Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 7

1.

Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.

Guimarães DSM, de Sousa Luz LS, do Nascimento SB, Silva LR, de Miranda Martins NR, de Almeida HG, de Souza Reis V, Maluf SEC, Budu A, Marinho JA, Abramo C, Carmona AK, da Silva MG, da Silva GR, Kemmer VM, Butera AP, Ribeiro-Viana RM, Gazarini ML, Júnior CSN, Guimarães L, Dos Santos FV, de Castro WV, Viana GHR, de Brito CFA, de Pilla Varotti F.

Eur J Pharm Sci. 2019 Oct 1;138:105015. doi: 10.1016/j.ejps.2019.105015. Epub 2019 Jul 22.

PMID:
31344442
2.

Target-Guided Synthesis and Antiplasmodial Evaluation of a New Fluorinated 3-Alkylpyridine Marine Alkaloid Analog.

Barbosa CS, Guimarães DSM, Gonçalves AMMN, Barbosa MCDS, Alves E Costa ML, Nascimento Júnior CS, Guimarães L, Ribeiro-Viana RM, Dos Santos FV, Alves de Brito CF, de Pilla Varotti F, Ribeiro Viana GH.

ACS Omega. 2017 Nov 30;2(11):8264-8272. doi: 10.1021/acsomega.7b01302. Epub 2017 Nov 21.

3.

Synthesis and evaluation of the mutagenicity of 3-alkylpyridine marine alkaloid analogues with anticancer potential.

Barbosa MCS, de Souza Barbosa C, de Oliveira JT, Moreira NCS, de Miranda Martins NR, Alves Gomes GK, Caldeira CA, Alves E Costa ML, Martins Guimarães DS, Guimarães L, Nascimento CS Jr, de Pilla Varotti F, Ribeiro Viana GH, Santos FVD.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Jan;825:31-39. doi: 10.1016/j.mrgentox.2017.11.006. Epub 2017 Nov 24.

PMID:
29307373
4.

New 3-alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44+/high /CD24-/low subset of triple-negative breast cancer cell line.

de Lima AB, Barbosa CS, Gonçalves AMMN, Santos FVD, Viana GHR, Varotti FP, Silva LM.

Chem Biol Drug Des. 2017 Jul;90(1):5-11. doi: 10.1111/cbdd.12923. Epub 2017 Feb 7.

PMID:
27995747
5.

New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.

Soares RR, da Silva JM, Carlos BC, da Fonseca CC, de Souza LS, Lopes FV, de Paula Dias RM, Moreira PO, Abramo C, Viana GH, de Pila Varotti F, da Silva AD, Scopel KK.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2308-13. doi: 10.1016/j.bmcl.2015.04.014. Epub 2015 Apr 11.

PMID:
25920564
6.

Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity.

Gonçalves AM, de Lima AB, da Silva Barbosa MC, de Camargos LF, de Oliveira JT, de Souza Barbosa C, Villar JA, Costa AC, Silva IV, Silva LM, de Pilla Varotti F, dos Santos FV, Viana GH.

Mar Drugs. 2014 Jul 31;12(8):4361-78. doi: 10.3390/md12084361.

7.

Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate.

de Oliveira ME, Cenzi G, Nunes RR, Andrighetti CR, de Sousa Valadão DM, Dos Reis C, Simões CM, Nunes RJ, Júnior MC, Taranto AG, Sanchez BA, Viana GH, de Pilla Varotti F.

Molecules. 2013 Dec 10;18(12):15276-87. doi: 10.3390/molecules181215276.

Supplemental Content

Loading ...
Support Center