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Untargeted rat brain metabolomics after oral administration of a single high dose of cannabidiol.

Citti C, Palazzoli F, Licata M, Vilella A, Leo G, Zoli M, Vandelli MA, Forni F, Pacchetti B, Cannazza G.

J Pharm Biomed Anal. 2018 Aug 11;161:1-11. doi: 10.1016/j.jpba.2018.08.021. [Epub ahead of print]


Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine.

De Backer JF, Monlezun S, Detraux B, Gazan A, Vanopdenbosch L, Cheron J, Cannazza G, Valverde S, Cantacorps L, Nassar M, Venance L, Valverde O, Faure P, Zoli M, De Backer O, Gall D, Schiffmann SN, de Kerchove d'Exaerde A.

EMBO Rep. 2018 Sep;19(9). pii: e45089. doi: 10.15252/embr.201745089. Epub 2018 Jul 12.


Quality Traits of "Cannabidiol Oils": Cannabinoids Content, Terpene Fingerprint and Oxidation Stability of European Commercially Available Preparations.

Pavlovic R, Nenna G, Calvi L, Panseri S, Borgonovo G, Giupponi L, Cannazza G, Giorgi A.

Molecules. 2018 May 20;23(5). pii: E1230. doi: 10.3390/molecules23051230.


Polymeric Nano-Micelles as Novel Cargo-Carriers for LY2157299 Liver Cancer Cells Delivery.

Hanafy NAN, Quarta A, Ferraro MM, Dini L, Nobile C, De Giorgi ML, Carallo S, Citti C, Gaballo A, Cannazza G, Rinaldi R, Giannelli G, Leporatti S.

Int J Mol Sci. 2018 Mar 6;19(3). pii: E748. doi: 10.3390/ijms19030748.


Cell-Penetrating CaCO₃ Nanocrystals for Improved Transport of NVP-BEZ235 across Membrane Barrier in T-Cell Lymphoma.

Vergaro V, Civallero M, Citti C, Cosenza M, Baldassarre F, Cannazza G, Pozzi S, Sacchi S, Fanizzi FP, Ciccarella G.

Cancers (Basel). 2018 Jan 25;10(2). pii: E31. doi: 10.3390/cancers10020031.


Inihibition of Glycolysis by Using a Micro/Nano-Lipid Bromopyruvic Chitosan Carrier as a Promising Tool to Improve Treatment of Hepatocellular Carcinoma.

Hanafy NA, Dini L, Citti C, Cannazza G, Leporatti S.

Nanomaterials (Basel). 2018 Jan 10;8(1). pii: E34. doi: 10.3390/nano8010034.


Development of a simple and sensitive liquid chromatography triple quadrupole mass spectrometry (LC-MS/MS) method for the determination of cannabidiol (CBD), Δ9-tetrahydrocannabinol (THC) and its metabolites in rat whole blood after oral administration of a single high dose of CBD.

Palazzoli F, Citti C, Licata M, Vilella A, Manca L, Zoli M, Vandelli MA, Forni F, Cannazza G.

J Pharm Biomed Anal. 2018 Feb 20;150:25-32. doi: 10.1016/j.jpba.2017.11.054. Epub 2017 Nov 28.


Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA).

Citti C, Pacchetti B, Vandelli MA, Forni F, Cannazza G.

J Pharm Biomed Anal. 2018 Feb 5;149:532-540. doi: 10.1016/j.jpba.2017.11.044. Epub 2017 Nov 20.


Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.

Linciano P, Dawson A, Pöhner I, Costa DM, Sá MS, Cordeiro-da-Silva A, Luciani R, Gul S, Witt G, Ellinger B, Kuzikov M, Gribbon P, Reinshagen J, Wolf M, Behrens B, Hannaert V, Michels PAM, Nerini E, Pozzi C, di Pisa F, Landi G, Santarem N, Ferrari S, Saxena P, Lazzari S, Cannazza G, Freitas-Junior LH, Moraes CB, Pascoalino BS, Alcântara LM, Bertolacini CP, Fontana V, Wittig U, Müller W, Wade RC, Hunter WN, Mangani S, Costantino L, Costi MP.

ACS Omega. 2017 Sep 30;2(9):5666-5683. doi: 10.1021/acsomega.7b00473. Epub 2017 Sep 11.


A Metabolomic Approach Applied to a Liquid Chromatography Coupled to High-Resolution Tandem Mass Spectrometry Method (HPLC-ESI-HRMS/MS): Towards the Comprehensive Evaluation of the Chemical Composition of Cannabis Medicinal Extracts.

Citti C, Battisti UM, Braghiroli D, Ciccarella G, Schmid M, Vandelli MA, Cannazza G.

Phytochem Anal. 2018 Mar;29(2):144-155. doi: 10.1002/pca.2722. Epub 2017 Sep 15.


Pharmaceutical and biomedical analysis of cannabinoids: A critical review.

Citti C, Braghiroli D, Vandelli MA, Cannazza G.

J Pharm Biomed Anal. 2018 Jan 5;147:565-579. doi: 10.1016/j.jpba.2017.06.003. Epub 2017 Jun 4. Review.


Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants.

Borsini A, Alboni S, Horowitz MA, Tojo LM, Cannazza G, Su KP, Pariante CM, Zunszain PA.

Brain Behav Immun. 2017 Oct;65:230-238. doi: 10.1016/j.bbi.2017.05.006. Epub 2017 May 18.


Probing an Allosteric Pocket of CDK2 with Small Molecules.

Christodoulou MS, Caporuscio F, Restelli V, Carlino L, Cannazza G, Costanzi E, Citti C, Lo Presti L, Pisani P, Battistutta R, Broggini M, Passarella D, Rastelli G.

ChemMedChem. 2017 Jan 5;12(1):33-41. doi: 10.1002/cmdc.201600474. Epub 2016 Dec 19.


Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments.

Besson M, Guiducci S, Granon S, Guilloux JP, Guiard B, Repérant C, Faure P, Pons S, Cannazza G, Zoli M, Gardier AM, Maskos U.

Psychopharmacology (Berl). 2016 Sep;233(18):3297-314. doi: 10.1007/s00213-016-4362-2. Epub 2016 Jul 6.


Medicinal cannabis: Principal cannabinoids concentration and their stability evaluated by a high performance liquid chromatography coupled to diode array and quadrupole time of flight mass spectrometry method.

Citti C, Ciccarella G, Braghiroli D, Parenti C, Vandelli MA, Cannazza G.

J Pharm Biomed Anal. 2016 Sep 5;128:201-209. doi: 10.1016/j.jpba.2016.05.033. Epub 2016 May 20.


Analytical and preparative enantioseparation and main chiroptical properties of Iridium(III) bis(4,6-difluorophenylpyridinato)picolinato.

Citti C, Battisti UM, Ciccarella G, Maiorano V, Gigli G, Abbate S, Mazzeo G, Castiglioni E, Longhi G, Cannazza G.

J Chromatogr A. 2016 Oct 7;1467:335-346. doi: 10.1016/j.chroma.2016.05.059. Epub 2016 May 19.


"Heart-cut" bidimensional achiral-chiral liquid chromatography applied to the evaluation of stereoselective metabolism, in vivo biological activity and brain response to chiral drug candidates targeting the central nervous system.

Battisti UM, Citti C, Larini M, Ciccarella G, Stasiak N, Troisi L, Braghiroli D, Parenti C, Zoli M, Cannazza G.

J Chromatogr A. 2016 Apr 22;1443:152-61. doi: 10.1016/j.chroma.2016.03.027. Epub 2016 Mar 14.


7-Chloro-5-(furan-3-yl)-3-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-Dioxide as Positive Allosteric Modulator of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor. The End of the Unsaturated-Inactive Paradigm?

Citti C, Battisti UM, Cannazza G, Jozwiak K, Stasiak N, Puja G, Ravazzini F, Ciccarella G, Braghiroli D, Parenti C, Troisi L, Zoli M.

ACS Chem Neurosci. 2016 Feb 17;7(2):149-60. doi: 10.1021/acschemneuro.5b00257. Epub 2015 Dec 2.


Internalization and stability of a thymidylate synthase Peptide inhibitor in ovarian cancer cells.

Cannazza G, Cazzato AS, Marraccini C, Pavesi G, Pirondi S, Guerrini R, Pelà M, Frassineti C, Ferrari S, Marverti G, Ponterini G, Costi MP.

J Med Chem. 2014 Dec 26;57(24):10551-6. doi: 10.1021/jm501397h. Epub 2014 Dec 3.


Design, stereoselective synthesis, configurational stability and biological activity of 7-chloro-9-(furan-3-yl)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide.

Carrozzo MM, Battisti UM, Cannazza G, Puia G, Ravazzini F, Falchicchio A, Perrone S, Citti C, Jozwiak K, Braghiroli D, Parenti C, Troisi L.

Bioorg Med Chem. 2014 Sep 1;22(17):4667-76. doi: 10.1016/j.bmc.2014.07.017. Epub 2014 Jul 18.


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