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Items: 1 to 20 of 97

1.

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog.

Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB.

Nat Commun. 2019 Aug 6;10(1):3533. doi: 10.1038/s41467-019-11389-1.

2.

Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning.

Morningstar J, Lee J, Hendry-Hofer T, Witeof A, Lyle LT, Knipp G, MacRae CA, Boss GR, Peterson RT, Davisson VJ, Gerszten RE, Bebarta VS, Mahon S, Brenner M, Nath AK.

FASEB Bioadv. 2019 Feb;1(2):81-92. doi: 10.1096/fba.1024. Epub 2018 Oct 8.

PMID:
31355359
3.

Efficacy of Oral Administration of Sodium Thiosulfate and Glycine in a Large, Swine Model of Oral Cyanide Toxicity.

Ng PC, Hendry-Hofer TB, Witeof AE, Mahon SB, Brenner M, Boss GR, Bebarta VS.

Ann Emerg Med. 2019 May 9. pii: S0196-0644(19)30242-2. doi: 10.1016/j.annemergmed.2019.03.023. [Epub ahead of print]

PMID:
31080026
4.

Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development.

Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Haouzi P, Bebarta VS.

J Med Toxicol. 2019 May 6. doi: 10.1007/s13181-019-00710-5. [Epub ahead of print] Review.

PMID:
31062177
5.

Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity.

Hendry-Hofer TB, Witeof AE, Ng PC, Mahon SB, Brenner M, Boss GR, Bebarta VS.

Clin Toxicol (Phila). 2019 Apr 22:1-7. doi: 10.1080/15563650.2019.1602272. [Epub ahead of print]

PMID:
31008657
6.

Antidotal efficacies of the cyanide antidote candidate dimethyl trisulfide alone and in combination with cobinamide derivatives.

Petrikovics I, Kiss L, Chou CE, Ebrahimpour A, Kovács K, Kiss M, Logue B, Chan A, Manage ABW, Budai M, Boss GR, Rockwood GA.

Toxicol Mech Methods. 2019 Jul;29(6):438-444. doi: 10.1080/15376516.2019.1585504. Epub 2019 May 6.

PMID:
30822191
7.

A Review on Ingested Cyanide: Risks, Clinical Presentation, Diagnostics, and Treatment Challenges.

Hendry-Hofer TB, Ng PC, Witeof AE, Mahon SB, Brenner M, Boss GR, Bebarta VS.

J Med Toxicol. 2019 Apr;15(2):128-133. doi: 10.1007/s13181-018-0688-y. Epub 2018 Dec 11. Review.

PMID:
30539383
8.

Intramuscular cobinamide versus saline for treatment of severe hydrogen sulfide toxicity in swine.

Ng PC, Hendry-Hofer TB, Garrett N, Brenner M, Mahon SB, Maddry JK, Haouzi P, Boss GR, Gibbons TF, Araña AA, Bebarta VS.

Clin Toxicol (Phila). 2019 Mar;57(3):189-196. doi: 10.1080/15563650.2018.1504955. Epub 2018 Nov 15.

9.

Characterization of a Swine (Sus scrofa) Model of Oral Potassium Cyanide Intoxication.

Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Bebarta VS.

Comp Med. 2018 Oct 1;68(5):375-379. doi: 10.30802/AALAS-CM-18-000041. Epub 2018 Sep 12.

10.

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.

Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA.

PLoS One. 2018 Jun 7;13(6):e0193889. doi: 10.1371/journal.pone.0193889. eCollection 2018.

11.

Faraday Waves-Based Integrated Ultrasonic Micro-Droplet Generator and Applications.

Tsai CS, Mao RW, Tsai SC, Shahverdi K, Zhu Y, Lin SK, Hsu YH, Boss G, Brenner M, Mahon S, Smaldone GC.

Micromachines (Basel). 2017;8(2). pii: 56. doi: 10.3390/mi8020056. Epub 2017 Feb 14.

12.

Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model.

Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK.

Ann N Y Acad Sci. 2017 Nov;1408(1):61-78. doi: 10.1111/nyas.13559.

13.

Development of an Inexpensive RGB Color Sensor for the Detection of Hydrogen Cyanide Gas.

Greenawald LA, Boss GR, Snyder JL, Reeder A, Bell S.

ACS Sens. 2017 Oct 27;2(10):1458-1466. doi: 10.1021/acssensors.7b00396. Epub 2017 Oct 12.

PMID:
28967741
14.

Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion.

Brenner M, Azer SM, Oh KJ, Han CH, Lee J, Mahon SB, Du X, Mukai D, Burney T, Saidian M, Chan A, Straker DI, Bebarta VS, Boss GR.

J Clin Toxicol. 2017 Jun;7(3). pii: 355. doi: 10.4172/2167-7972.1000355. Epub 2017 Jun 27.

15.

Efficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model.

Bebarta VS, Garrett N, Brenner M, Mahon SB, Maddry JK, Boudreau S, Castaneda M, Boss GR.

Acad Emerg Med. 2017 Sep;24(9):1088-1098. doi: 10.1111/acem.13213. Epub 2017 Aug 9.

16.

Cisplatin Analogs Confer Protection against Cyanide Poisoning.

Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT.

Cell Chem Biol. 2017 May 18;24(5):565-575.e4. doi: 10.1016/j.chembiol.2017.03.013. Epub 2017 Apr 13.

17.

Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection.

Bebarta VS, Brittain M, Chan A, Garrett N, Yoon D, Burney T, Mukai D, Babin M, Pilz RB, Mahon SB, Brenner M, Boss GR.

Ann Emerg Med. 2017 Jun;69(6):718-725.e4. doi: 10.1016/j.annemergmed.2016.09.034. Epub 2016 Dec 29.

18.

Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase.

Sahu D, Gupta S, Hau AM, Nakashima K, Leivo MZ, Searles SC, Elson P, Bomalaski JS, Casteel DE, Boss GR, Hansel DE.

Am J Pathol. 2017 Jan;187(1):200-213. doi: 10.1016/j.ajpath.2016.09.004. Epub 2016 Dec 9.

19.

A countermeasure development pipeline.

MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT.

Ann N Y Acad Sci. 2016 Aug;1378(1):58-67. doi: 10.1111/nyas.13224. Review.

20.

The Vitamin B12 Analog Cobinamide Is an Effective Antidote for Oral Cyanide Poisoning.

Lee J, Mahon SB, Mukai D, Burney T, Katebian BS, Chan A, Bebarta VS, Yoon D, Boss GR, Brenner M.

J Med Toxicol. 2016 Dec;12(4):370-379. Epub 2016 Sep 15.

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