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Items: 1 to 20 of 140


Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics.

Xie C, Slagboom J, Albulescu LO, Bruyneel B, Still KBM, Vonk FJ, Somsen GW, Casewell NR, Kool J.

Toxins (Basel). 2020 Jan 16;12(1). pii: E53. doi: 10.3390/toxins12010053.


Analytics for Bioactivity Profiling of Complex Mixtures with a Focus on Venoms.

Mladic M, Niessen WMA, Somsen GW, Kool J.

Methods Mol Biol. 2020;2068:27-49. doi: 10.1007/978-1-4939-9845-6_2.


Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation.

Zietek BM, Still KBM, Jaschusch K, Bruyneel B, Ariese F, Brouwer TJF, Luger M, Limburg RJ, Rosier JC, V Iperen DJ, Casewell NR, Somsen GW, Kool J.

Anal Chem. 2019 Aug 20;91(16):10458-10466. doi: 10.1021/acs.analchem.9b01261. Epub 2019 Aug 2.


Computer-aided gradient optimization of hydrophilic interaction liquid chromatographic separations of intact proteins and protein glycoforms.

van Schaick G, Pirok BWJ, Haselberg R, Somsen GW, Gargano AFG.

J Chromatogr A. 2019 Aug 2;1598:67-76. doi: 10.1016/j.chroma.2019.03.038. Epub 2019 Apr 3.


Compound Identification Using Liquid Chromatography and High-Resolution Noncontact Fraction Collection with a Solenoid Valve.

Jonker W, de Vries K, Althuisius N, van Iperen D, Janssen E, Ten Broek R, Houtman C, Zwart N, Hamers T, Lamoree MH, Ooms B, Hidding J, Somsen GW, Kool J.

SLAS Technol. 2019 Dec;24(6):543-555. doi: 10.1177/2472630319848768. Epub 2019 May 16.


Implementation of at-line capillary zone electrophoresis for fast and reliable determination of adenovirus concentrations in vaccine manufacturing.

van Tricht E, Geurink L, Galindo Garre F, Schenning M, Backus H, Germano M, Somsen GW, Sänger-van de Griend CE.

Electrophoresis. 2019 Sep;40(18-19):2277-2284. doi: 10.1002/elps.201900068. Epub 2019 Apr 15.


Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays.

Otvos RA, Still KBM, Somsen GW, Smit AB, Kool J.

SLAS Discov. 2019 Mar;24(3):362-385. doi: 10.1177/2472555218822098. Epub 2019 Jan 25.


Chiral Discrimination of DL-Amino Acids by Trapped Ion Mobility Spectrometry after Derivatization with (+)-1-(9-Fluorenyl)ethyl Chloroformate.

Pérez-Míguez R, Bruyneel B, Castro-Puyana M, Marina ML, Somsen GW, Domínguez-Vega E.

Anal Chem. 2019 Mar 5;91(5):3277-3285. doi: 10.1021/acs.analchem.8b03661. Epub 2019 Feb 12.


Heterogeneity assessment of antibody-derived therapeutics at the intact and middle-up level by low-flow sheathless capillary electrophoresis-mass spectrometry.

Haselberg R, De Vijlder T, Heukers R, Smit MJ, Romijn EP, Somsen GW, Domínguez-Vega E.

Anal Chim Acta. 2018 Dec 31;1044:181-190. doi: 10.1016/j.aca.2018.08.024. Epub 2018 Aug 15.


Fast, selective and quantitative protein profiling of adenovirus-vector based vaccines by ultra-performance liquid chromatography.

van Tricht E, de Raadt P, Verwilligen A, Schenning M, Backus H, Germano M, Somsen GW, Sänger-van de Griend CE.

J Chromatogr A. 2018 Dec 21;1581-1582:25-32. doi: 10.1016/j.chroma.2018.10.045. Epub 2018 Oct 26.


Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing.

Lakayan D, Haselberg R, Gahoual R, Somsen GW, Kool J.

Anal Bioanal Chem. 2018 Dec;410(30):7837-7848. doi: 10.1007/s00216-018-1414-y. Epub 2018 Oct 17.


CE-MS for metabolomics: Developments and applications in the period 2016-2018.

Ramautar R, Somsen GW, de Jong GJ.

Electrophoresis. 2019 Jan;40(1):165-179. doi: 10.1002/elps.201800323. Epub 2018 Oct 1. Review.


Increasing the Separation Capacity of Intact Histone Proteoforms Chromatography Coupling Online Weak Cation Exchange-HILIC to Reversed Phase LC UVPD-HRMS.

Gargano AFG, Shaw JB, Zhou M, Wilkins CS, Fillmore TL, Moore RJ, Somsen GW, Paša-Tolić L.

J Proteome Res. 2018 Nov 2;17(11):3791-3800. doi: 10.1021/acs.jproteome.8b00458. Epub 2018 Oct 8.


Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms.

Zietek BM, Mayar M, Slagboom J, Bruyneel B, Vonk FJ, Somsen GW, Casewell NR, Kool J.

Anal Bioanal Chem. 2018 Sep;410(23):5751-5763. doi: 10.1007/s00216-018-1253-x. Epub 2018 Aug 9.


Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins.

Vanzolini KL, Ainsworth S, Bruyneel B, Herzig V, Seraus MGL, Somsen GW, Casewell NR, Cass QB, Kool J.

Toxicon. 2018 Sep 15;152:1-8. doi: 10.1016/j.toxicon.2018.06.080. Epub 2018 Jul 7.


Linking the concentrations of itraconazole and 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids after oral intake of Sporanox®.

Berben P, Stappaerts J, Vink MJA, Domínguez-Vega E, Somsen GW, Brouwers J, Augustijns P.

Eur J Pharm Biopharm. 2018 Nov;132:231-236. doi: 10.1016/j.ejpb.2018.06.025. Epub 2018 Jun 27.


Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry.

Wang L, Zhao Y, Zhang Y, Zhang T, Kool J, Somsen GW, Wang Q, Jiang Z.

J Chromatogr A. 2018 Aug 17;1563:135-143. doi: 10.1016/j.chroma.2018.05.069. Epub 2018 May 30.


Chiral capillary electrophoresis with UV-excited fluorescence detection for the enantioselective analysis of 9-fluorenylmethoxycarbonyl-derivatized amino acids.

Prior A, Coliva G, de Jong GJ, Somsen GW.

Anal Bioanal Chem. 2018 Aug;410(20):4979-4990. doi: 10.1007/s00216-018-1148-x. Epub 2018 May 29.


Enantioselective micellar electrokinetic chromatography of dl-amino acids using (+)-1-(9-fluorenyl)-ethyl chloroformate derivatization and UV-induced fluorescence detection.

Prior A, van de Nieuwenhuijzen E, de Jong GJ, Somsen GW.

J Sep Sci. 2018 May 22. doi: 10.1002/jssc.201800204. [Epub ahead of print]


Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling.

Slagboom J, Otvos RA, Cardoso FC, Iyer J, Visser JC, van Doodewaerd BR, McCleary RJR, Niessen WMA, Somsen GW, Lewis RJ, Kini RM, Smit AB, Casewell NR, Kool J.

Toxicon. 2018 Jun 15;148:213-222. doi: 10.1016/j.toxicon.2018.04.022. Epub 2018 May 4.

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