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Items: 1 to 20 of 144


Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches.

Tibbo AJ, Tejeda GS, Baillie GS.

Biochem Soc Trans. 2019 Oct 31;47(5):1557-1565. doi: 10.1042/BST20190763.


Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes.

Blair CM, Baillie GS.

Biochem Soc Trans. 2019 Oct 31;47(5):1405-1414. doi: 10.1042/BST20190252.


Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond.

Baillie GS, Tejeda GS, Kelly MP.

Nat Rev Drug Discov. 2019 Oct;18(10):770-796. doi: 10.1038/s41573-019-0033-4. Epub 2019 Aug 6. Review.


The Association of the Long Prostate Cancer Expressed PDE4D Transcripts to Poor Patient Outcome Depends on the Tumour's TMPRSS2-ERG Fusion Status.

van Strijp D, de Witz C, Heitkötter B, Huss S, Bögemann M, Baillie GS, Houslay MD, Bangma C, Semjonow A, Hoffmann R.

Prostate Cancer. 2019 Jun 2;2019:8107807. doi: 10.1155/2019/8107807. eCollection 2019.


Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.

Omar F, Findlay JE, Carfray G, Allcock RW, Jiang Z, Moore C, Muir AL, Lannoy M, Fertig BA, Mai D, Day JP, Bolger G, Baillie GS, Schwiebert E, Klussmann E, Pyne NJ, Ong ACM, Bowers K, Adam JM, Adams DR, Houslay MD, Henderson DJP.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329. doi: 10.1073/pnas.1822113116. Epub 2019 Jun 17.


A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling.

Vagena E, Ryu JK, Baeza-Raja B, Walsh NM, Syme C, Day JP, Houslay MD, Baillie GS.

Transl Psychiatry. 2019 May 10;9(1):141. doi: 10.1038/s41398-019-0470-1.


AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.

Clister T, Greenwald EC, Baillie GS, Zhang J.

Cell Chem Biol. 2019 Jun 20;26(6):885-891.e4. doi: 10.1016/j.chembiol.2019.03.003. Epub 2019 Apr 11.


PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders.

Whiteley EL, Tejeda GS, Baillie GS, Brandon NJ.

Cell Signal. 2019 Aug;60:31-38. doi: 10.1016/j.cellsig.2019.04.001. Epub 2019 Apr 2. Review.


Methods to Investigate Arrestins in Complex with Phosphodiesterases.

Tibbo AJ, Busiau T, Baillie GS.

Methods Mol Biol. 2019;1957:121-137. doi: 10.1007/978-1-4939-9158-7_8.


Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A - C-Raf.

Blair CM, Walsh NM, Littman BH, Marcoux FW, Baillie GS.

BMC Cancer. 2019 Mar 25;19(1):266. doi: 10.1186/s12885-019-5489-4.


Effect of tacrolimus on skin microbiome in atopic dermatitis.

Wongpiyabovorn J, Soonthornchai W, Wilantho A, Palasuk M, Payungporn S, Sodsai P, Poomipak W, Weschawalit S, Ruchusatsawat K, Baillie GS, Hirankarn N, Somboonna N.

Allergy. 2019 Jul;74(7):1400-1406. doi: 10.1111/all.13743. Epub 2019 Mar 11. No abstract available.


A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase.

Strembitska A, Mancini SJ, Gamwell JM, Palmer TM, Baillie GS, Salt IP.

Int J Mol Sci. 2018 Dec 5;19(12). pii: E3886. doi: 10.3390/ijms19123886.


A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins.

Maziarz M, Broselid S, DiGiacomo V, Park JC, Luebbers A, Garcia-Navarrete L, Blanco-Canosa JB, Baillie GS, Garcia-Marcos M.

J Biol Chem. 2018 Nov 2;293(44):16964-16983. doi: 10.1074/jbc.RA118.003580. Epub 2018 Sep 7.


The Prognostic PDE4D7 Score in a Diagnostic Biopsy Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.

van Strijp D, de Witz C, Vos PC, den Biezen-Timmermans E, van Brussel A, Wrobel J, Baillie GS, Tennstedt P, Schlomm T, Heitkötter B, Huss S, Bögemann M, Houslay MD, Bangma C, Semjonow A, Hoffmann R.

Prostate Cancer. 2018 Jul 26;2018:5821616. doi: 10.1155/2018/5821616. eCollection 2018.


RAB40C regulates RACK1 stability via the ubiquitin-proteasome system.

Day JP, Whiteley E, Freeley M, Long A, Malacrida B, Kiely P, Baillie GS.

Future Sci OA. 2018 Jul 2;4(7):FSO317. doi: 10.4155/fsoa-2018-0022. eCollection 2018 Jul.


PDE4-Mediated cAMP Signalling.

Fertig BA, Baillie GS.

J Cardiovasc Dev Dis. 2018 Jan 31;5(1). pii: E8. doi: 10.3390/jcdd5010008. Review.


Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability.

Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM.

Nat Commun. 2018 Jan 12;9(1):168. doi: 10.1038/s41467-017-02585-y.


Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase.

Lemonidis K, MacLeod R, Baillie GS, Chamberlain LH.

J Biol Chem. 2017 Oct 20;292(42):17190-17202. doi: 10.1074/jbc.M117.799650. Epub 2017 Sep 7.


PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex.

Basole CP, Nguyen RK, Lamothe K, Vang A, Clark R, Baillie GS, Epstein PM, Brocke S.

Cell Signal. 2017 Dec;40:62-72. doi: 10.1016/j.cellsig.2017.08.007. Epub 2017 Aug 26.


Validation of Cyclic Adenosine Monophosphate Phosphodiesterase-4D7 for its Independent Contribution to Risk Stratification in a Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.

Alves de Inda M, van Strijp D, den Biezen-Timmermans E, van Brussel A, Wrobel J, van Zon H, Vos P, Baillie GS, Tennstedt P, Schlomm T, Houslay MD, Bangma C, Hoffmann R.

Eur Urol Focus. 2018 Apr;4(3):376-384. doi: 10.1016/j.euf.2017.05.010. Epub 2017 Jun 13.

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