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Items: 1 to 20 of 48


Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis.

Runfola M, Sestito S, Bellusci L, La Pietra V, D'Amore VM, Kowalik MA, Chiellini G, Gul S, Perra A, Columbano A, Marinelli L, Novellino E, Rapposelli S.

Eur J Med Chem. 2019 Dec 23;188:112006. doi: 10.1016/j.ejmech.2019.112006. [Epub ahead of print]


Ultrastructural Localization of Histidine-rich Glycoprotein in Skeletal Muscle Fibers: Colocalization With AMP Deaminase.

Mattii L, Bianchi F, Falleni A, Frascarelli S, Masini M, Alì G, Chiellini G, Sabbatini ARM.

J Histochem Cytochem. 2019 Dec 27:22155419897573. doi: 10.1369/0022155419897573. [Epub ahead of print]


Lipolytic Effects of 3-Iodothyronamine (T1AM) and a Novel Thyronamine-Like Analog SG-2 through the AMPK Pathway.

Rogowski M, Bellusci L, Sabatini M, Rapposelli S, Rahman SM, Chiellini G, Assadi-Porter FM.

Int J Mol Sci. 2019 Aug 20;20(16). pii: E4054. doi: 10.3390/ijms20164054.


Brain Histamine Modulates the Antidepressant-Like Effect of the 3-Iodothyroacetic Acid (TA1).

Laurino A, Landucci E, Cinci L, Gencarelli M, De Siena G, Bellusci L, Chiellini G, Raimondi L.

Front Cell Neurosci. 2019 May 8;13:176. doi: 10.3389/fncel.2019.00176. eCollection 2019.


Multi-targeted ChEI-copper chelating molecules as neuroprotective agents.

Sestito S, Wang S, Chen Q, Lu J, Bertini S, Pomelli C, Chiellini G, He X, Pi R, Rapposelli S.

Eur J Med Chem. 2019 Jul 15;174:216-225. doi: 10.1016/j.ejmech.2019.04.060. Epub 2019 Apr 23.


Editorial: Thyroid Hormone and Metabolites: Central Versus Peripheral Effects.

Chiellini G, Cioffi F, Senese R, de Lange P.

Front Endocrinol (Lausanne). 2019 Apr 16;10:240. doi: 10.3389/fendo.2019.00240. eCollection 2019. No abstract available.


Memantine prodrug as a new agent for Alzheimer's Disease.

Sestito S, Daniele S, Pietrobono D, Citi V, Bellusci L, Chiellini G, Calderone V, Martini C, Rapposelli S.

Sci Rep. 2019 Mar 15;9(1):4612. doi: 10.1038/s41598-019-40925-8.


New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective.

Sestito S, Runfola M, Tonelli M, Chiellini G, Rapposelli S.

Front Pharmacol. 2018 Aug 3;9:874. doi: 10.3389/fphar.2018.00874. eCollection 2018.


Metabolic Reprogramming by 3-Iodothyronamine (T1AM): A New Perspective to Reverse Obesity through Co-Regulation of Sirtuin 4 and 6 Expression.

Assadi-Porter FM, Reiland H, Sabatini M, Lorenzini L, Carnicelli V, Rogowski M, Selen Alpergin ES, Tonelli M, Ghelardoni S, Saba A, Zucchi R, Chiellini G.

Int J Mol Sci. 2018 May 22;19(5). pii: E1535. doi: 10.3390/ijms19051535.


New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection.

Bellusci L, Laurino A, Sabatini M, Sestito S, Lenzi P, Raimondi L, Rapposelli S, Biagioni F, Fornai F, Salvetti A, Rossi L, Zucchi R, Chiellini G.

Front Pharmacol. 2017 Dec 12;8:905. doi: 10.3389/fphar.2017.00905. eCollection 2017.


Recovery of 3-Iodothyronamine and Derivatives in Biological Matrixes: Problems and Pitfalls.

Lorenzini L, Ghelardoni S, Saba A, Sacripanti G, Chiellini G, Zucchi R.

Thyroid. 2017 Oct;27(10):1323-1331. doi: 10.1089/thy.2017.0111.


GC-1: A Thyromimetic With Multiple Therapeutic Applications in Liver Disease.

Columbano A, Chiellini G, Kowalik MA.

Gene Expr. 2017 Nov 27;17(4):265-275. doi: 10.3727/105221617X14968563796227. Epub 2017 Jun 13. Review.


Effects of Thyroid Hormones and their Metabolites on Learning and Memory in Normal and Pathological Conditions.

Accorroni A, Chiellini G, Origlia N.

Curr Drug Metab. 2017;18(3):225-236. doi: 10.2174/1389200218666170116112407. Review.


Metabolic profiling reveals reprogramming of lipid metabolic pathways in treatment of polycystic ovary syndrome with 3-iodothyronamine.

Selen Alpergin ES, Bolandnazar Z, Sabatini M, Rogowski M, Chiellini G, Zucchi R, Assadi-Porter FM.

Physiol Rep. 2017 Jan;5(1). pii: e13097. doi: 10.14814/phy2.13097.


Thyronamines and Analogues - The Route from Rediscovery to Translational Research on Thyronergic Amines.

Chiellini G, Bellusci L, Sabatini M, Zucchi R.

Mol Cell Endocrinol. 2017 Dec 15;458:149-155. doi: 10.1016/j.mce.2017.01.002. Epub 2017 Jan 6. Review.


Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells.

Daniele S, Sestito S, Pietrobono D, Giacomelli C, Chiellini G, Di Maio D, Marinelli L, Novellino E, Martini C, Rapposelli S.

ACS Chem Neurosci. 2017 Jan 18;8(1):100-114. doi: 10.1021/acschemneuro.6b00251. Epub 2016 Nov 10.


Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study.

Chiellini G, Nesi G, Sestito S, Chiarugi S, Runfola M, Espinoza S, Sabatini M, Bellusci L, Laurino A, Cichero E, Gainetdinov RR, Fossa P, Raimondi L, Zucchi R, Rapposelli S.

J Med Chem. 2016 Nov 10;59(21):9825-9836. Epub 2016 Oct 21.


Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists.

Chiellini G, Nesi G, Digiacomo M, Malvasi R, Espinoza S, Sabatini M, Frascarelli S, Laurino A, Cichero E, Macchia M, Gainetdinov RR, Fossa P, Raimondi L, Zucchi R, Rapposelli S.

J Med Chem. 2015 Jun 25;58(12):5096-107. doi: 10.1021/acs.jmedchem.5b00526. Epub 2015 Jun 5.


In the brain of mice, 3-iodothyronamine (T1AM) is converted into 3-iodothyroacetic acid (TA1) and it is included within the signaling network connecting thyroid hormone metabolites with histamine.

Laurino A, De Siena G, Saba A, Chiellini G, Landucci E, Zucchi R, Raimondi L.

Eur J Pharmacol. 2015 Aug 15;761:130-4. doi: 10.1016/j.ejphar.2015.04.038. Epub 2015 May 1.


Cardioprotection by ranolazine in perfused rat heart.

Ghelardoni S, Chiellini G, Frascarelli S, Zucchi R.

J Cardiovasc Pharmacol. 2014 Dec;64(6):507-13. doi: 10.1097/FJC.0000000000000144.


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