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Nutrients. 2020 Feb 13;12(2). pii: E467. doi: 10.3390/nu12020467.

Intestinal TG3- and TG2-Specific Plasma Cell Responses in Dermatitis Herpetiformis Patients Undergoing a Gluten Challenge.

Author information

1
Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.
2
Tampere Center for Child Health Research, Tampere University, Tampere, the Department of Paediatrics, Tampere University Hospital, 33520 Tampere, Finland.
3
The University Consortium of Seinäjoki and Seinäjoki Central Hospital, 60220 Seinäjoki, Finland.
4
Department of Internal Medicine, Tampere University Hospital, 33520 Tampere, Finland.
5
Department of Dermatology, Tampere University Hospital, 33520 Tampere, Finland.
6
Faculty of Social Sciences, Tampere University, 33520 Tampere, Finland.

Abstract

Dermatitis herpetiformis (DH), a cutaneous manifestation of coeliac disease, is characterized by transglutaminase (TG) 3-targeted dermal immunoglobulin A (IgA) deposits. The treatment for DH is the same as for coeliac disease, namely a life-long gluten-free diet. DH patients typically have gluten-dependent circulating autoantibodies targeting TG3 and TG2, and plasma cells secreting such autoantibodies have been detected in the small intestinal mucosa. This study investigates the gluten-responsiveness of intestinal TG3 and TG2 antibody-secreting plasma cells in 16 treated DH patients undergoing a gluten challenge. The frequency of both plasma cell populations increased significantly during the challenge, and their frequency correlated with the corresponding serum autoantibody levels at post-challenge. TG3-specific plasma cells were absent in all 18 untreated coeliac disease patients and seven non-coeliac control subjects on gluten-containing diets. These findings indicate that, in DH, both intestinal TG3- and TG2-antibody secreting plasma cells are gluten-dependent, and that TG3-antibody secreting plasma cells are DH-specific.

KEYWORDS:

autoantibody; coeliac disease; dermatitis herpetiformis; plasma cell; transglutaminase

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