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Items: 1 to 20 of 55

1.

Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage.

Kahremany S, Babaev I, Gvirtz R, Ogen-Stern N, Azoulay-Ginsburg S, Senderowitz H, Cohen G, Gruzman A.

Skin Pharmacol Physiol. 2019;32(4):173-181. doi: 10.1159/000499432. Epub 2019 May 10.

PMID:
31079103
2.

Hsp104 facilitates the endoplasmic-reticulum-associated degradation of disease-associated and aggregation-prone substrates.

Doonan LM, Guerriero CJ, Preston GM, Buck TM, Khazanov N, Fisher EA, Senderowitz H, Brodsky JL.

Protein Sci. 2019 Jul;28(7):1290-1306. doi: 10.1002/pro.3636. Epub 2019 May 20.

PMID:
31050848
3.

Materials Informatics.

Senderowitz H, Tropsha A.

J Chem Inf Model. 2018 Dec 24;58(12):2377-2379. doi: 10.1021/acs.jcim.8b00927. No abstract available.

PMID:
30990041
4.

Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions.

Munder A, Moskovitz Y, Meir A, Kahremany S, Levy L, Kolitz-Domb M, Cohen G, Shtriker E, Viskind O, Lellouche JP, Senderowitz H, Chessler SD, Korshin EE, Ruthstein S, Gruzman A.

Medchemcomm. 2018 Dec 13;10(2):280-293. doi: 10.1039/c8md00419f. eCollection 2019 Feb 1.

PMID:
30881615
5.

A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis-causing mutation.

Chen X, Zhu S, Zhenin M, Xu W, Bose SJ, Wong MP, Leung GPH, Senderowitz H, Chen JH.

FASEB J. 2019 Apr;33(4):5126-5142. doi: 10.1096/fj.201801218RR. Epub 2019 Jan 22.

PMID:
30668920
6.

Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-( n-octylamino)pyrimidin-2(1 H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model.

Trifonov L, Nudelman V, Zhenin M, Matsree E, Afri M, Schmerling B, Cohen G, Jozwiak K, Weitman M, Korshin E, Senderowitz H, Shainberg A, Hochhauser E, Gruzman A.

J Med Chem. 2018 Dec 27;61(24):11309-11326. doi: 10.1021/acs.jmedchem.8b01471. Epub 2018 Dec 11.

PMID:
30507195
7.

Visualization of Solar Cell Library Space by Dimensionality Reduction Methods.

Kaspi O, Yosipof A, Senderowitz H.

J Chem Inf Model. 2018 Dec 24;58(12):2428-2439. doi: 10.1021/acs.jcim.8b00552. Epub 2018 Dec 13.

PMID:
30485100
8.

Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy.

Atzmon A, Herrero M, Sharet-Eshed R, Gilad Y, Senderowitz H, Elroy-Stein O.

Front Mol Neurosci. 2018 Sep 18;11:336. doi: 10.3389/fnmol.2018.00336. eCollection 2018.

9.

Guaiacol as a drug candidate for treating adult polyglucosan body disease.

Kakhlon O, Ferreira I, Solmesky LJ, Khazanov N, Lossos A, Alvarez R, Yetil D, Pampou S, Weil M, Senderowitz H, Escriba P, Yue WW, Akman HO.

JCI Insight. 2018 Sep 6;3(17). pii: 99694. doi: 10.1172/jci.insight.99694. eCollection 2018 Sep 6.

10.

Rescoring of docking poses under Occam's Razor: are there simpler solutions?

Zhenin M, Bahia MS, Marcou G, Varnek A, Senderowitz H, Horvath D.

J Comput Aided Mol Des. 2018 Sep;32(9):877-888. doi: 10.1007/s10822-018-0155-5. Epub 2018 Sep 1.

PMID:
30173397
11.

PV Analyzer: A Decision Support System for Photovoltaic Solar Cells Libraries.

Kaspi O, Yosipof A, Senderowitz H.

Mol Inform. 2018 Sep;37(9-10):e1800067. doi: 10.1002/minf.201800067. Epub 2018 Jul 18.

PMID:
30022619
12.

Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.

Wang C, Aleksandrov AA, Yang Z, Forouhar F, Proctor EA, Kota P, An J, Kaplan A, Khazanov N, Boël G, Stockwell BR, Senderowitz H, Dokholyan NV, Riordan JR, Brouillette CG, Hunt JF.

J Biol Chem. 2018 Nov 16;293(46):17685-17704. doi: 10.1074/jbc.RA117.000819. Epub 2018 Jun 14.

PMID:
29903914
13.

The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing.

Ortuso F, Bagetta D, Maruca A, Talarico C, Bolognesi ML, Haider N, Borges F, Bryant S, Langer T, Senderowitz H, Alcaro S.

Front Chem. 2018 Apr 19;6:130. doi: 10.3389/fchem.2018.00130. eCollection 2018.

14.

Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-Pα,α-Dithiophosphate Analogues.

Zelikman V, Pelletier J, Simhaev L, Sela A, Gendron FP, Arguin G, Senderowitz H, Sévigny J, Fischer B.

J Med Chem. 2018 May 10;61(9):3939-3951. doi: 10.1021/acs.jmedchem.7b01906. Epub 2018 May 2.

PMID:
29681152
15.

Materials Informatics.

Senderowitz H, Tropsha A.

J Chem Inf Model. 2018 Jul 23;58(7):1313-1314. doi: 10.1021/acs.jcim.8b00016. Epub 2018 Apr 11. No abstract available.

PMID:
29638126
16.

Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1.

Yang Z, Hildebrandt E, Jiang F, Aleksandrov AA, Khazanov N, Zhou Q, An J, Mezzell AT, Xavier BM, Ding H, Riordan JR, Senderowitz H, Kappes JC, Brouillette CG, Urbatsch IL.

Biochim Biophys Acta Biomembr. 2018 May;1860(5):1193-1204. doi: 10.1016/j.bbamem.2018.02.006. Epub 2018 Feb 7.

17.

RANdom SAmple Consensus (RANSAC) algorithm for material-informatics: application to photovoltaic solar cells.

Kaspi O, Yosipof A, Senderowitz H.

J Cheminform. 2017 Jun 6;9(1):34. doi: 10.1186/s13321-017-0224-0.

18.

A novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease.

Solmesky LJ, Khazanov N, Senderowitz H, Wang P, Minassian BA, Ferreira IM, Yue WW, Lossos A, Weil M, Kakhlon O.

Biochem J. 2017 Sep 28;474(20):3403-3420. doi: 10.1042/BCJ20170469.

19.

Molecular Dynamics Flexible Fitting Simulations Identify New Models of the Closed State of the Cystic Fibrosis Transmembrane Conductance Regulator Protein.

Simhaev L, McCarty NA, Ford RC, Senderowitz H.

J Chem Inf Model. 2017 Aug 28;57(8):1932-1946. doi: 10.1021/acs.jcim.7b00091. Epub 2017 Jul 18.

PMID:
28657312
20.

Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy.

Munder A, Israel LL, Kahremany S, Ben-Shabat-Binyamini R, Zhang C, Kolitz-Domb M, Viskind O, Levine A, Senderowitz H, Chessler S, Lellouche JP, Gruzman A.

ACS Appl Mater Interfaces. 2017 Jan 18;9(2):1189-1206. doi: 10.1021/acsami.6b10568. Epub 2017 Jan 3.

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