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Reply to Krahn and Sebastiani.

Yki-Järvinen H, Lallukka-Brück S, Sutinen J.

Clin Infect Dis. 2019 Sep 20. pii: ciz930. doi: 10.1093/cid/ciz930. [Epub ahead of print] No abstract available.


Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids.

Luukkonen PK, Nick A, Hölttä-Vuori M, Thiele C, Isokuortti E, Lallukka-Brück S, Zhou Y, Hakkarainen A, Lundbom N, Peltonen M, Orho-Melander M, Orešič M, Hyötyläinen T, Hodson L, Ikonen E, Yki-Järvinen H.

JCI Insight. 2019 Aug 22;4(16). pii: 127902. doi: 10.1172/jci.insight.127902.


Effects of Weighted Hula-Hooping Compared to Walking on Abdominal Fat, Trunk Muscularity, and Metabolic Parameters in Overweight Subjects: A Randomized Controlled Study.

Lahelma M, Sädevirta S, Lallukka-Brück S, Sevastianova K, Mustelin L, Gylling H, Rockette-Wagner B, Kriska AM, Yki-Järvinen H.

Obes Facts. 2019;12(4):385-396. doi: 10.1159/000500572. Epub 2019 Jun 19.


Natural course of NAFLD and type 2 diabetes in HIV-positive subjects with and without combination antiretroviral therapy (cART)-associated lipodystrophy: a 16-year follow-up study.

Lallukka-Brück S, Isokuortti E, Luukkonen PK, Hakkarainen A, Lundbom N, Sutinen J, Yki-Järvinen H.

Clin Infect Dis. 2019 May 25. pii: ciz435. doi: 10.1093/cid/ciz435. [Epub ahead of print]


Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers.

Buzkova J, Nikkanen J, Ahola S, Hakonen AH, Sevastianova K, Hovinen T, Yki-Järvinen H, Pietiläinen KH, Lönnqvist T, Velagapudi V, Carroll CJ, Suomalainen A.

EMBO Mol Med. 2018 Dec;10(12). pii: e9091. doi: 10.15252/emmm.201809091.


Diabetes, Liver Cancer, and Cirrhosis: What Next?

Yki-Järvinen H, Luukkonen PK.

Hepatology. 2018 Oct;68(4):1220-1222. doi: 10.1002/hep.30136. No abstract available.


Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars.

Luukkonen PK, Sädevirta S, Zhou Y, Kayser B, Ali A, Ahonen L, Lallukka S, Pelloux V, Gaggini M, Jian C, Hakkarainen A, Lundbom N, Gylling H, Salonen A, Orešič M, Hyötyläinen T, Orho-Melander M, Rissanen A, Gastaldelli A, Clément K, Hodson L, Yki-Järvinen H.

Diabetes Care. 2018 Aug;41(8):1732-1739. doi: 10.2337/dc18-0071. Epub 2018 May 29.


Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) - an 11-Year Prospective Study.

Lallukka S, Sädevirta S, Kallio MT, Luukkonen PK, Zhou Y, Hakkarainen A, Lundbom N, Orho-Melander M, Yki-Järvinen H.

Sci Rep. 2017 Nov 6;7(1):14561. doi: 10.1038/s41598-017-14706-0.


Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects.

Hua B, Hakkarainen A, Zhou Y, Lundbom N, Yki-Järvinen H.

Dig Liver Dis. 2018 Feb;50(2):168-174. doi: 10.1016/j.dld.2017.08.030. Epub 2017 Aug 23.


Serum Insulin Bioassay Reflects Insulin Sensitivity and Requirements in Type 1 Diabetes.

Janssen JAMJL, Llauradó G, Varewijck AJ, Groop PH, Forsblom C, Fernández-Veledo S, van den Dungen ESR, Vendrell J, Hofland LJ, Yki-Järvinen H.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3814-3821. doi: 10.1210/jc.2017-00892.


Better glycaemic control and less hypoglycaemia with insulin glargine 300 U/mL vs glargine 100 U/mL: 1-year patient-level meta-analysis of the EDITION clinical studies in people with type 2 diabetes.

Ritzel R, Roussel R, Giaccari A, Vora J, Brulle-Wohlhueter C, Yki-Järvinen H.

Diabetes Obes Metab. 2018 Mar;20(3):541-548. doi: 10.1111/dom.13105. Epub 2017 Oct 5. Review.


Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study.

Isokuortti E, Zhou Y, Peltonen M, Bugianesi E, Clement K, Bonnefont-Rousselot D, Lacorte JM, Gastaldelli A, Schuppan D, Schattenberg JM, Hakkarainen A, Lundbom N, Jousilahti P, Männistö S, Keinänen-Kiukaanniemi S, Saltevo J, Anstee QM, Yki-Järvinen H.

Diabetologia. 2017 Oct;60(10):1873-1882. doi: 10.1007/s00125-017-4340-1. Epub 2017 Jun 29.


Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD.

Luukkonen PK, Zhou Y, Nidhina Haridas PA, Dwivedi OP, Hyötyläinen T, Ali A, Juuti A, Leivonen M, Tukiainen T, Ahonen L, Scott E, Palmer JM, Arola J, Orho-Melander M, Vikman P, Anstee QM, Olkkonen VM, Orešič M, Groop L, Yki-Järvinen H.

J Hepatol. 2017 Jul;67(1):128-136. doi: 10.1016/j.jhep.2017.02.014. Epub 2017 Feb 22.


Out of the frying pan: dietary saturated fat influences nonalcoholic fatty liver disease.

Parks E, Yki-Järvinen H, Hawkins M.

J Clin Invest. 2017 Feb 1;127(2):454-456. doi: 10.1172/JCI92407. Epub 2017 Jan 23.


Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans.

Lallukka S, Luukkonen PK, Zhou Y, Isokuortti E, Leivonen M, Juuti A, Hakkarainen A, Orho-Melander M, Lundbom N, Olkkonen VM, Lassila R, Yki-Järvinen H.

Thromb Haemost. 2017 Jan 26;117(2):286-294. doi: 10.1160/TH16-09-0716. Epub 2016 Dec 8.


Influence of Ethnicity on the Accuracy of Non-Invasive Scores Predicting Non-Alcoholic Fatty Liver Disease.

Xia MF, Yki-Järvinen H, Bian H, Lin HD, Yan HM, Chang XX, Zhou Y, Gao X.

PLoS One. 2016 Aug 31;11(8):e0160526. doi: 10.1371/journal.pone.0160526. eCollection 2016.


The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans.

Luukkonen PK, Zhou Y, Hyötyläinen T, Leivonen M, Arola J, Orho-Melander M, Orešič M, Yki-Järvinen H.

J Hepatol. 2016 Dec;65(6):1263-1265. doi: 10.1016/j.jhep.2016.07.045. Epub 2016 Aug 9. No abstract available.


Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites.

Zhou Y, Orešič M, Leivonen M, Gopalacharyulu P, Hyysalo J, Arola J, Verrijken A, Francque S, Van Gaal L, Hyötyläinen T, Yki-Järvinen H.

Clin Gastroenterol Hepatol. 2016 Oct;14(10):1463-1472.e6. doi: 10.1016/j.cgh.2016.05.046. Epub 2016 Jun 16.


Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD-A Systematic Review.

Petäjä EM, Yki-Järvinen H.

Int J Mol Sci. 2016 Apr 27;17(5). pii: E633. doi: 10.3390/ijms17050633. Review.


Diagnosis of non-alcoholic fatty liver disease (NAFLD).

Yki-Järvinen H.

Diabetologia. 2016 Jun;59(6):1104-11. doi: 10.1007/s00125-016-3944-1. Epub 2016 Apr 18. Review.


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