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Items: 16


Sustainable Elimination (Zero Cases) of Sleeping Sickness: How Far Are We from Achieving This Goal?

Akazue PI, Ebiloma GU, Ajibola O, Isaac C, Onyekwelu K, Ezeh CO, Eze AA.

Pathogens. 2019 Aug 29;8(3). pii: E135. doi: 10.3390/pathogens8030135. Review.


European propolis is highly active against trypanosomatids including Crithidia fasciculata.

Alotaibi A, Ebiloma GU, Williams R, Alenezi S, Donachie AM, Guillaume S, Igoli JO, Fearnley J, de Koning HP, Watson DG.

Sci Rep. 2019 Aug 6;9(1):11364. doi: 10.1038/s41598-019-47840-y.


Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan propolis.

Siheri W, Ebiloma GU, Igoli JO, Gray AI, Biddau M, Akrachalanont P, Alenezi S, Alwashih MA, Edrada-Ebel R, Muller S, Lawrence CE, Fearnley J, Watson DG, De Koning HP.

Molecules. 2019 Mar 15;24(6). pii: E1041. doi: 10.3390/molecules24061041.


Alternative oxidase inhibitors: Mitochondrion-targeting as a strategy for new drugs against pathogenic parasites and fungi.

Ebiloma GU, Balogun EO, Cueto-Díaz EJ, de Koning HP, Dardonville C.

Med Res Rev. 2019 Sep;39(5):1553-1602. doi: 10.1002/med.21560. Epub 2019 Jan 29. Review.


Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei.

Cerone M, Uliassi E, Prati F, Ebiloma GU, Lemgruber L, Bergamini C, Watson DG, de A M Ferreira T, Roth Cardoso GSH, Soares Romeiro LA, de Koning HP, Bolognesi ML.

ChemMedChem. 2019 Mar 22;14(6):621-635. doi: 10.1002/cmdc.201800790. Epub 2019 Feb 5.


Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs.

Nnadi CO, Ebiloma GU, Black JA, Nwodo NJ, Lemgruber L, Schmidt TJ, de Koning HP.

Molecules. 2019 Jan 12;24(2). pii: E268. doi: 10.3390/molecules24020268.


SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase.

Meco-Navas A, Ebiloma GU, Martín-Domínguez A, Martínez-Benayas I, Cueto-Díaz EJ, Alhejely AS, Balogun EO, Saito M, Matsui M, Arai N, Shiba T, Harada S, de Koning HP, Dardonville C.

ACS Med Chem Lett. 2018 Jul 31;9(9):923-928. doi: 10.1021/acsmedchemlett.8b00282. eCollection 2018 Sep 13.


Multi-target mode of action of a Clerodane-type diterpenoid from Polyalthia longifolia targeting African trypanosomes.

Ebiloma GU, Katsoulis E, Igoli JO, Gray AI, De Koning HP.

Sci Rep. 2018 Mar 15;8(1):4613. doi: 10.1038/s41598-018-22908-3.


Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.

Ebiloma GU, Ayuga TD, Balogun EO, Gil LA, Donachie A, Kaiser M, Herraiz T, Inaoka DK, Shiba T, Harada S, Kita K, de Koning HP, Dardonville C.

Eur J Med Chem. 2018 Apr 25;150:385-402. doi: 10.1016/j.ejmech.2018.02.075. Epub 2018 Feb 26.


Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.

Millan CR, Acosta-Reyes FJ, Lagartera L, Ebiloma GU, Lemgruber L, Nué Martínez JJ, Saperas N, Dardonville C, de Koning HP, Campos JL.

Nucleic Acids Res. 2017 Aug 21;45(14):8378-8391. doi: 10.1093/nar/gkx521.


The Chemical Characterization of Nigerian Propolis samples and Their Activity Against Trypanosoma brucei.

Omar R, Igoli JO, Zhang T, Gray AI, Ebiloma GU, Clements CJ, Fearnley J, Edrada Ebel R, Paget T, de Koning HP, Watson DG.

Sci Rep. 2017 Apr 19;7(1):923. doi: 10.1038/s41598-017-01038-2.


9-(2'-Deoxy-2'-Fluoro-β-d-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance.

Ranjbarian F, Vodnala M, Alzahrani KJH, Ebiloma GU, de Koning HP, Hofer A.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02719-16. doi: 10.1128/AAC.02719-16. Print 2017 Jun.


Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.

Fueyo González FJ, Ebiloma GU, Izquierdo García C, Bruggeman V, Sánchez Villamañán JM, Donachie A, Balogun EO, Inaoka DK, Shiba T, Harada S, Kita K, de Koning HP, Dardonville C.

J Med Chem. 2017 Feb 23;60(4):1509-1522. doi: 10.1021/acs.jmedchem.6b01740. Epub 2017 Feb 9.


Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.

Rodenko B, Wanner MJ, Alkhaldi AA, Ebiloma GU, Barnes RL, Kaiser M, Brun R, McCulloch R, Koomen GJ, de Koning HP.

Antimicrob Agents Chemother. 2015 Nov;59(11):6708-16. doi: 10.1128/AAC.00596-15. Epub 2015 Aug 17.


Lowering the pKa of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro.

Ríos Martínez CH, Nué Martínez JJ, Ebiloma GU, de Koning HP, Alkorta I, Dardonville C.

Eur J Med Chem. 2015 Aug 28;101:806-17. doi: 10.1016/j.ejmech.2015.07.013. Epub 2015 Jul 10.


Design and synthesis of a series of truncated neplanocin fleximers.

Zimmermann SC, O'Neill E, Ebiloma GU, Wallace LJ, De Koning HP, Seley-Radtke KL.

Molecules. 2014 Dec 16;19(12):21200-14. doi: 10.3390/molecules191221200.

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