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Items: 1 to 20 of 23


Pharmacological Profile of the Bradycardic Agent Ivabradine on Human Cardiac Ion Channels.

Haechl N, Ebner J, Hilber K, Todt H, Koenig X.

Cell Physiol Biochem. 2019;53(1):36-48. doi: 10.33594/000000119.


Calcium current properties in dystrophin-deficient ventricular cardiomyocytes from aged mdx mice.

Rubi L, Todt H, Kubista H, Koenig X, Hilber K.

Physiol Rep. 2018 Jan;6(1). doi: 10.14814/phy2.13567.


Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures.

Cervenka R, Lukacs P, Gawali VS, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Sandtner W, Stary-Weinzinger A, Todt H.

Sci Rep. 2018 Jan 12;8(1):631. doi: 10.1038/s41598-017-18919-1.


C2-Modified Sparteine Derivatives Are a New Class of Potentially Long-Acting Sodium Channel Blockers.

Gawali VS, Simeonov S, Drescher M, Knott T, Scheel O, Kudolo J, Kählig H, Hochenegg U, Roller A, Todt H, Maulide N.

ChemMedChem. 2017 Nov 22;12(22):1819-1822. doi: 10.1002/cmdc.201700568. Epub 2017 Nov 6.


Modulation of the heart's electrical properties by the anticonvulsant drug retigabine.

Rubi L, Kovar M, Zebedin-Brandl E, Koenig X, Dominguez-Rodriguez M, Todt H, Kubista H, Boehm S, Hilber K.

Toxicol Appl Pharmacol. 2017 Aug 15;329:309-317. doi: 10.1016/j.taap.2017.06.018. Epub 2017 Jun 20.


Decreased inward rectifier potassium current IK1 in dystrophin-deficient ventricular cardiomyocytes.

Rubi L, Koenig X, Kubista H, Todt H, Hilber K.

Channels (Austin). 2017 Mar 4;11(2):101-108. doi: 10.1080/19336950.2016.1228498. Epub 2016 Aug 25.


Mechanism of Modification, by Lidocaine, of Fast and Slow Recovery from Inactivation of Voltage-Gated Na⁺ Channels.

Gawali VS, Lukacs P, Cervenka R, Koenig X, Rubi L, Hilber K, Sandtner W, Todt H.

Mol Pharmacol. 2015 Nov;88(5):866-79. doi: 10.1124/mol.115.099580. Epub 2015 Sep 10.


Proper Voltage-Dependent Ion Channel Function in Dysferlin-Deficient Cardiomyocytes.

Rubi L, Gawali VS, Kubista H, Todt H, Hilber K, Koenig X.

Cell Physiol Biochem. 2015;36(3):1049-58. doi: 10.1159/000430278. Epub 2015 Jun 18.


Late cardiac sodium current can be assessed using automated patch-clamp.

Chevalier M, Amuzescu B, Gawali V, Todt H, Knott T, Scheel O, Abriel H.

F1000Res. 2014 Oct 16;3:245. doi: 10.12688/f1000research.5544.1. eCollection 2014.


Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.

Lukacs P, Gawali VS, Cervenka R, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Stary-Weinzinger A, Todt H.

J Biol Chem. 2014 Aug 1;289(31):21770-81. doi: 10.1074/jbc.M113.541763. Epub 2014 Jun 19.


Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart.

Koenig X, Rubi L, Obermair GJ, Cervenka R, Dang XB, Lukacs P, Kummer S, Bittner RE, Kubista H, Todt H, Hilber K.

Am J Physiol Heart Circ Physiol. 2014 Feb 15;306(4):H564-H573. doi: 10.1152/ajpheart.00441.2013. Epub 2013 Dec 13.


Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile.

Koenig X, Kovar M, Rubi L, Mike AK, Lukacs P, Gawali VS, Todt H, Hilber K, Sandtner W.

Toxicol Appl Pharmacol. 2013 Dec 1;273(2):259-68. doi: 10.1016/j.taap.2013.05.012. Epub 2013 May 22.


Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.

Koenig X, Dysek S, Kimbacher S, Mike AK, Cervenka R, Lukacs P, Nagl K, Dang XB, Todt H, Bittner RE, Hilber K.

PLoS One. 2011;6(5):e20300. doi: 10.1371/journal.pone.0020300. Epub 2011 May 23.


A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.

Zarrabi T, Cervenka R, Sandtner W, Lukacs P, Koenig X, Hilber K, Mille M, Lipkind GM, Fozzard HA, Todt H.

J Biol Chem. 2010 Dec 10;285(50):39458-70. doi: 10.1074/jbc.M110.132886. Epub 2010 Oct 6.


The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.

Cervenka R, Zarrabi T, Lukacs P, Todt H.

Mar Drugs. 2010 Apr 21;8(4):1373-93. doi: 10.3390/md8041373. Review.


Effects of duramycin on cardiac voltage-gated ion channels.

Zebedin E, Koenig X, Radenkovic M, Pankevych H, Todt H, Freissmuth M, Hilber K.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Mar;377(1):87-100. doi: 10.1007/s00210-007-0248-5. Epub 2008 Jan 5.


Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?

Szendroedi J, Sandtner W, Zarrabi T, Zebedin E, Hilber K, Dudley SC Jr, Fozzard HA, Todt H.

Biophys J. 2007 Dec 15;93(12):4209-24. Epub 2007 Aug 24.


C2C12 skeletal muscle cells adopt cardiac-like sodium current properties in a cardiac cell environment.

Zebedin E, Mille M, Speiser M, Zarrabi T, Sandtner W, Latzenhofer B, Todt H, Hilber K.

Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H439-50. Epub 2006 Sep 15.


Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channels.

Hilber K, Sandtner W, Zarrabi T, Zebedin E, Kudlacek O, Fozzard HA, Todt H.

Biochemistry. 2005 Oct 25;44(42):13874-82.


Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.

Sandtner W, Szendroedi J, Zarrabi T, Zebedin E, Hilber K, Glaaser I, Fozzard HA, Dudley SC, Todt H.

Mol Pharmacol. 2004 Sep;66(3):648-57.


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