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Nutr J. 2015 Jun 16;14:59. doi: 10.1186/s12937-015-0036-x.

Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients--a randomized controlled trial.

Author information

1
Post Graduate Program, Federal Universityof Rio de Janeiro, Professor Rodolpho Paulo Rocco St, 225, Rio de Janeiro, Brazil. beta_franca_carvalho@yahoo.com.br.
2
Post Graduate Program, Federal Universityof Rio de Janeiro, Professor Rodolpho Paulo Rocco St, 225, Rio de Janeiro, Brazil. grazielle.huguenin@gmail.com.
3
Institute of Public Health Studies, Federal Universityof Rio de Janeiro, Jorge Machado Moreira Square, 100, Rio de Janeiro, Brazil. ronir@iesc.ufrj.br.
4
ClinicofAtherosclerosisand Cardiovascular DiseasePrevention, National Cardiology Institute, Laranjeiras St, 374, Rio de Janeiro, Brazil. anniebello@gmail.com.
5
Post Graduate Program, Federal Universityof Rio de Janeiro, Professor Rodolpho Paulo Rocco St, 225, Rio de Janeiro, Brazil. glauciamoraesoliveira@gmail.com.
6
Post Graduate Program, Federal Universityof Rio de Janeiro, Professor Rodolpho Paulo Rocco St, 225, Rio de Janeiro, Brazil. glorimar@nutricao.ufrj.br.
7
Nutrition and Dietetic Department, Josué de Castro Institute of Nutrition, Federal Universityof Rio de Janeiro, 373, 2nd floor, block J, Carlos Chagas FilhoAv, Ilha do Governador, 21941-902, Rio de Janeiro, Brazil. glorimar@nutricao.ufrj.br.

Abstract

OBJECTIVE:

Thyroid hormones can lower levels of atherogenic lipoproteins, and selenium is important in thyroid hormone homeostasis. We aimed to investigate the effects of a healthy diet associated with the Brazil nut (Bertholletia excelsa) in dyslipidemic and hypertensive patients.

METHODS:

This study was a randomized, placebo-controlled, double-blind trial. Seventy-seven dyslipidemic and hypertensive patients already receiving lipid-lowering drugs received either a dietary treatment associated with partially defatted Brazil nut flour (13 g/day providing 227,5 μg of selenium/day),or with dyed cassava flour as a placebo. All patients received a personalized dietary guideline with nutritional recommendations for dyslipidemia and hypertension and were followed for 90 days.

RESULTS:

The Brazil nut group showed reductions in total cholesterol (-20.5 ± 61.2 mg/dL, P = 0.02), non HDL-cholesterol (-19.5 ± 61.2 mg/dL, P = 0.02) and Apo A-1 (-10.2 ± 26.7 mg/dL, P = 0.03) without significant alterations in the Apo B/Apo A-1 ratio. The placebo group showed a reduction in FT3 levels (-0.1 ± 0.4, P = 0.03) and increased Lp(a) levels (5.9 ± 18.0 mg/dL, P = 0.02). There were no statistical differences in blood pressure and serum lipids between Brazil nut and placebo group.

CONCLUSIONS:

Supplementation with Brazil nuts seems to favor the maintenance of FT3 levels and contributes to lipemia reduction in hypercholesterolemic and euthyroid patients.

TRIAL REGISTRATION:

ClinicalTrials.gov Identifier NCT01990391.

PMID:
26077768
PMCID:
PMC4488974
DOI:
10.1186/s12937-015-0036-x
[Indexed for MEDLINE]
Free PMC Article

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