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Items: 1 to 20 of 80


Metformin turns off the metabolic switch of pancreatic cancer.

Deschênes-Simard X, Rowell MC, Ferbeyre G.

Aging (Albany NY). 2019 Dec 12;11(23):10793-10795. doi: 10.18632/aging.102622. Epub 2019 Dec 12. No abstract available.


NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor.

Bury M, Le Calvé B, Lessard F, Dal Maso T, Saliba J, Michiels C, Ferbeyre G, Blank V.

Cell Rep. 2019 Nov 5;29(6):1469-1481.e9. doi: 10.1016/j.celrep.2019.09.087.


Cellular Senescence: Defining a Path Forward.

Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M.

Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005. Review.


STAT3 and STAT5 Activation in Solid Cancers.

Igelmann S, Neubauer HA, Ferbeyre G.

Cancers (Basel). 2019 Sep 25;11(10). pii: E1428. doi: 10.3390/cancers11101428. Review.


The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity.

Zhou TE, Zhu T, Rivera JC, Omri S, Tahiri H, Lahaie I, Rouget R, Wirth M, Nattel S, Lodygensky G, Ferbeyre G, Nezhady M, Desjarlais M, Hamel P, Chemtob S.

Am J Pathol. 2019 Nov;189(11):2340-2356. doi: 10.1016/j.ajpath.2019.07.009. Epub 2019 Aug 17.


Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice.

Caland L, Labbé P, Mamarbachi M, Villeneuve L, Ferbeyre G, Noly PE, Carrier M, Thorin-Trescases N, Thorin É.

Aging (Albany NY). 2019 Jun 11;11(11):3832-3850. doi: 10.18632/aging.102020.


Phosphorylation of SOCS1 Inhibits the SOCS1-p53 Tumor Suppressor Axis.

Saint-Germain E, Mignacca L, Huot G, Acevedo M, Moineau-Vallée K, Calabrese V, Bourdeau V, Rowell MC, Ilangumaran S, Lessard F, Ferbeyre G.

Cancer Res. 2019 Jul 1;79(13):3306-3319. doi: 10.1158/0008-5472.CAN-18-1503. Epub 2019 May 17.


Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex.

Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F.

Cell Cycle. 2019 Mar - Apr;18(6-7):759-770. doi: 10.1080/15384101.2019.1593708. Epub 2019 Mar 28.


The senescence-associated secretory phenotype and its regulation.

Lopes-Paciencia S, Saint-Germain E, Rowell MC, Ruiz AF, Kalegari P, Ferbeyre G.

Cytokine. 2019 May;117:15-22. doi: 10.1016/j.cyto.2019.01.013. Epub 2019 Feb 16.


Ribosomal Proteins Control Tumor Suppressor Pathways in Response to Nucleolar Stress.

Lessard F, Brakier-Gingras L, Ferbeyre G.

Bioessays. 2019 Mar;41(3):e1800183. doi: 10.1002/bies.201800183. Epub 2019 Feb 1. Review.


Circumventing senescence is associated with stem cell properties and metformin sensitivity.

Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G.

Aging Cell. 2019 Apr;18(2):e12889. doi: 10.1111/acel.12889. Epub 2019 Jan 6.


Molecular tools that block maturation of the nuclear lamin A and decelerate cancer cell migration.

Matralis AN, Xanthopoulos D, Huot G, Lopes-Paciencia S, Cole C, de Vries H, Ferbeyre G, Tsantrizos YS.

Bioorg Med Chem. 2018 Nov 1;26(20):5547-5554. doi: 10.1016/j.bmc.2018.10.001. Epub 2018 Oct 4.


Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I.

Cell Metab. 2018 Dec 4;28(6):817-832.e8. doi: 10.1016/j.cmet.2018.09.001. Epub 2018 Sep 20.


The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides.

Yan Y, Acevedo M, Mignacca L, Desjardins P, Scott N, Imane R, Quenneville J, Robitaille J, Feghaly A, Gagnon E, Ferbeyre G, Major F.

Nucleic Acids Res. 2018 Sep 19;46(16):8181-8196. doi: 10.1093/nar/gky546.


Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.

Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G.

Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25.


Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9.

McManus FP, Bourdeau V, Acevedo M, Lopes-Paciencia S, Mignacca L, Lamoliatte F, Rojas Pino JW, Ferbeyre G, Thibault P.

Sci Rep. 2018 May 17;8(1):7754. doi: 10.1038/s41598-018-25150-z.


SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes.

Saint-Germain E, Mignacca L, Vernier M, Bobbala D, Ilangumaran S, Ferbeyre G.

Aging (Albany NY). 2017 Oct 28;9(10):2137-2162. doi: 10.18632/aging.101306.


Aberrant signaling and senescence associated protein degradation.

Ferbeyre G.

Exp Gerontol. 2018 Jul 1;107:50-54. doi: 10.1016/j.exger.2017.06.016. Epub 2017 Jun 27. Review.


Senescence gives insights into the morphogenetic evolution of anamniotes.

Villiard É, Denis JF, Hashemi FS, Igelmann S, Ferbeyre G, Roy S.

Biol Open. 2017 Jun 15;6(6):891-896. doi: 10.1242/bio.025809.


Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer.

Chevrier M, Bobbala D, Villalobos-Hernandez A, Khan MG, Ramanathan S, Saucier C, Ferbeyre G, Geha S, Ilangumaran S.

BMC Cancer. 2017 Feb 24;17(1):157. doi: 10.1186/s12885-017-3141-8.

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