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Items: 1 to 20 of 40


Telomeres and Longevity: A Cause or an Effect?

Adwan Shekhidem H, Sharvit L, Leman E, Manov I, Roichman A, Holtze S, M Huffman D, Y Cohen H, Bernd Hildebrandt T, Shams I, Atzmon G.

Int J Mol Sci. 2019 Jul 1;20(13). pii: E3233. doi: 10.3390/ijms20133233.


LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.

Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V.

Cell Metab. 2019 Apr 2;29(4):871-885.e5. doi: 10.1016/j.cmet.2019.02.014. Epub 2019 Mar 7.


Role for the longevity protein SIRT6 in primate development.

Naiman S, Cohen HY.

Nature. 2018 Aug;560(7720):559-560. doi: 10.1038/d41586-018-05970-9. No abstract available.


Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance.

Gertman O, Omer D, Hendler A, Stein D, Onn L, Khukhin Y, Portillo M, Zarivach R, Cohen HY, Toiber D, Aharoni A.

Sci Rep. 2018 Feb 23;8(1):3538. doi: 10.1038/s41598-018-21887-9.


Breaking the Ceiling of Human Maximal Life span.

Ben-Haim MS, Kanfi Y, Mitchell SJ, Maoz N, Vaughan KL, Amariglio N, Lerrer B, de Cabo R, Rechavi G, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1465-1471. doi: 10.1093/gerona/glx219.


Sirt6 alters adult hippocampal neurogenesis.

Okun E, Marton D, Cohen D, Griffioen K, Kanfi Y, Illouz T, Madar R, Cohen HY.

PLoS One. 2017 Jun 23;12(6):e0179681. doi: 10.1371/journal.pone.0179681. eCollection 2017.


New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure.

Amit U, Kain D, Wagner A, Sahu A, Nevo-Caspi Y, Gonen N, Molotski N, Konfino T, Landa N, Naftali-Shani N, Blum G, Merquiol E, Karo-Atar D, Kanfi Y, Paret G, Munitz A, Cohen HY, Ruppin E, Hannenhalli S, Leor J.

J Am Heart Assoc. 2017 May 20;6(5). pii: e005108. doi: 10.1161/JAHA.116.005108.


Characterization of physiological defects in adult SIRT6-/- mice.

Peshti V, Obolensky A, Nahum L, Kanfi Y, Rathaus M, Avraham M, Tinman S, Alt FW, Banin E, Cohen HY.

PLoS One. 2017 Apr 27;12(4):e0176371. doi: 10.1371/journal.pone.0176371. eCollection 2017.


Self-Assembled Cyclic d,l-α-Peptides as Generic Conformational Inhibitors of the α-Synuclein Aggregation and Toxicity: In Vitro and Mechanistic Studies.

Chemerovski-Glikman M, Rozentur-Shkop E, Richman M, Grupi A, Getler A, Cohen HY, Shaked H, Wallin C, Wärmländer SK, Haas E, Gräslund A, Chill JH, Rahimipour S.

Chemistry. 2016 Sep 26;22(40):14236-46. doi: 10.1002/chem.201601830. Epub 2016 Aug 19.


SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan.

Roichman A, Kanfi Y, Glazz R, Naiman S, Amit U, Landa N, Tinman S, Stein I, Pikarsky E, Leor J, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):603-615. doi: 10.1093/gerona/glw152.


Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis.

Elhanati S, Ben-Hamo R, Kanfi Y, Varvak A, Glazz R, Lerrer B, Efroni S, Cohen HY.

Cell Rep. 2016 Jan 12;14(2):234-42. doi: 10.1016/j.celrep.2015.12.023. Epub 2015 Dec 31.


The complex role of SIRT6 in carcinogenesis.

Lerrer B, Gertler AA, Cohen HY.

Carcinogenesis. 2016 Feb;37(2):108-18. doi: 10.1093/carcin/bgv167. Epub 2015 Dec 30. Review.


The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance.

Chuprin A, Avin A, Goldfarb Y, Herzig Y, Levi B, Jacob A, Sela A, Katz S, Grossman M, Guyon C, Rathaus M, Cohen HY, Sagi I, Giraud M, McBurney MW, Husebye ES, Abramson J.

Nat Immunol. 2015 Jul;16(7):737-45. doi: 10.1038/ni.3194. Epub 2015 May 25.


ModuleBlast: identifying activated sub-networks within and across species.

Zinman GE, Naiman S, O'Dee DM, Kumar N, Nau GJ, Cohen HY, Bar-Joseph Z.

Nucleic Acids Res. 2015 Feb 18;43(3):e20. doi: 10.1093/nar/gku1224. Epub 2014 Nov 26.


Sirtuin 6 protects the heart from hypoxic damage.

Maksin-Matveev A, Kanfi Y, Hochhauser E, Isak A, Cohen HY, Shainberg A.

Exp Cell Res. 2015 Jan 1;330(1):81-90. doi: 10.1016/j.yexcr.2014.07.013. Epub 2014 Jul 24.


The yeast forkhead HCM1 controls life span independent of calorie restriction.

Maoz N, Gabay O, Waldman Ben-Asher H, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):444-53. doi: 10.1093/gerona/glu059. Epub 2014 May 15.


Mammalian conserved ADAR targets comprise only a small fragment of the human editosome.

Pinto Y, Cohen HY, Levanon EY.

Genome Biol. 2014 Jan 7;15(1):R5. doi: 10.1186/gb-2014-15-1-r5.


SIRT6, a protein with many faces.

Gertler AA, Cohen HY.

Biogerontology. 2013 Dec;14(6):629-39. doi: 10.1007/s10522-013-9478-8. Epub 2013 Nov 10. Review.


Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.

Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M.

Nat Chem Biol. 2013 Nov;9(11):693-700. doi: 10.1038/nchembio.1352. Epub 2013 Sep 29.


Multiple regulatory layers of SREBP1/2 by SIRT6.

Elhanati S, Kanfi Y, Varvak A, Roichman A, Carmel-Gross I, Barth S, Gibor G, Cohen HY.

Cell Rep. 2013 Sep 12;4(5):905-12. doi: 10.1016/j.celrep.2013.08.006. Epub 2013 Sep 5.

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