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Items: 1 to 20 of 43

1.

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.

Botuyan MV, Cui G, Drané P, Oliveira C, Detappe A, Brault ME, Parnandi N, Chaubey S, Thompson JR, Bragantini B, Zhao D, Chapman JR, Chowdhury D, Mer G.

Nat Struct Mol Biol. 2018 Jul;25(7):591-600. doi: 10.1038/s41594-018-0083-z. Epub 2018 Jul 2.

2.

Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin.

Cui G, Botuyan MV, Mer G.

J Mol Biol. 2018 Jul 6;430(14):2042-2050. doi: 10.1016/j.jmb.2018.05.017. Epub 2018 May 18.

3.

A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction.

Mer G, Botuyan MV.

Structure. 2017 Oct 3;25(10):1471-1472. doi: 10.1016/j.str.2017.09.011. Epub 2017 Oct 3.

4.

Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18.

Hu Q, Botuyan MV, Cui G, Zhao D, Mer G.

Mol Cell. 2017 May 18;66(4):473-487.e9. doi: 10.1016/j.molcel.2017.04.009. Epub 2017 May 11.

5.

TIRR regulates 53BP1 by masking its histone methyl-lysine binding function.

Drané P, Brault ME, Cui G, Meghani K, Chaubey S, Detappe A, Parnandi N, He Y, Zheng XF, Botuyan MV, Kalousi A, Yewdell WT, Münch C, Harper JW, Chaudhuri J, Soutoglou E, Mer G, Chowdhury D.

Nature. 2017 Mar 9;543(7644):211-216. doi: 10.1038/nature21358. Epub 2017 Feb 27.

6.

Stabilization of Nucleosomes by Histone Tails and by FACT Revealed by spFRET Microscopy.

Valieva ME, Gerasimova NS, Kudryashova KS, Kozlova AL, Kirpichnikov MP, Hu Q, Botuyan MV, Mer G, Feofanov AV, Studitsky VM.

Cancers (Basel). 2017 Jan 6;9(1). pii: E3. doi: 10.3390/cancers9010003.

7.

Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas.

Klein CJ, Wu Y, Jentoft ME, Mer G, Spinner RJ, Dyck PJ, Dyck PJ, Mauermann ML.

Ann Neurol. 2017 Feb;81(2):316-321. doi: 10.1002/ana.24854. Epub 2017 Jan 28.

8.

PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.

Klein BJ, Wang X, Cui G, Yuan C, Botuyan MV, Lin K, Lu Y, Wang X, Zhao Y, Bruns CJ, Mer G, Shi X, Kutateladze TG.

Cell Rep. 2016 Oct 18;17(4):1158-1170. doi: 10.1016/j.celrep.2016.09.056.

9.

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.

Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM.

Science. 2016 Sep 30;353(6307):1549-1552.

10.

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders.

Baets J, Duan X, Wu Y, Smith G, Seeley WW, Mademan I, McGrath NM, Beadell NC, Khoury J, Botuyan MV, Mer G, Worrell GA, Hojo K, DeLeon J, Laura M, Liu YT, Senderek J, Weis J, Van den Bergh P, Merrill SL, Reilly MM, Houlden H, Grossman M, Scherer SS, De Jonghe P, Dyck PJ, Klein CJ.

Brain. 2015 Apr;138(Pt 4):845-61. doi: 10.1093/brain/awv010. Epub 2015 Feb 11.

11.

An acetyl-methyl switch drives a conformational change in p53.

Tong Q, Mazur SJ, Rincon-Arano H, Rothbart SB, Kuznetsov DM, Cui G, Liu WH, Gete Y, Klein BJ, Jenkins L, Mer G, Kutateladze AG, Strahl BD, Groudine M, Appella E, Kutateladze TG.

Structure. 2015 Feb 3;23(2):322-31. doi: 10.1016/j.str.2014.12.010.

12.

Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.

Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SV.

ACS Chem Biol. 2015 Apr 17;10(4):1072-81. doi: 10.1021/cb500956g. Epub 2015 Jan 28.

13.

Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1.

Tong Q, Cui G, Botuyan MV, Rothbart SB, Hayashi R, Musselman CA, Singh N, Appella E, Strahl BD, Mer G, Kutateladze TG.

Structure. 2015 Feb 3;23(2):312-21. doi: 10.1016/j.str.2014.11.013. Epub 2015 Jan 8.

14.

Ubiquitin ligase defect by DCAF8 mutation causes HMSN2 with giant axons.

Klein CJ, Wu Y, Vogel P, Goebel HH, Bönnemann C, Zukosky K, Botuyan MV, Duan X, Middha S, Atkinson EJ, Mer G, Dyck PJ.

Neurology. 2014 Mar 11;82(10):873-8. doi: 10.1212/WNL.0000000000000206. Epub 2014 Feb 5.

15.

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.

Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, Greenberg RA.

Nat Struct Mol Biol. 2013 Mar;20(3):317-25. doi: 10.1038/nsmb.2499. Epub 2013 Feb 3.

16.

DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.

Klein CJ, Bird T, Ertekin-Taner N, Lincoln S, Hjorth R, Wu Y, Kwok J, Mer G, Dyck PJ, Nicholson GA.

Neurology. 2013 Feb 26;80(9):824-8. doi: 10.1212/WNL.0b013e318284076d. Epub 2013 Jan 30.

17.

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.

Ramachandran PL, Craig TA, Atanasova EA, Cui G, Owen BA, Bergen HR 3rd, Mer G, Kumar R.

J Biol Chem. 2012 Nov 16;287(47):39439-48. doi: 10.1074/jbc.M112.398495. Epub 2012 Sep 27.

18.

Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.

Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14381-6. doi: 10.1073/pnas.1212366109. Epub 2012 Aug 20.

19.

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.

Cui G, Park S, Badeaux AI, Kim D, Lee J, Thompson JR, Yan F, Kaneko S, Yuan Z, Botuyan MV, Bedford MT, Cheng JQ, Mer G.

Nat Struct Mol Biol. 2012 Sep;19(9):916-24. doi: 10.1038/nsmb.2353. Epub 2012 Aug 5.

20.

(1)H, (15)N and (13)C resonance assignments for the three LOTUS RNA binding domains of Tudor domain-containing protein TDRD7.

Cui G, Botuyan MV, Mer G.

Biomol NMR Assign. 2013 Apr;7(1):79-83. doi: 10.1007/s12104-012-9382-1. Epub 2012 Apr 6.

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