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Items: 1 to 20 of 56

2.

ERE-dependent transcription and cell proliferation: Independency of these two processes mediated by the introduction of a sulfone function into the weak estrogen estrothiazine.

Jacquot Y, Spaggiari D, Schappler J, Lesniewska E, Rudaz S, Leclercq G.

Eur J Pharm Sci. 2017 Nov 15;109:169-181. doi: 10.1016/j.ejps.2017.07.026. Epub 2017 Jul 25.

PMID:
28754571
3.

ERα dimerization: a key factor for the weak estrogenic activity of an ERα modulator unable to compete with estradiol in binding assays.

Leclercq G, Laïos I, Elie-Caille C, Leiber D, Laurent G, Lesniewska E, Tanfin Z, Jacquot Y.

J Recept Signal Transduct Res. 2017 Apr;37(2):149-166. doi: 10.1080/10799893.2016.1203940. Epub 2016 Jul 12.

PMID:
27400858
4.

The sequence Pro295-Thr311 of the hinge region of oestrogen receptor α is involved in ERK1/2 activation via GPR30 in leiomyoma cells.

Leiber D, Burlina F, Byrne C, Robin P, Piesse C, Gonzalez L, Leclercq G, Tanfin Z, Jacquot Y.

Biochem J. 2015 Nov 15;472(1):97-109. doi: 10.1042/BJ20150744. Epub 2015 Sep 14.

PMID:
26371374
5.

Whole transcriptome analysis of the ERα synthetic fragment P295-T311 (ERα17p) identifies specific ERα-isoform (ERα, ERα36)-dependent and -independent actions in breast cancer cells.

Notas G, Kampa M, Pelekanou V, Troullinaki M, Jacquot Y, Leclercq G, Castanas E.

Mol Oncol. 2013 Jun;7(3):595-610. doi: 10.1016/j.molonc.2013.02.012. Epub 2013 Feb 20.

6.

Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer-considerations concerning related efficacy and safety.

Leclercq G, Jacquot Y.

J Steroid Biochem Mol Biol. 2014 Jan;139:237-44. doi: 10.1016/j.jsbmb.2012.12.010. Epub 2012 Dec 27. Review.

PMID:
23274118
7.

Electronic effects of 11β substituted 17β-estradiol derivatives and instrumental effects on the relative gas phase acidity.

Bourgoin-Voillard S, Fournier F, Afonso C, Zins EL, Jacquot Y, Pèpe C, Leclercq G, Tabet JC.

J Am Soc Mass Spectrom. 2012 Dec;23(12):2167-77. doi: 10.1007/s13361-012-0486-8. Epub 2012 Oct 2.

PMID:
23055074
8.

Palmitoylation regulates 17β-estradiol-induced estrogen receptor-α degradation and transcriptional activity.

La Rosa P, Pesiri V, Leclercq G, Marino M, Acconcia F.

Mol Endocrinol. 2012 May;26(5):762-74. doi: 10.1210/me.2011-1208. Epub 2012 Mar 22.

9.

ERα17p, a peptide reproducing the hinge region of the estrogen receptor α associates to biological membranes: A biophysical approach.

Byrne C, Khemtémourian L, Pelekanou V, Kampa M, Leclercq G, Sagan S, Castanas E, Burlina F, Jacquot Y.

Steroids. 2012 Aug;77(10):979-87. doi: 10.1016/j.steroids.2012.02.022. Epub 2012 Mar 8.

PMID:
22426414
10.

Biophysical studies of the interaction between calmodulin and the R²⁸⁷-T³¹¹ region of human estrogen receptor α reveals an atypical binding process.

Carlier L, Byrne C, Miclet E, Bourgoin-Voillard S, Nicaise M, Tabet JC, Desmadril M, Leclercq G, Lequin O, Jacquot Y.

Biochem Biophys Res Commun. 2012 Mar 9;419(2):356-61. doi: 10.1016/j.bbrc.2012.02.028. Epub 2012 Feb 10.

PMID:
22342729
11.

Calcium-induced activation of estrogen receptor alpha--New insight.

Leclercq G.

Steroids. 2012 Aug;77(10):924-7. doi: 10.1016/j.steroids.2012.01.012. Epub 2012 Jan 28. Review.

PMID:
22306577
12.

ERα36, a new variant of the ERα is expressed in triple negative breast carcinomas and has a specific transcriptomic signature in breast cancer cell lines.

Pelekanou V, Notas G, Kampa M, Tsentelierou E, Radojicic J, Leclercq G, Castanas E, Stathopoulos EN.

Steroids. 2012 Aug;77(10):928-34. doi: 10.1016/j.steroids.2011.12.016. Epub 2011 Dec 16.

PMID:
22198466
13.

Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis.

Pelekanou V, Leclercq G.

Int J Dev Biol. 2011;55(7-9):869-78. doi: 10.1387/ijdb.113369vp. Review.

14.

ERα17p, an ERα P295 -T311 fragment, modifies the migration of breast cancer cells, through actin cytoskeleton rearrangements.

Kampa M, Pelekanou V, Gallo D, Notas G, Troullinaki M, Pediaditakis I, Charalampopoulos I, Jacquot Y, Leclercq G, Castanas E.

J Cell Biochem. 2011 Dec;112(12):3786-96. doi: 10.1002/jcb.23309.

PMID:
21826705
15.

A critical view of the effects of phytoestrogens on hot flashes and breast cancer risk.

This P, de Cremoux P, Leclercq G, Jacquot Y.

Maturitas. 2011 Nov;70(3):222-6. doi: 10.1016/j.maturitas.2011.07.001. Epub 2011 Aug 2. Review.

PMID:
21813250
16.

Peptides targeting estrogen receptor alpha-potential applications for breast cancer treatment.

Leclercq G, Gallo D, Cossy J, Laïos I, Larsimont D, Laurent G, Jacquot Y.

Curr Pharm Des. 2011;17(25):2632-53. Review.

PMID:
21728983
17.

The estrogen receptor alpha-derived peptide ERα17p (P(295)-T(311)) exerts pro-apoptotic actions in breast cancer cells in vitro and in vivo, independently from their ERα status.

Pelekanou V, Kampa M, Gallo D, Notas G, Troullinaki M, Duvillier H, Jacquot Y, Stathopoulos EN, Castanas E, Leclercq G.

Mol Oncol. 2011 Feb;5(1):36-47. doi: 10.1016/j.molonc.2010.11.001. Epub 2010 Nov 27.

18.

Lack of sufficient information on the specificity and selectivity of commercial phytoestrogens preparations for therapeutic purposes.

Leclercq G, de Cremoux P, This P, Jacquot Y.

Maturitas. 2011 Jan;68(1):56-64. doi: 10.1016/j.maturitas.2010.10.003. Epub 2010 Nov 12. Review.

PMID:
21074339
19.

A ferrocenyl derivative of hydroxytamoxifen elicits an estrogen receptor-independent mechanism of action in breast cancer cell lines.

Vessières A, Corbet C, Heldt JM, Lories N, Jouy N, Laïos I, Leclercq G, Jaouen G, Toillon RA.

J Inorg Biochem. 2010 May;104(5):503-11. doi: 10.1016/j.jinorgbio.2009.12.020. Epub 2010 Jan 7.

PMID:
20116857
20.

Controversies concerning the use of phytoestrogens in menopause management: bioavailability and metabolism.

de Cremoux P, This P, Leclercq G, Jacquot Y.

Maturitas. 2010 Apr;65(4):334-9. doi: 10.1016/j.maturitas.2009.12.019. Epub 2010 Jan 18. Review.

PMID:
20080366

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