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Items: 18


miR-23b Modulates the Epithelial-Mesenchymal Transition of Colorectal Cancer Cells.

Gasiulė S, Dreize N, Kaupinis A, Ražanskas R, Čiupas L, Stankevičius V, Kapustina Ž, Laurinavičius A, Valius M, Vilkaitis G.

J Clin Med. 2019 Dec 2;8(12). pii: E2115. doi: 10.3390/jcm8122115.


Tissue-Specific miRNAs Regulate the Development of Thoracic Aortic Aneurysm: The Emerging Role of KLF4 Network.

Gasiulė S, Stankevičius V, Patamsytė V, Ražanskas R, Žukovas G, Kapustina Ž, Žaliaduonytė D, Benetis R, Lesauskaitė V, Vilkaitis G.

J Clin Med. 2019 Oct 3;8(10). pii: E1609. doi: 10.3390/jcm8101609.


Repurposing enzymatic transferase reactions for targeted labeling and analysis of DNA and RNA.

Tomkuvienė M, Mickutė M, Vilkaitis G, Klimašauskas S.

Curr Opin Biotechnol. 2019 Feb;55:114-123. doi: 10.1016/j.copbio.2018.09.008. Epub 2018 Oct 6. Review.


Animal Hen1 2'-O-methyltransferases as tools for 3'-terminal functionalization and labelling of single-stranded RNAs.

Mickute M, Nainyte M, Vasiliauskaite L, Plotnikova A, Masevicius V, Klimašauskas S, Vilkaitis G.

Nucleic Acids Res. 2018 Sep 28;46(17):e104. doi: 10.1093/nar/gky514.


Oligonucleotide-Addressed Covalent 3'-Terminal Derivatization of Small RNA Strands for Enrichment and Visualization.

Osipenko A, Plotnikova A, Nainytė M, Masevičius V, Klimašauskas S, Vilkaitis G.

Angew Chem Int Ed Engl. 2017 Jun 1;56(23):6507-6510. doi: 10.1002/anie.201701448. Epub 2017 May 4.


Splicing-dependent expression of microRNAs of mirtron origin in human digestive and excretory system cancer cells.

Butkytė S, Čiupas L, Jakubauskienė E, Vilys L, Mocevicius P, Kanopka A, Vilkaitis G.

Clin Epigenetics. 2016 Mar 25;8:33. doi: 10.1186/s13148-016-0200-y. eCollection 2016.


Gastrointestinal tract tumors and cell lines possess differential splicing factor expression and tumor associated mRNA isoform formation profiles.

Jakubauskienė E, Peciuliene I, Vilys L, Mocevicius P, Vilkaitis G, Kanopka A.

Cancer Biomark. 2015;15(5):575-81. doi: 10.3233/CBM-150497.


Functional mapping of the plant small RNA methyltransferase: HEN1 physically interacts with HYL1 and DICER-LIKE 1 proteins.

Baranauskė S, Mickutė M, Plotnikova A, Finke A, Venclovas Č, Klimašauskas S, Vilkaitis G.

Nucleic Acids Res. 2015 Mar 11;43(5):2802-12. doi: 10.1093/nar/gkv102. Epub 2015 Feb 12.


Selective covalent labeling of miRNA and siRNA duplexes using HEN1 methyltransferase.

Plotnikova A, Osipenko A, Masevičius V, Vilkaitis G, Klimašauskas S.

J Am Chem Soc. 2014 Oct 1;136(39):13550-3. doi: 10.1021/ja507390s. Epub 2014 Sep 19.


Mechanistic insights into small RNA recognition and modification by the HEN1 methyltransferase.

Plotnikova A, Baranauskė S, Osipenko A, Klimašauskas S, Vilkaitis G.

Biochem J. 2013 Jul 15;453(2):281-90. doi: 10.1042/BJ20121699.


Kinetic and functional analysis of the small RNA methyltransferase HEN1: the catalytic domain is essential for preferential modification of duplex RNA.

Vilkaitis G, Plotnikova A, Klimasauskas S.

RNA. 2010 Oct;16(10):1935-42. doi: 10.1261/rna.2281410. Epub 2010 Aug 12.


A directed evolution design of a GCG-specific DNA hemimethylase.

Gerasimaite R, Vilkaitis G, Klimasauskas S.

Nucleic Acids Res. 2009 Nov;37(21):7332-41. doi: 10.1093/nar/gkp772.


Approaches for studying microRNA and small interfering RNA methylation in vitro and in vivo.

Yang Z, Vilkaitis G, Yu B, Klimasauskas S, Chen X.

Methods Enzymol. 2007;427:139-54.


Processive methylation of hemimethylated CpG sites by mouse Dnmt1 DNA methyltransferase.

Vilkaitis G, Suetake I, Klimasauskas S, Tajima S.

J Biol Chem. 2005 Jan 7;280(1):64-72. Epub 2004 Oct 27.


HhaI DNA methyltransferase uses the protruding Gln237 for active flipping of its target cytosine.

Daujotyte D, Serva S, Vilkaitis G, Merkiene E, Venclovas C, Klimasauskas S.

Structure. 2004 Jun;12(6):1047-55.


N4,5-dimethylcytosine, a novel hypermodified base in DNA.

Klimasauskas S, Gerasimaite R, Vilkaitis G, Kulakauskas S.

Nucleic Acids Res Suppl. 2002;(2):73-4.


Solubility engineering of the HhaI methyltransferase.

Daujotyte D, Vilkaitis G, Manelyte L, Skalicky J, Szyperski T, Klimasauskas S.

Protein Eng. 2003 Apr;16(4):295-301.


Circular permutation of DNA cytosine-N4 methyltransferases: in vivo coexistence in the BcnI system and in vitro probing by hybrid formation.

Vilkaitis G, Lubys A, Merkiene E, Timinskas A, Janulaitis A, Klimasauskas S.

Nucleic Acids Res. 2002 Apr 1;30(7):1547-57.

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