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Items: 1 to 20 of 32


Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.

Li Y, Li J, Wang R, Zhang L, Fu G, Wang X, Wang Y, Fang C, Zhang D, Du D, Ma X, Pan M, Guo Q, Xu X, Hu X, Zhou Y, Mo S, Wang H, Gao J, Huang S, Liu Y, Cai S, Hua G, Peng J, Yu FX.

Protein Cell. 2020 Apr;11(4):292-298. doi: 10.1007/s13238-020-00691-0. No abstract available.


Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer.

Yao Y, Xu X, Yang L, Zhu J, Wan J, Shen L, Xia F, Fu G, Deng Y, Pan M, Guo Q, Gao X, Li Y, Rao X, Zhou Y, Liang L, Wang Y, Zhang J, Zhang H, Li G, Zhang L, Peng J, Cai S, Hu C, Gao J, Clevers H, Zhang Z, Hua G.

Cell Stem Cell. 2020 Jan 2;26(1):17-26.e6. doi: 10.1016/j.stem.2019.10.010. Epub 2019 Nov 21.


A novel human colon signet-ring cell carcinoma organoid line: establishment, characterization and application.

Li Y, Wang R, Huang D, Ma X, Mo S, Guo Q, Fu G, Li Y, Xu X, Hu X, Zhou Y, Deng Y, Zhang L, Chen H, Gao J, Zhang Z, Cai S, Hua G, Peng J.

Carcinogenesis. 2019 Nov 19. pii: bgz178. doi: 10.1093/carcin/bgz178. [Epub ahead of print]


Organoids Reveal That Inherent Radiosensitivity of Small and Large Intestinal Stem Cells Determines Organ Sensitivity.

Martin ML, Adileh M, Hsu KS, Hua G, Lee SG, Li C, Fuller JD, Rotolo JA, Bodo S, Klingler S, Haimovitz-Friedman A, Deasy JO, Fuks Z, Paty PB, Kolesnick RN.

Cancer Res. 2020 Mar 1;80(5):1219-1227. doi: 10.1158/0008-5472.CAN-19-0312. Epub 2019 Nov 5.


Malignant ascites-derived organoid (MADO) cultures for gastric cancer in vitro modelling and drug screening.

Li J, Xu H, Zhang L, Song L, Feng D, Peng X, Wu M, Zou Y, Wang B, Zhan L, Hua G, Zhan X.

J Cancer Res Clin Oncol. 2019 Nov;145(11):2637-2647. doi: 10.1007/s00432-019-03004-z. Epub 2019 Oct 9.


Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice.

Guo Q, Chen S, Rao X, Li Y, Pan M, Fu G, Yao Y, Gao X, Tang P, Zhou Y, Xu X, Gao J, Hua G.

Am J Transl Res. 2019 Aug 15;11(8):4789-4799. eCollection 2019.


Application of Chitosan in Bone and Dental Engineering.

Aguilar A, Zein N, Harmouch E, Hafdi B, Bornert F, Offner D, Clauss F, Fioretti F, Huck O, Benkirane-Jessel N, Hua G.

Molecules. 2019 Aug 19;24(16). pii: E3009. doi: 10.3390/molecules24163009. Review.


Polymer-Based Instructive Scaffolds for Endodontic Regeneration.

Zein N, Harmouch E, Lutz JC, Fernandez De Grado G, Kuchler-Bopp S, Clauss F, Offner D, Hua G, Benkirane-Jessel N, Fioretti F.

Materials (Basel). 2019 Jul 24;12(15). pii: E2347. doi: 10.3390/ma12152347. Review.


Activated B Lymphocyte Inhibited the Osteoblastogenesis of Bone Mesenchymal Stem Cells by Notch Signaling.

Pan M, Hong W, Yao Y, Gao X, Zhou Y, Fu G, Li Y, Guo Q, Rao X, Tang P, Chen S, Jin W, Hua G, Gao J, Xu X.

Stem Cells Int. 2019 Jun 2;2019:8150123. doi: 10.1155/2019/8150123. eCollection 2019.


Glucocorticoid receptor modulators CpdX and CpdX-D3 exhibit the same in vivo antiinflammatory activities as synthetic glucocorticoids.

Hua G, Zein N, Daubeuf F, Chambon P.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14191-14199. doi: 10.1073/pnas.1908258116. Epub 2019 Jun 21.


The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids.

Hua G, Zein N, Paulen L, Chambon P.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14200-14209. doi: 10.1073/pnas.1908264116. Epub 2019 Jun 20.


Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury.

Bodo S, Campagne C, Thin TH, Higginson DS, Vargas HA, Hua G, Fuller JD, Ackerstaff E, Russell J, Zhang Z, Klingler S, Cho H, Kaag MG, Mazaheri Y, Rimner A, Manova-Todorova K, Epel B, Zatcky J, Cleary CR, Rao SS, Yamada Y, Zelefsky MJ, Halpern HJ, Koutcher JA, Cordon-Cardo C, Greco C, Haimovitz-Friedman A, Sala E, Powell SN, Kolesnick R, Fuks Z.

J Clin Invest. 2019 Feb 1;129(2):786-801. doi: 10.1172/JCI97631. Epub 2019 Jan 14.


Engineered Soluble Monomeric IgG1 Fc with Significantly Decreased Non-Specific Binding.

Wang C, Wu Y, Wang L, Hong B, Jin Y, Hu D, Chen G, Kong Y, Huang A, Hua G, Ying T.

Front Immunol. 2017 Nov 13;8:1545. doi: 10.3389/fimmu.2017.01545. eCollection 2017.


Logarithmic expansion of LGR5+ cells in human colorectal cancer.

Martin ML, Zeng Z, Adileh M, Jacobo A, Li C, Vakiani E, Hua G, Zhang L, Haimovitz-Friedman A, Fuks Z, Kolesnick R, Paty PB.

Cell Signal. 2018 Jan;42:97-105. doi: 10.1016/j.cellsig.2017.09.018. Epub 2017 Sep 25.


Dysregulated systemic lymphocytes affect the balance of osteogenic/adipogenic differentiation of bone mesenchymal stem cells after local irradiation.

Xu X, Li R, Zhou Y, Zou Q, Ding Q, Wang J, Jin W, Hua G, Gao J.

Stem Cell Res Ther. 2017 Mar 20;8(1):71. doi: 10.1186/s13287-017-0527-0.


Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells.

Hua G, Wang C, Pan Y, Zeng Z, Lee SG, Martin ML, Haimovitz-Friedman A, Fuks Z, Paty PB, Kolesnick R.

Cancer Res. 2017 Apr 15;77(8):2124-2133. doi: 10.1158/0008-5472.CAN-15-2870. Epub 2017 Feb 15.


Bone marrow stem cell dysfunction in radiation-induced abscopal bone loss.

Zou Q, Hong W, Zhou Y, Ding Q, Wang J, Jin W, Gao J, Hua G, Xu X.

J Orthop Surg Res. 2016 Jan 7;11:3. doi: 10.1186/s13018-015-0339-9.


Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex.

Hua G, Ganti KP, Chambon P.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E635-43. doi: 10.1073/pnas.1522826113. Epub 2015 Dec 28.


GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression.

Hua G, Paulen L, Chambon P.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E626-34. doi: 10.1073/pnas.1522821113. Epub 2015 Dec 28.


Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.

Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM.

Nature. 2015 Dec 24;528(7583):560-564. doi: 10.1038/nature16460. Epub 2015 Dec 9.

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