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Molecules. 2019 Mar 5;24(5). pii: E912. doi: 10.3390/molecules24050912.

Comparison among Activities and Isoflavonoids from Pueraria thunbergiana Aerial Parts and Root.

Author information

1
Herbal Medicine Research Division, Korea Institute of Oriental Medicine,1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea. ejson@kiom.re.kr.
2
Division of Bio-Technology and Convergence, Daegu Haany University, 285-10 Eobongji-gil, Gyeongsan, Gyeongsangbuk-do 38578, Korea. yjm2777@naver.com.
3
Division of Bio-Technology and Convergence, Daegu Haany University, 285-10 Eobongji-gil, Gyeongsan, Gyeongsangbuk-do 38578, Korea. anbj@dhu.ac.kr.
4
Herbal Medicine Research Division, Korea Institute of Oriental Medicine,1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea. candykong@kiom.re.kr.
5
Department of Microbiology, Faculty of Natural Science, Dankook University, Cheonan, Chungnam 31116, Korea. jimincha@dankook.ac.kr.
6
Division of Bio-Technology and Convergence, Daegu Haany University, 285-10 Eobongji-gil, Gyeongsan, Gyeongsangbuk-do 38578, Korea. chigy@dhu.ac.kr.
7
Herbal Medicine Research Division, Korea Institute of Oriental Medicine,1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea. dskim@kiom.re.kr.

Abstract

: Kudzu (Pueraria thunbergiana Benth.) has long been used as a food and medicine for many centuries. The root is the most commonly used portion of the plant, but the aerial parts are occasionally used as well. In this study, we investigated the constituent compounds and biological activities of the aerial parts, leaves, stems, and sprouts, and compared their constituents and activities with those of roots. Leaf extract showed a significantly higher TPC level at 59 ± 1.6 mg/g and lower free radical scavenging (FRS) values under 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), and NO inhibition at 437 ± 11, 121 ± 6.6 μg/mL and 107 ± 4.9 μg/mL, respectively, than those of sprout, stem, and root extract. Leaf extract also significantly suppressed lipopolysaccharide (LPS)-mediated gene expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). The main components of leaf extract were found to be genistin and daidzin. This study suggests that the leaves of kudzu are a good source of biological activities and isoflavones that can be used in functional or medicinal foods and cosmetics for the prevention or treatment of diseases related to inflammation and oxidative stress.

KEYWORDS:

COX-2; Kudzu leaves; NO; Phenolic content; Pueraria thunbergiana; iNOS

PMID:
30841642
PMCID:
PMC6429325
DOI:
10.3390/molecules24050912
[Indexed for MEDLINE]
Free PMC Article

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