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Items: 1 to 20 of 72

1.

TBC1D4 is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction.

Kjøbsted R, Chadt A, Jørgensen NO, Kido K, Larsen JK, de Wendt C, Al-Hasani H, Wojtaszewski JFP.

Diabetes. 2019 Jun 7. pii: db180769. doi: 10.2337/db18-0769. [Epub ahead of print]

PMID:
31175100
2.

AMPK and TBC1D1 Regulate Muscle Glucose Uptake After, but Not During, Exercise and Contraction.

Kjøbsted R, Roll JLW, Jørgensen NO, Birk JB, Foretz M, Viollet B, Chadt A, Al-Hasani H, Wojtaszewski JFP.

Diabetes. 2019 Jul;68(7):1427-1440. doi: 10.2337/db19-0050. Epub 2019 Apr 22.

PMID:
31010958
3.

Exosomal proteins constitute an essential part of the human adipose tissue secretome.

Hartwig S, De Filippo E, Göddeke S, Knebel B, Kotzka J, Al-Hasani H, Roden M, Lehr S, Sell H.

Biochim Biophys Acta Proteins Proteom. 2018 Nov 28. pii: S1570-9639(18)30207-3. doi: 10.1016/j.bbapap.2018.11.009. [Epub ahead of print]

PMID:
30502511
4.

A variant of the glucose transporter gene SLC2A2 modifies the glycaemic response to metformin therapy in recently diagnosed type 2 diabetes.

Rathmann W, Strassburger K, Bongaerts B, Kuss O, Müssig K, Burkart V, Szendroedi J, Kotzka J, Knebel B, Al-Hasani H, Roden M; GDS Group.

Diabetologia. 2019 Feb;62(2):286-291. doi: 10.1007/s00125-018-4759-z. Epub 2018 Nov 9.

PMID:
30413829
5.

Synthetic Cargo Internalization Receptor System for Nanoparticle Tracking of Individual Cell Populations by Fluorine Magnetic Resonance Imaging.

Temme S, Baran P, Bouvain P, Grapentin C, Krämer W, Knebel B, Al-Hasani H, Moll JM, Floss D, Schrader J, Schubert R, Flögel U, Scheller J.

ACS Nano. 2018 Nov 27;12(11):11178-11192. doi: 10.1021/acsnano.8b05698. Epub 2018 Nov 5.

PMID:
30372619
6.

Two Novel Candidate Genes for Insulin Secretion Identified by Comparative Genomics of Multiple Backcross Mouse Populations.

Schallschmidt T, Lebek S, Altenhofen D, Damen M, Schulte Y, Knebel B, Herwig R, Rasche A, Stermann T, Kamitz A, Hallahan N, Jähnert M, Vogel H, Schürmann A, Chadt A, Al-Hasani H.

Genetics. 2018 Dec;210(4):1527-1542. doi: 10.1534/genetics.118.301578. Epub 2018 Oct 19.

PMID:
30341086
7.

AKT and AMP-activated protein kinase regulate TBC1D1 through phosphorylation and its interaction with the cytosolic tail of insulin-regulated aminopeptidase IRAP.

Mafakheri S, Flörke RR, Kanngießer S, Hartwig S, Espelage L, De Wendt C, Schönberger T, Hamker N, Lehr S, Chadt A, Al-Hasani H.

J Biol Chem. 2018 Nov 16;293(46):17853-17862. doi: 10.1074/jbc.RA118.005040. Epub 2018 Oct 1.

PMID:
30275018
8.

Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation.

Weimershaus M, Mauvais FX, Saveanu L, Adiko C, Babdor J, Abramova A, Montealegre S, Lawand M, Evnouchidou I, Huber KJ, Chadt A, Zwick M, Vargas P, Dussiot M, Lennon-Dumenil AM, Brocker T, Al-Hasani H, van Endert P.

Cell Rep. 2018 Sep 25;24(13):3568-3581. doi: 10.1016/j.celrep.2018.08.041.

9.

Reduced expression of stearoyl-CoA desaturase-1, but not free fatty acid receptor 2 or 4 in subcutaneous adipose tissue of patients with newly diagnosed type 2 diabetes mellitus.

Bódis K, Kahl S, Simon MC, Zhou Z, Sell H, Knebel B, Tura A, Strassburger K, Burkart V, Müssig K, Markgraf D, Al-Hasani H, Szendroedi J, Roden M; GDS Study Group.

Nutr Diabetes. 2018 Sep 7;8(1):49. doi: 10.1038/s41387-018-0054-9.

10.

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity.

Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM.

Biochem J. 2018 Sep 25;475(18):2969-2983. doi: 10.1042/BCJ20180475.

11.

FGF21 regulates insulin sensitivity following long-term chronic stress.

Jelenik T, Dille M, Müller-Lühlhoff S, Kabra DG, Zhou Z, Binsch C, Hartwig S, Lehr S, Chadt A, Peters EMJ, Kruse J, Roden M, Al-Hasani H, Castañeda TR.

Mol Metab. 2018 Oct;16:126-138. doi: 10.1016/j.molmet.2018.06.012. Epub 2018 Jun 20.

12.

Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis.

Klatt C, Krüger I, Zey S, Krott KJ, Spelleken M, Gowert NS, Oberhuber A, Pfaff L, Lückstädt W, Jurk K, Schaller M, Al-Hasani H, Schrader J, Massberg S, Stark K, Schelzig H, Kelm M, Elvers M.

J Clin Invest. 2018 Aug 31;128(9):3906-3925. doi: 10.1172/JCI92077. Epub 2018 Aug 13.

13.

A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes.

Vogel H, Kamitz A, Hallahan N, Lebek S, Schallschmidt T, Jonas W, Jähnert M, Gottmann P, Zellner L, Kanzleiter T, Damen M, Altenhofen D, Burkhardt R, Renner S, Dahlhoff M, Wolf E, Müller TD, Blüher M, Joost HG, Chadt A, Al-Hasani H, Schürmann A.

Hum Mol Genet. 2018 Sep 1;27(17):3099-3112. doi: 10.1093/hmg/ddy217.

14.

Synthetic cytokine receptors transmit biological signals using artificial ligands.

Engelowski E, Schneider A, Franke M, Xu H, Clemen R, Lang A, Baran P, Binsch C, Knebel B, Al-Hasani H, Moll JM, Floß DM, Lang PA, Scheller J.

Nat Commun. 2018 May 23;9(1):2034. doi: 10.1038/s41467-018-04454-8.

15.

Regulation of RabGAPs involved in insulin action.

Mafakheri S, Chadt A, Al-Hasani H.

Biochem Soc Trans. 2018 Jun 19;46(3):683-690. doi: 10.1042/BST20170479. Epub 2018 May 21. Review.

PMID:
29784647
16.

Deletion of the RabGAP TBC1D1 Leads to Enhanced Insulin Secretion and Fatty Acid Oxidation in Islets From Male Mice.

Stermann T, Menzel F, Weidlich C, Jeruschke K, Weiss J, Altenhofen D, Benninghoff T, Pujol A, Bosch F, Rustenbeck I, Ouwens DM, Thoresen GH, de Wendt C, Lebek S, Schallschmidt T, Kragl M, Lammert E, Chadt A, Al-Hasani H.

Endocrinology. 2018 Apr 1;159(4):1748-1761. doi: 10.1210/en.2018-00087.

PMID:
29481597
17.

CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health.

Göddeke S, Knebel B, Fahlbusch P, Hörbelt T, Poschmann G, van de Velde F, Benninghoff T, Al-Hasani H, Jacob S, Van Nieuwenhove Y, Lapauw B, Lehr S, Ouwens DM, Kotzka J.

Int J Obes (Lond). 2018 Jun;42(5):1039-1050. doi: 10.1038/s41366-018-0022-4. Epub 2018 Feb 21.

PMID:
29467502
18.

Alteration of Liver Peroxisomal and Mitochondrial Functionality in the NZO Mouse Model of Metabolic Syndrome.

Knebel B, Göddeke S, Hartwig S, Hörbelt T, Fahlbusch P, Al-Hasani H, Jacob S, Koellmer C, Nitzgen U, Schiller M, Lehr S, Kotzka J.

Proteomics Clin Appl. 2018 Jan;12(1). doi: 10.1002/prca.201700028. Epub 2017 Dec 11.

PMID:
29068532
19.

Hypoxia in Combination With Muscle Contraction Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle via the HIF-1α Pathway.

Görgens SW, Benninghoff T, Eckardt K, Springer C, Chadt A, Melior A, Wefers J, Cramer A, Jensen J, Birkeland KI, Drevon CA, Al-Hasani H, Eckel J.

Diabetes. 2017 Nov;66(11):2800-2807. doi: 10.2337/db16-1488. Epub 2017 Aug 15.

20.

Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking.

Zhou Z, Menzel F, Benninghoff T, Chadt A, Du C, Holman GD, Al-Hasani H.

FEBS Lett. 2017 Jan;591(1):88-96. doi: 10.1002/1873-3468.12509. Epub 2016 Dec 20.

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