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Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018.

Genth H, Junemann J, Lämmerhirt CM, Lücke AC, Schelle I, Just I, Gerhard R, Pich A.

Front Microbiol. 2018 Dec 21;9:3078. doi: 10.3389/fmicb.2018.03078. eCollection 2018.


Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B.

Schöttelndreier D, Seeger K, Grassl GA, Winny MR, Lindner R, Genth H.

Front Microbiol. 2018 Jul 4;9:1483. doi: 10.3389/fmicb.2018.01483. eCollection 2018.


Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways.

Zhao T, Li R, Tan X, Zhang J, Fan C, Zhao Q, Deng Y, Xu A, Lukong KE, Genth H, Xiang J.

Int J Mol Sci. 2018 Jul 8;19(7). pii: E1994. doi: 10.3390/ijms19071994.


Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways.

Tan X, Xu A, Zhao T, Zhao Q, Zhang J, Fan C, Deng Y, Freywald A, Genth H, Xiang J.

Sci Rep. 2018 Feb 28;8(1):3769. doi: 10.1038/s41598-018-20459-1.


Quantification of small GTPase glucosylation by clostridial glucosylating toxins using multiplexed MRM analysis.

Junemann J, Lämmerhirt CM, Polten F, Just I, Gerhard R, Genth H, Pich A.

Proteomics. 2017 May;17(9). doi: 10.1002/pmic.201700016.


Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.

Schelle I, Bruening J, Buetepage M, Genth H.

Toxins (Basel). 2016 Dec 22;9(1). pii: E2. doi: 10.3390/toxins9010002.


Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells.

Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D.

Exp Dermatol. 2017 Jan;26(1):44-50. doi: 10.1111/exd.13118.


Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.

Genth H, Schelle I, Just I.

Toxins (Basel). 2016 Apr 13;8(4):109. doi: 10.3390/toxins8040109.


DXD motif-dependent and -independent effects of the chlamydia trachomatis cytotoxin CT166.

Bothe M, Dutow P, Pich A, Genth H, Klos A.

Toxins (Basel). 2015 Feb 17;7(2):621-37. doi: 10.3390/toxins7020621.


UV radiation induces CXCL5 expression in human skin.

Reichert O, Kolbe L, Terstegen L, Staeb F, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G.

Exp Dermatol. 2015 Apr;24(4):309-12. doi: 10.1111/exd.12652.


Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells.

Keller B, Mühlenkamp M, Deuschle E, Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jiménez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E.

Cell Microbiol. 2015 Aug;17(8):1179-204. doi: 10.1111/cmi.12429. Epub 2015 Mar 20.


Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

Genth H, Pauillac S, Schelle I, Bouvet P, Bouchier C, Varela-Chavez C, Just I, Popoff MR.

Cell Microbiol. 2014 Nov;16(11):1706-21. doi: 10.1111/cmi.12321. Epub 2014 Aug 4.


Pyknotic cell death induced by Clostridium difficile TcdB: chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity.

Wohlan K, Goy S, Olling A, Srivaratharajan S, Tatge H, Genth H, Gerhard R.

Cell Microbiol. 2014 Nov;16(11):1678-92. doi: 10.1111/cmi.12317. Epub 2014 Aug 4.


Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry.

May M, Schelle I, Brakebusch C, Rottner K, Genth H.

Cell Cycle. 2014;13(14):2211-21. doi: 10.4161/cc.29279. Epub 2014 May 19.


The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases.

Schweer J, Kulkarni D, Kochut A, Pezoldt J, Pisano F, Pils MC, Genth H, Huehn J, Dersch P.

PLoS Pathog. 2013;9(11):e1003746. doi: 10.1371/journal.ppat.1003746. Epub 2013 Nov 7.


Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1.

Huelsenbeck SC, Roggenkamp D, May M, Huelsenbeck J, Brakebusch C, Rottner K, Ladwein M, Just I, Fritz G, Schmidt G, Genth H.

Int J Biochem Cell Biol. 2013 Aug;45(8):1767-75. doi: 10.1016/j.biocel.2013.05.020. Epub 2013 May 31.


Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.

Huelsenbeck J, May M, Schulz F, Schelle I, Ronkina N, Hohenegger M, Fritz G, Just I, Gerhard R, Genth H.

FEBS Lett. 2012 Oct 19;586(20):3665-73. doi: 10.1016/j.febslet.2012.08.024. Epub 2012 Sep 11.


Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis.

May M, Kolbe T, Wang T, Schmidt G, Genth H.

J Signal Transduct. 2012;2012:570183. doi: 10.1155/2012/570183. Epub 2012 Jul 5.


Inhibition of macrophage migration by C. botulinum exoenzyme C3.

Rotsch J, Rohrbeck A, May M, Kolbe T, Hagemann S, Schelle I, Just I, Genth H, Huelsenbeck SC.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Sep;385(9):883-90. doi: 10.1007/s00210-012-0764-9. Epub 2012 May 29.


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