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Items: 1 to 20 of 35

1.

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis.

Riva B, Griglio A, Serafini M, Cordero-Sanchez C, Aprile S, Di Paola R, Gugliandolo E, Alansary D, Biocotino I, Lim D, Grosa G, Galli U, Niemeyer B, Sorba G, Canonico PL, Cuzzocrea S, Genazzani AA, Pirali T.

J Med Chem. 2018 Nov 8;61(21):9756-9783. doi: 10.1021/acs.jmedchem.8b01512. Epub 2018 Oct 30.

PMID:
30347159
2.

Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders.

Serafini M, Griglio A, Aprile S, Seiti F, Travelli C, Pattarino F, Grosa G, Sorba G, Genazzani AA, Gonzalez-Rodriguez S, Butron L, Devesa I, Fernandez-Carvajal A, Pirali T, Ferrer-Montiel A.

J Med Chem. 2018 May 24;61(10):4436-4455. doi: 10.1021/acs.jmedchem.8b00109. Epub 2018 May 15.

PMID:
29722529
3.

A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies.

Griglio A, Torre E, Serafini M, Bianchi A, Schmid R, Coda Zabetta G, Massarotti A, Sorba G, Pirali T, Fallarini S.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):651-657. doi: 10.1016/j.bmcl.2018.01.032. Epub 2018 Feb 2.

PMID:
29398544
4.

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC.

ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31.

5.

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

Travelli C, Aprile S, Rahimian R, Grolla AA, Rogati F, Bertolotti M, Malagnino F, di Paola R, Impellizzeri D, Fusco R, Mercalli V, Massarotti A, Stortini G, Terrazzino S, Del Grosso E, Fakhfouri G, Troiani MP, Alisi MA, Grosa G, Sorba G, Canonico PL, Orsomando G, Cuzzocrea S, Genazzani AA, Galli U, Tron GC.

J Med Chem. 2017 Mar 9;60(5):1768-1792. doi: 10.1021/acs.jmedchem.6b01392. Epub 2017 Feb 22.

PMID:
28165742
6.

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors.

Galli U, Ciraolo E, Massarotti A, Margaria JP, Sorba G, Hirsch E, Tron GC.

Molecules. 2015 Sep 18;20(9):17275-87. doi: 10.3390/molecules200917275.

7.

Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents.

Galli U, Travelli C, Aprile S, Arrigoni E, Torretta S, Grosa G, Massarotti A, Sorba G, Canonico PL, Genazzani AA, Tron GC.

J Med Chem. 2015 Feb 12;58(3):1345-57. doi: 10.1021/jm5016389. Epub 2015 Jan 27.

PMID:
25584687
8.

Are 1,4- and 1,5-disubstituted 1,2,3-triazoles good pharmacophoric groups?

Massarotti A, Aprile S, Mercalli V, Del Grosso E, Grosa G, Sorba G, Tron GC.

ChemMedChem. 2014 Nov;9(11):2497-508. doi: 10.1002/cmdc.201402233. Epub 2014 Jul 30.

PMID:
25079879
9.

ZINClick: a database of 16 million novel, patentable, and readily synthesizable 1,4-disubstituted triazoles.

Massarotti A, Brunco A, Sorba G, Tron GC.

J Chem Inf Model. 2014 Feb 24;54(2):396-406. doi: 10.1021/ci400529h. Epub 2014 Jan 31.

PMID:
24451008
10.

A concise synthesis of pyrazole analogues of combretastatin A1 as potent anti-tubulin agents.

Zaninetti R, Cortese SV, Aprile S, Massarotti A, Canonico PL, Sorba G, Grosa G, Genazzani AA, Pirali T.

ChemMedChem. 2013 Apr;8(4):633-43. doi: 10.1002/cmdc.201200561. Epub 2013 Feb 21.

PMID:
23436706
11.

Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus.

Bassetto M, De Burghgraeve T, Delang L, Massarotti A, Coluccia A, Zonta N, Gatti V, Colombano G, Sorba G, Silvestri R, Tron GC, Neyts J, Leyssen P, Brancale A.

Antiviral Res. 2013 Apr;98(1):12-8. doi: 10.1016/j.antiviral.2013.01.002. Epub 2013 Feb 1.

PMID:
23380636
12.

De novo computer-aided design of novel antiviral agents.

Massarotti A, Coluccia A, Sorba G, Silvestri R, Brancale A.

Drug Discov Today Technol. 2012 Autumn;9(3):e213-8. doi: 10.1016/j.ddtec.2011.11.008.

PMID:
24990574
13.

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.

Galli U, Mesenzani O, Coppo C, Sorba G, Canonico PL, Tron GC, Genazzani AA.

Eur J Med Chem. 2012 Sep;55:58-66. doi: 10.1016/j.ejmech.2012.07.001. Epub 2012 Jul 15.

PMID:
22835719
14.

The tubulin colchicine domain: a molecular modeling perspective.

Massarotti A, Coluccia A, Silvestri R, Sorba G, Brancale A.

ChemMedChem. 2012 Jan 2;7(1):33-42. doi: 10.1002/cmdc.201100361. Epub 2011 Oct 12. Review.

PMID:
21990124
15.

Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors.

Guasconi M, Lu X, Massarotti A, Caldarelli A, Ciraolo E, Tron GC, Hirsch E, Sorba G, Pirali T.

Org Biomol Chem. 2011 Jun 7;9(11):4144-9. doi: 10.1039/c1ob05336a. Epub 2011 Apr 14.

PMID:
21494711
16.

Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.

Mesenzani O, Massarotti A, Giustiniano M, Pirali T, Bevilacqua V, Caldarelli A, Canonico P, Sorba G, Novellino E, Genazzani AA, Tron GC.

Bioorg Med Chem Lett. 2011 Jan 15;21(2):764-8. doi: 10.1016/j.bmcl.2010.11.113. Epub 2010 Nov 28.

PMID:
21167709
17.

Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.

Ciraolo E, Morello F, Hobbs RM, Wolf F, Marone R, Iezzi M, Lu X, Mengozzi G, Altruda F, Sorba G, Guan K, Pandolfi PP, Wymann MP, Hirsch E.

Mol Biol Cell. 2010 Mar 1;21(5):704-11. doi: 10.1091/mbc.E09-08-0744. Epub 2010 Jan 6.

18.

A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry.

Colombano G, Travelli C, Galli U, Caldarelli A, Chini MG, Canonico PL, Sorba G, Bifulco G, Tron GC, Genazzani AA.

J Med Chem. 2010 Jan 28;53(2):616-23. doi: 10.1021/jm9010669.

PMID:
19961183
19.

Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases.

Grolla AA, Podestà V, Chini MG, Di Micco S, Vallario A, Genazzani AA, Canonico PL, Bifulco G, Tron GC, Sorba G, Pirali T.

J Med Chem. 2009 May 14;52(9):2776-85. doi: 10.1021/jm801529c.

PMID:
19344175
20.

Solution-phase parallel synthesis and biological evaluation of combretatriazoles.

Cafici L, Pirali T, Condorelli F, Del Grosso E, Massarotti A, Sorba G, Canonico PL, Tron GC, Genazzani AA.

J Comb Chem. 2008 Sep-Oct;10(5):732-40. doi: 10.1021/cc800090d. Epub 2008 Aug 6.

PMID:
18681482

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