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Items: 13


In vitro assessment of clevidipine using the profilin1 hypertensive mouse model.

Hassanain HH, Hassona MD, Puente EG, Sun C, Abouelnaga ZA, Tulman DB, Bergese SD.

Pharmaceuticals (Basel). 2013 Apr 29;6(5):623-33. doi: 10.3390/ph6050623.


Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase.

Elnakish MT, Hassanain HH, Janssen PM, Angelos MG, Khan M.

J Pathol. 2013 Nov;231(3):290-300. doi: 10.1002/path.4255. Review.


Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles.

Elnakish MT, Moldovan L, Khan M, Hassanain HH, Janssen PM.

J Cardiovasc Pharmacol. 2013 Jun;61(6):536-44. doi: 10.1097/FJC.0b013e31828d4b9d.


Cardiomyocyte-specific overexpression of an active form of Rac predisposes the heart to increased myocardial stunning and ischemia-reperfusion injury.

Talukder MA, Elnakish MT, Yang F, Nishijima Y, Alhaj MA, Velayutham M, Hassanain HH, Zweier JL.

Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H294-302. doi: 10.1152/ajpheart.00367.2012. Epub 2012 Nov 16.


Vascular remodeling-associated hypertension leads to left ventricular hypertrophy and contractile dysfunction in profilin-1 transgenic mice.

Elnakish MT, Hassanain HH, Janssen PM.

J Cardiovasc Pharmacol. 2012 Dec;60(6):544-52. doi: 10.1097/FJC.0b013e318271225d.


Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis.

Elnakish MT, Hassona MD, Alhaj MA, Moldovan L, Janssen PM, Khan M, Hassanain HH.

PLoS One. 2012;7(8):e42500. doi: 10.1371/journal.pone.0042500. Epub 2012 Aug 24.


Impact of disrupting adenosine A₃ receptors (A₃⁻/⁻ AR) on colonic motility or progression of colitis in the mouse.

Ren T, Grants I, Alhaj M, McKiernan M, Jacobson M, Hassanain HH, Frankel W, Wunderlich J, Christofi FL.

Inflamm Bowel Dis. 2011 Aug;17(8):1698-713. doi: 10.1002/ibd.21553. Epub 2010 Dec 3.


Cardiac remodeling caused by transgenic overexpression of a corn Rac gene.

Elnakish MT, Awad MM, Hassona MD, Alhaj MA, Kulkarni A, Citro LA, Sayyid M, Abouelnaga ZA, El-Sayed O, Kuppusamy P, Moldovan L, Khan M, Hassanain HH.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H868-80. doi: 10.1152/ajpheart.00807.2010. Epub 2011 May 27.


Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.

Bozarov A, Wang YZ, Yu JG, Wunderlich J, Hassanain HH, Alhaj M, Cooke HJ, Grants I, Ren T, Christofi FL.

Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1147-62. doi: 10.1152/ajpgi.00295.2009. Epub 2009 Oct 1.


Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation.

Chen Z, Suntres Z, Palmer J, Guzman J, Javed A, Xue J, Yu JG, Cooke H, Awad H, Hassanain HH, Cardounel AJ, Christofi FL.

Int J Parasitol. 2007 Jun;37(7):743-61. Epub 2007 Jan 14.


Hypertension caused by transgenic overexpression of Rac1.

Hassanain HH, Gregg D, Marcelo ML, Zweier JL, Souza HP, Selvakumar B, Ma Q, Moustafa-Bayoumi M, Binkley PF, Flavahan NA, Morris M, Dong C, Goldschmidt-Clermont PJ.

Antioxid Redox Signal. 2007 Jan;9(1):91-100.


ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis.

Guzman J, Yu JG, Suntres Z, Bozarov A, Cooke H, Javed N, Auer H, Palatini J, Hassanain HH, Cardounel AJ, Javed A, Grants I, Wunderlich JE, Christofi FL.

Inflamm Bowel Dis. 2006 Aug;12(8):766-89.


Smooth muscle cell expression of a constitutive active form of human Rac 1 accelerates cutaneous wound repair.

Hassanain HH, Irshaid F, Wisel S, Sheridan J, Michler RE, Goldschmidt-Clermont PJ.

Surgery. 2005 Jan;137(1):92-101.


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