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A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure.

Bradley JM, Li Z, Organ CL, Polhemus DJ, Otsuka H, Islam KN, Bhushan S, Gorodnya OM, Ruchko MV, Gillespie MN, Wilson GL, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H311-H321. doi: 10.1152/ajpheart.00515.2017. Epub 2017 Nov 3.


Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-Tracheal Pseudomonas Aeruginosa.

Lee YL, Obiako B, Gorodnya OM, Ruchko MV, Kuck JL, Pastukh VM, Wilson GL, Simmons JD, Gillespie MN.

Shock. 2017 Jul;48(1):54-60. doi: 10.1097/SHK.0000000000000838.


Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.

Guarini G, Kiyooka T, Ohanyan V, Pung YF, Marzilli M, Chen YR, Chen CL, Kang PT, Hardwick JP, Kolz CL, Yin L, Wilson GL, Shokolenko I, Dobson JG Jr, Fenton R, Chilian WM.

Basic Res Cardiol. 2016 May;111(3):29. doi: 10.1007/s00395-016-0547-4. Epub 2016 Apr 4.


Dilution Effect of Intra-articular Injection Administered After Knee Arthroscopy.

Stopka SS, Wilson GL, Pearsall AW.

J Surg Orthop Adv. 2015 Winter;24(4):209-12.


Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis.

Yuzefovych LV, Kahn AG, Schuler MA, Eide L, Arora R, Wilson GL, Tan M, Rachek LI.

Cancer Res. 2016 Jan 1;76(1):30-4. doi: 10.1158/0008-5472.CAN-15-0692. Epub 2015 Nov 19.


A method for mutagenesis of mouse mtDNA and a resource of mouse mtDNA mutations for modeling human pathological conditions.

Fayzulin RZ, Perez M, Kozhukhar N, Spadafora D, Wilson GL, Alexeyev MF.

Nucleic Acids Res. 2015 May 19;43(9):e62. doi: 10.1093/nar/gkv140. Epub 2015 Mar 27.


Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion.

Yang XM, Cui L, White J, Kuck J, Ruchko MV, Wilson GL, Alexeyev M, Gillespie MN, Downey JM, Cohen MV.

Basic Res Cardiol. 2015 Mar;110(2):3. doi: 10.1007/s00395-014-0459-0. Epub 2015 Jan 17.


Aging: A mitochondrial DNA perspective, critical analysis and an update.

Shokolenko IN, Wilson GL, Alexeyev MF.

World J Exp Med. 2014 Nov 20;4(4):46-57. eCollection 2014 Nov 20. Review.


Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice.

Hashizume M, Mouner M, Chouteau JM, Gorodnya OM, Ruchko MV, Wilson GL, Gillespie MN, Parker JC.

Pharmaceuticals (Basel). 2014 Aug 22;7(8):894-912. doi: 10.3390/ph7080894.


The "fast" and the "slow" modes of mitochondrial DNA degradation.

Shokolenko IN, Wilson GL, Alexeyev MF.

Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27(1):490-8. doi: 10.3109/19401736.2014.905829. Epub 2014 Apr 14.


Mitochondrial DNA damage via augmented oxidative stress regulates endoplasmic reticulum stress and autophagy: crosstalk, links and signaling.

Yuzefovych LV, LeDoux SP, Wilson GL, Rachek LI.

PLoS One. 2013 Dec 13;8(12):e83349. doi: 10.1371/journal.pone.0083349. eCollection 2013.


Mitochondrial DNA ligase is dispensable for the viability of cultured cells but essential for mtDNA maintenance.

Shokolenko IN, Fayzulin RZ, Katyal S, McKinnon PJ, Wilson GL, Alexeyev MF.

J Biol Chem. 2013 Sep 13;288(37):26594-605. doi: 10.1074/jbc.M113.472977. Epub 2013 Jul 24.


Alteration of mitochondrial function and insulin sensitivity in primary mouse skeletal muscle cells isolated from transgenic and knockout mice: role of ogg1.

Yuzefovych LV, Schuler AM, Chen J, Alvarez DF, Eide L, Ledoux SP, Wilson GL, Rachek LI.

Endocrinology. 2013 Aug;154(8):2640-9. doi: 10.1210/en.2013-1076. Epub 2013 Jun 7.


Persistent damage induces mitochondrial DNA degradation.

Shokolenko IN, Wilson GL, Alexeyev MF.

DNA Repair (Amst). 2013 Jul;12(7):488-99. doi: 10.1016/j.dnarep.2013.04.023. Epub 2013 May 27.


Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways.

Wang H, Cai S, Ernstberger A, Bailey BJ, Wang MZ, Cai W, Goebel WS, Czader MB, Crean C, Suvannasankha A, Shokolenkoc I, Wilson GL, Baluyut AR, Mayo LD, Pollok KE.

Clin Cancer Res. 2013 May 15;19(10):2699-709. doi: 10.1158/1078-0432.CCR-12-2671. Epub 2013 Mar 27.


Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice.

Hashizume M, Mouner M, Chouteau JM, Gorodnya OM, Ruchko MV, Potter BJ, Wilson GL, Gillespie MN, Parker JC.

Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15;304(4):L287-97. doi: 10.1152/ajplung.00071.2012. Epub 2012 Dec 14.


Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism.

Ding Y, Liu Z, Desai S, Zhao Y, Liu H, Pannell LK, Yi H, Wright ER, Owen LB, Dean-Colomb W, Fodstad O, Lu J, LeDoux SP, Wilson GL, Tan M.

Nat Commun. 2012;3:1271. doi: 10.1038/ncomms2236.


Mitochondrial DNA damage mediates hyperoxic dysmorphogenesis in rat fetal lung explants.

Gebb SA, Decoux A, Waggoner A, Wilson GL, Gillespie MN.

Neonatology. 2013;103(2):91-7. doi: 10.1159/000342632. Epub 2012 Nov 15.


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