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Items: 1 to 20 of 34


N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells.

Zuhra K, Tomé CS, Masi L, Giardina G, Paulini G, Malagrinò F, Forte E, Vicente JB, Giuffrè A.

Cells. 2019 Aug 4;8(8). pii: E828. doi: 10.3390/cells8080828.


R180T variant of δ-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.

Montioli R, Paiardini A, Giardina G, Zanzoni S, Cutruzzola F, Cellini B, Borri Voltattorni C.

FEBS J. 2019 Jul;286(14):2787-2798. doi: 10.1111/febs.14843. Epub 2019 Apr 15.


The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.

Guiducci G, Paone A, Tramonti A, Giardina G, Rinaldo S, Bouzidi A, Magnifico MC, Marani M, Menendez JA, Fatica A, Macone A, Armaos A, Tartaglia GG, Contestabile R, Paiardini A, Cutruzzolà F.

Nucleic Acids Res. 2019 May 7;47(8):4240-4254. doi: 10.1093/nar/gkz129.


Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.

Mantoni F, Paiardini A, Brunotti P, D'Angelo C, Cervoni L, Paone A, Cappellacci L, Petrelli R, Ricciutelli M, Leoni L, Rampioni G, Arcovito A, Rinaldo S, Cutruzzolà F, Giardina G.

FEBS J. 2018 Oct;285(20):3815-3834. doi: 10.1111/febs.14634. Epub 2018 Sep 7.


The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.

Giardina G, Paone A, Tramonti A, Lucchi R, Marani M, Magnifico MC, Bouzidi A, Pontecorvi V, Guiducci G, Zamparelli C, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.

FEBS J. 2018 Sep;285(17):3238-3253. doi: 10.1111/febs.14610. Epub 2018 Aug 7.


Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.

Tramonti A, Paiardini A, Paone A, Bouzidi A, Giardina G, Guiducci G, Magnifico MC, Rinaldo S, McDermott L, Menendez JA, Contestabile R, Cutruzzolà F.

Arch Biochem Biophys. 2018 Sep 1;653:71-79. doi: 10.1016/ Epub 2018 Jul 4.


Beyond nitrogen metabolism: nitric oxide, cyclic-di-GMP and bacterial biofilms.

Rinaldo S, Giardina G, Mantoni F, Paone A, Cutruzzolà F.

FEMS Microbiol Lett. 2018 Mar 1;365(6). doi: 10.1093/femsle/fny029. Review.


Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.

Giardina G, Paiardini A, Montioli R, Cellini B, Voltattorni CB, Cutruzzolà F.

Sci Rep. 2017 Sep 15;7(1):11704. doi: 10.1038/s41598-017-11948-w.


Glucose Metabolism in the Progression of Prostate Cancer.

Cutruzzolà F, Giardina G, Marani M, Macone A, Paiardini A, Rinaldo S, Paone A.

Front Physiol. 2017 Feb 21;8:97. doi: 10.3389/fphys.2017.00097. eCollection 2017. Review.


New Insights Emerging from Recent Investigations on Human Group II Pyridoxal 5'-Phosphate Decarboxylases.

Paiardini A, Giardina G, Rossignoli G, Voltattorni CB, Bertoldi M.

Curr Med Chem. 2017;24(3):226-244. doi: 10.2174/0929867324666161123093339. Review.


A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.

Marani M, Paone A, Fiascarelli A, Macone A, Gargano M, Rinaldo S, Giardina G, Pontecorvi V, Koes D, McDermott L, Yang T, Paiardini A, Contestabile R, Cutruzzolà F.

Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726.


Synthesis of Triazole-Linked Analogues of c-di-GMP and Their Interactions with Diguanylate Cyclase.

Fernicola S, Torquati I, Paiardini A, Giardina G, Rampioni G, Messina M, Leoni L, Del Bello F, Petrelli R, Rinaldo S, Cappellacci L, Cutruzzolà F.

J Med Chem. 2015 Oct 22;58(20):8269-84. doi: 10.1021/acs.jmedchem.5b01184. Epub 2015 Oct 12.


In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD.

Fernicola S, Paiardini A, Giardina G, Rampioni G, Leoni L, Cutruzzolà F, Rinaldo S.

J Bacteriol. 2015 Sep 28;198(1):147-56. doi: 10.1128/JB.00742-15. Print 2016 Jan 1.


Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site.

Rinaldo S, Paiardini A, Stelitano V, Brunotti P, Cervoni L, Fernicola S, Protano C, Vitali M, Cutruzzolà F, Giardina G.

J Bacteriol. 2015 Apr;197(8):1525-35. doi: 10.1128/JB.02606-14. Epub 2015 Feb 17.


Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.

Paiardini A, Fiascarelli A, Rinaldo S, Daidone F, Giardina G, Koes DR, Parroni A, Montini G, Marani M, Paone A, McDermott LA, Contestabile R, Cutruzzolà F.

ChemMedChem. 2015 Mar;10(3):490-7. doi: 10.1002/cmdc.201500028. Epub 2015 Feb 10.


How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.

Giardina G, Brunotti P, Fiascarelli A, Cicalini A, Costa MG, Buckle AM, di Salvo ML, Giorgi A, Marani M, Paone A, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.

FEBS J. 2015 Apr;282(7):1225-41. doi: 10.1111/febs.13211. Epub 2015 Feb 13.


Nitrosylation of c heme in cd(1)-nitrite reductase is enhanced during catalysis.

Rinaldo S, Giardina G, Cutruzzolà F.

Biochem Biophys Res Commun. 2014 Aug 29;451(3):449-54. doi: 10.1016/j.bbrc.2014.08.020. Epub 2014 Aug 10.


Distal-proximal crosstalk in the heme binding pocket of the NO sensor DNR.

Cutruzzolà F, Arcovito A, Giardina G, della Longa S, D'Angelo P, Rinaldo S.

Biometals. 2014 Aug;27(4):763-73. doi: 10.1007/s10534-014-9770-3. Epub 2014 Jul 10.


Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: clues from the structure of the catalytic domain.

Giardina G, Paiardini A, Fernicola S, Franceschini S, Rinaldo S, Stelitano V, Cutruzzolà F.

PLoS One. 2013 Nov 22;8(11):e81324. doi: 10.1371/journal.pone.0081324. eCollection 2013.


C-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpG.

Stelitano V, Giardina G, Paiardini A, Castiglione N, Cutruzzolà F, Rinaldo S.

PLoS One. 2013 Sep 16;8(9):e74920. doi: 10.1371/journal.pone.0074920. eCollection 2013.

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