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Proteomes. 2017 Aug 7;5(3). pii: E21. doi: 10.3390/proteomes5030021.

Role of Salivary Biomarkers in Detection of Cardiovascular Diseases (CVD).

Author information

1
Department of Orthodontics, College of Dentistry, Karachi Medical and Dental College, Karachi 74700, Pakistan. saadmemon_786@hotmail.com.
2
Department of Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia. drzohaibkhurshid@gmail.com.
3
Department of Restorative Dentistry, Dar Al Uloom University, Riyadh 13314, Saudia Arabia. fayez.h@dau.edu.sa.
4
Department of Preventive Dental Sciences, Dar Al Uloom University, Riyadh 13314, Saudia Arabia. m.naseem@dau.edu.sa.
5
Department of Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia. hwadani@hotmail.com.
6
Department of Oral Medicine, Islamabad Dental Hospital (IDH), Islamabad 44000, Pakistan. Haafsa.OralMed16@iideas.edu.pk.
7
Department of Oral Pathology, College of Dentistry, Baqai University, Karachi 74600, Pakistan. rabia.sannam.khan@gmail.com.

Abstract

Human whole mouth saliva (WMS) is secreted by salivary glands, namely parotid, submandibular/sublingual and other minor glands of the oral cavity. It is secreted in a systematic way, and contain informative proteins and peptides for the early detection of contagious diseases and organ-related diseases. The role of WMS as a liquid biopsy for the detection of cardiovascular diseases (CVD) through Myoglobin (MYO), Cardiac troponin I (cTnI), Creatine phosphokinase MB (CK-MB), Myeloperoxidase (MPO), brain natriuretic peptide (NT-proBNP), Exosomal miRNA, C-Reactive Protein (CRP), Matrix metalloproteinase-8 (MMP-8), MMP-9 and tissue inhibitor of MMP-8 (TIMP-1), leukotriene B4 has been well reported in last decade, that have been reviewed in the literature comprehensively below.

KEYWORDS:

biomarkers; cardiovascular diseases and diagnosis; proteins; saliva

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