SJ, Lakatta EG.

J Mol Cell Cardiol. 2011 Nov;51(5):740-8. doi: 10.1016/j.yjmcc.2011.07.018. Epub 2011 Jul 28.


Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling.

Zahanich I, Sirenko SG, Maltseva LA, Tarasova YS, Spurgeon HA, Boheler KR, Stern MD, Lakatta EG, Maltsev VA.

J Mol Cell Cardiol. 2011 Jan;50(1):66-76. doi: 10.1016/j.yjmcc.2010.09.018. Epub 2010 Oct 15.


Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study.

Wang KL, Cheng HM, Sung SH, Chuang SY, Li CH, Spurgeon HA, Ting CT, Najjar SS, Lakatta EG, Yin FC, Chou P, Chen CH.

Hypertension. 2010 Mar;55(3):799-805. doi: 10.1161/HYPERTENSIONAHA.109.139964. Epub 2010 Jan 11.


Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).

Lyashkov AE, Vinogradova TM, Zahanich I, Li Y, Younes A, Nuss HB, Spurgeon HA, Maltsev VA, Lakatta EG.

Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H949-59. doi: 10.1152/ajpheart.01340.2008. Epub 2009 Jun 19.


Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality?

Wang KL, Cheng HM, Chuang SY, Spurgeon HA, Ting CT, Lakatta EG, Yin FC, Chou P, Chen CH.

J Hypertens. 2009 Mar;27(3):461-7.


Do hypertensive individuals have enlarged aortic root diameters? Insights from studying the various subtypes of hypertension.

Farasat SM, Morrell CH, Scuteri A, Ting CT, C P Yin F, Spurgeon HA, Chen CH, G Lakatta E, Najjar SS.

Am J Hypertens. 2008 May;21(5):558-63. doi: 10.1038/ajh.2008.10. Epub 2008 Feb 28.


Pulse pressure is inversely related to aortic root diameter implications for the pathogenesis of systolic hypertension.

Farasat SM, Morrell CH, Scuteri A, Ting CT, Yin FC, Spurgeon HA, Chen CH, Lakatta EG, Najjar SS.

Hypertension. 2008 Feb;51(2):196-202. Epub 2007 Dec 24.


Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size.

Lyashkov AE, Juhaszova M, Dobrzynski H, Vinogradova TM, Maltsev VA, Juhasz O, Spurgeon HA, Sollott SJ, Lakatta EG.

Circ Res. 2007 Jun 22;100(12):1723-31. Epub 2007 May 24.


Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state.

Bogdanov KY, Maltsev VA, Vinogradova TM, Lyashkov AE, Spurgeon HA, Stern MD, Lakatta EG.

Circ Res. 2006 Oct 27;99(9):979-87. Epub 2006 Sep 28.


Walking may be related to less vascular stiffness in the Activity Counseling Trial (ACT).

Havlik RJ, Phillips CL, Brock DB, Lohman K, Haskell W, Snell P, O'Toole M, Ribisl P, Vaitkevicius P, Spurgeon HA, Lakatta EG, Pullen P.

Am Heart J. 2005 Aug;150(2):270-5.


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