Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 67

1.

Aryl azides as forgotten electrophiles in the Van Leusen reaction: a multicomponent transformation affording 4-tosyl-1-arylimidazoles.

Necardo C, Alfano AI, Del Grosso E, Pelliccia S, Galli U, Novellino E, Meneghetti F, Giustiniano M, Tron GC.

J Org Chem. 2019 Nov 29. doi: 10.1021/acs.joc.9b02546. [Epub ahead of print]

PMID:
31779310
2.

Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors.

Velnati S, Massarotti A, Antona A, Talmon M, Fresu LG, Galetto AS, Capello D, Bertoni A, Mercalli V, Graziani A, Tron GC, Baldanzi G.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):96-108. doi: 10.1080/14756366.2019.1684911.

3.

Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group.

Travelli C, Aprile S, Mattoteia D, Colombo G, Clemente N, Scanziani E, Terrazzino S, Alisi MA, Polenzani L, Grosa G, Genazzani AA, Tron GC, Galli U.

Eur J Med Chem. 2019 Nov 1;181:111576. doi: 10.1016/j.ejmech.2019.111576. Epub 2019 Aug 1.

PMID:
31400709
4.

Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives.

Pelliccia S, Amato J, Capasso D, Di Gaetano S, Massarotti A, Piccolo M, Irace C, Tron GC, Pagano B, Randazzo A, Novellino E, Giustiniano M.

J Med Chem. 2019 Jul 10. doi: 10.1021/acs.jmedchem.9b00262. [Epub ahead of print]

PMID:
31241946
5.

Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines.

Galli U, Hysenlika R, Meneghetti F, Del Grosso E, Pelliccia S, Novellino E, Giustiniano M, Tron GC.

Molecules. 2019 May 21;24(10). pii: E1959. doi: 10.3390/molecules24101959.

6.

Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction.

Pirali T, Galli U, Serafini M, Griglio A, Genazzani AA, Tron GC.

Methods Mol Biol. 2019;1987:207-221. doi: 10.1007/978-1-4939-9446-5_13.

PMID:
31028682
7.

Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells.

Travelli C, Consonni FM, Sangaletti S, Storto M, Morlacchi S, Grolla AA, Galli U, Tron GC, Portararo P, Rimassa L, Pressiani T, Mazzone M, Trovato R, Ugel S, Bronte V, Tripodo C, Colombo MP, Genazzani AA, Sica A.

Cancer Res. 2019 Apr 15;79(8):1938-1951. doi: 10.1158/0008-5472.CAN-18-1544. Epub 2019 Feb 18.

PMID:
30777853
8.

Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening.

Velnati S, Ruffo E, Massarotti A, Talmon M, Varma KSS, Gesu A, Fresu LG, Snow AL, Bertoni A, Capello D, Tron GC, Graziani A, Baldanzi G.

Eur J Med Chem. 2019 Feb 15;164:378-390. doi: 10.1016/j.ejmech.2018.12.061. Epub 2018 Dec 26.

9.

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.

Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E.

Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6.

10.

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC.

ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31.

11.

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

Travelli C, Aprile S, Rahimian R, Grolla AA, Rogati F, Bertolotti M, Malagnino F, di Paola R, Impellizzeri D, Fusco R, Mercalli V, Massarotti A, Stortini G, Terrazzino S, Del Grosso E, Fakhfouri G, Troiani MP, Alisi MA, Grosa G, Sorba G, Canonico PL, Orsomando G, Cuzzocrea S, Genazzani AA, Galli U, Tron GC.

J Med Chem. 2017 Mar 9;60(5):1768-1792. doi: 10.1021/acs.jmedchem.6b01392. Epub 2017 Feb 22.

PMID:
28165742
12.

N-N bond formation in Ugi processes: from nitric acid to libraries of nitramines.

Mercalli V, Nyadanu A, Cordier M, Tron GC, Grimaud L, El Kaim L.

Chem Commun (Camb). 2017 Feb 9;53(13):2118-2121. doi: 10.1039/c6cc10288c.

PMID:
28133657
13.

To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis.

Giustiniano M, Basso A, Mercalli V, Massarotti A, Novellino E, Tron GC, Zhu J.

Chem Soc Rev. 2017 Mar 6;46(5):1295-1357. doi: 10.1039/c6cs00444j. Review.

PMID:
27983738
14.

A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids.

Giustiniano M, Pelliccia S, Galli U, Amato J, Travagin F, Novellino E, Tron GC.

J Org Chem. 2016 Nov 18;81(22):11467-11471. Epub 2016 Oct 26.

PMID:
27755877
15.

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors.

Galli U, Ciraolo E, Massarotti A, Margaria JP, Sorba G, Hirsch E, Tron GC.

Molecules. 2015 Sep 18;20(9):17275-87. doi: 10.3390/molecules200917275.

16.

Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement.

Mercalli V, Massarotti A, Varese M, Giustiniano M, Meneghetti F, Novellino E, Tron GC.

J Org Chem. 2015 Oct 2;80(19):9652-61. doi: 10.1021/acs.joc.5b01676. Epub 2015 Sep 30.

PMID:
26360930
17.

Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones.

Giustiniano M, Mercalli V, Amato J, Novellino E, Tron GC.

Org Lett. 2015 Aug 21;17(16):3964-7. doi: 10.1021/acs.orglett.5b01798. Epub 2015 Aug 5.

PMID:
26244260
18.

Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents.

Galli U, Travelli C, Aprile S, Arrigoni E, Torretta S, Grosa G, Massarotti A, Sorba G, Canonico PL, Genazzani AA, Tron GC.

J Med Chem. 2015 Feb 12;58(3):1345-57. doi: 10.1021/jm5016389. Epub 2015 Jan 27.

PMID:
25584687
19.

Solution-phase parallel synthesis of aryloxyimino amides via a novel multicomponent reaction among aromatic (Z)-chlorooximes, isocyanides, and electron-deficient phenols.

Mercalli V, Giustiniano M, Del Grosso E, Varese M, Cassese H, Massarotti A, Novellino E, Tron GC.

ACS Comb Sci. 2014 Nov 10;16(11):602-5. doi: 10.1021/co5000882. Epub 2014 Oct 22.

PMID:
25319356
20.

Synthesis of aminocarbonyl N-acylhydrazones by a three-component reaction of isocyanides, hydrazonoyl chlorides, and carboxylic acids.

Giustiniano M, Meneghetti F, Mercalli V, Varese M, Giustiniano F, Novellino E, Tron GC.

Org Lett. 2014 Oct 17;16(20):5332-5. doi: 10.1021/ol502515b. Epub 2014 Sep 26.

PMID:
25259417

Supplemental Content

Loading ...
Support Center