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Items: 1 to 20 of 270


Feedback activation of EGFR is the main cause for STAT3 inhibition-irresponsiveness in pancreatic cancer cells.

Zhao C, Yang L, Zhou F, Yu Y, Du X, Xiang Y, Li C, Huang X, Xie C, Liu Z, Lin J, Wang L, Liang G, Cui R.

Oncogene. 2020 Apr 2. doi: 10.1038/s41388-020-1271-y. [Epub ahead of print]


Selective targeting of the TLR4 co-receptor, MD2, prevents colon cancer growth and lung metastasis.

Rajamanickam V, Yan T, Xu S, Hui J, Xu X, Ren L, Liu Z, Liang G, Wang O, Wang Y.

Int J Biol Sci. 2020 Feb 17;16(8):1288-1302. doi: 10.7150/ijbs.39098. eCollection 2020.


A novel topoisomerase I inhibitor DIA-001 induces DNA damage mediated cell cycle arrest and apoptosis in cancer cell.

Liu J, Geng G, Liang G, Wang L, Luo K, Yuan J, Zhao S.

Ann Transl Med. 2020 Feb;8(4):89. doi: 10.21037/atm.2019.12.138.


The imidazopyridine derivative X22 prevents diabetic kidney dysfunction through inactivating NF-κB signaling.

Jiang Y, Yang L, Yang X, Yin S, Zhuang F, Liu Z, Wang Y, Liang G, Qian J.

Biochem Biophys Res Commun. 2020 Mar 11. pii: S0006-291X(20)30487-3. doi: 10.1016/j.bbrc.2020.03.016. [Epub ahead of print]


Macrophage-derived myeloid differentiation protein 2 plays an essential role in ox-LDL-induced inflammation and atherosclerosis.

Chen T, Huang W, Qian J, Luo W, Shan P, Cai Y, Lin K, Wu G, Liang G.

EBioMedicine. 2020 Mar;53:102706. doi: 10.1016/j.ebiom.2020.102706. Epub 2020 Mar 6.


Escherichia coli adhesion portion FimH functions as an adjuvant for cancer immunotherapy.

Zhang W, Xu L, Park HB, Hwang J, Kwak M, Lee PCW, Liang G, Zhang X, Xu J, Jin JO.

Nat Commun. 2020 Mar 4;11(1):1187. doi: 10.1038/s41467-020-15030-4.


Celastrol Attenuates Angiotensin II-Induced Cardiac Remodeling by Targeting STAT3.

Ye S, Luo W, Khan ZA, Wu G, Xuan L, Shan P, Lin K, Chen T, Wang J, Hu X, Wang S, Huang W, Liang G.

Circ Res. 2020 Feb 26. doi: 10.1161/CIRCRESAHA.119.315861. [Epub ahead of print]


miR-196b-5p-mediated downregulation of TSPAN12 and GATA6 promotes tumor progression in non-small cell lung cancer.

Liang G, Meng W, Huang X, Zhu W, Yin C, Wang C, Fassan M, Yu Y, Kudo M, Xiao S, Zhao C, Zou P, Wang Y, Li X, Croce CM, Cui R.

Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4347-4357. doi: 10.1073/pnas.1917531117. Epub 2020 Feb 10.


Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.

Rajamanickam V, Yan T, Wu L, Zhao Y, Xu X, Zhu H, Chen X, Wang M, Liu Z, Liu Z, Liang G, Wang Y.

Cancer Manag Res. 2020 Jan 13;12:247-263. doi: 10.2147/CMAR.S227415. eCollection 2020.


Compound 15c, a Novel Dual Inhibitor of EGFRL858R/T790M and FGFR1, Efficiently Overcomes Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance of Non-Small-Cell Lung Cancers.

Chen G, Bao Y, Weng Q, Zhao Y, Lu X, Fu L, Chen L, Liu Z, Zhang X, Liang G.

Front Pharmacol. 2020 Jan 10;10:1533. doi: 10.3389/fphar.2019.01533. eCollection 2019.


Palladium-Catalyzed Direct Mono- or Polyhalogenation of Benzothiadiazole Derivatives.

He H, Guo J, Sun W, Yang B, Zhang F, Liang G.

J Org Chem. 2020 Mar 6;85(5):3788-3798. doi: 10.1021/acs.joc.9b03418. Epub 2020 Feb 18.


Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation.

Chen L, Marsiglia WM, Chen H, Katigbak J, Erdjument-Bromage H, Kemble DJ, Fu L, Ma J, Sun G, Zhang Y, Liang G, Neubert TA, Li X, Traaseth NJ, Mohammadi M.

Nat Chem Biol. 2020 Mar;16(3):267-277. doi: 10.1038/s41589-019-0455-7. Epub 2020 Jan 20.


Arachidonic acid inhibits inflammatory responses by binding to myeloid differentiation factor-2 (MD2) and preventing MD2/toll-like receptor 4 signaling activation.

Zhang Y, Chen H, Zhang W, Cai Y, Shan P, Wu D, Zhang B, Liu H, Khan ZA, Liang G.

Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165683. doi: 10.1016/j.bbadis.2020.165683. Epub 2020 Jan 14.


Metal-free regioselective C-H chalcogenylation of coumarins/(hetero)arenes at ambient temperature.

Song Z, Ding C, Wang S, Dai Q, Sheng Y, Zheng Z, Liang G.

Chem Commun (Camb). 2020 Feb 11;56(12):1847-1850. doi: 10.1039/c9cc09001k. Epub 2020 Jan 17.


Curcumin Analogs Reduce Stress and Inflammation Indices in Experimental Models of Diabetes.

Biswas S, Chen S, Liang G, Feng B, Cai L, Khan ZA, Chakrabarti S.

Front Endocrinol (Lausanne). 2019 Dec 18;10:887. doi: 10.3389/fendo.2019.00887. eCollection 2019.


CHK2-FOXK axis promotes transcriptional control of autophagy programs.

Chen Y, Wu J, Liang G, Geng G, Zhao F, Yin P, Nowsheen S, Wu C, Li Y, Li L, Kim W, Zhou Q, Huang J, Liu J, Zhang C, Guo G, Deng M, Tu X, Gao X, Liu Z, Chen Y, Lou Z, Luo K, Yuan J.

Sci Adv. 2020 Jan 1;6(1):eaax5819. doi: 10.1126/sciadv.aax5819. eCollection 2020 Jan.


Myeloid Differentiation Protein 2 Mediates Angiotensin II-Induced Liver Inflammation and Fibrosis in Mice.

Zhang Y, Liu H, Jia W, Qi J, Zhang W, Zhang W, Liang G, Zhang Y, Chen AH.

Molecules. 2019 Dec 19;25(1). pii: E25. doi: 10.3390/molecules25010025.


Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury.

Xiao Z, Xu F, Zhu X, Bai B, Guo L, Liang G, Shan X, Zhang Y, Zhao Y, Zhang B.

Drug Des Devel Ther. 2019 Dec 10;13:4161-4171. doi: 10.2147/DDDT.S215712. eCollection 2019.


Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer.

Wang L, Wang C, Tao Z, Zhao L, Zhu Z, Wu W, He Y, Chen H, Zheng B, Huang X, Yu Y, Yang L, Liang G, Cui R, Chen T.

J Exp Clin Cancer Res. 2019 Nov 8;38(1):460. doi: 10.1186/s13046-019-1424-4.


Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice.

Zheng C, Huang L, Luo W, Yu W, Hu X, Guan X, Cai Y, Zou C, Yin H, Xu Z, Liang G, Wang Y.

Cell Death Dis. 2019 Nov 7;10(11):848. doi: 10.1038/s41419-019-2085-0.

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