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Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress.

Hua AB, Justiniano R, Perer J, Park SL, Li H, Cabello CM, Wondrak GT.

Cancers (Basel). 2019 Apr 27;11(5). pii: E590. doi: 10.3390/cancers11050590.


TLR4 in skin cancer: From molecular mechanisms to clinical interventions.

Dickinson SE, Wondrak GT.

Mol Carcinog. 2019 Jul;58(7):1086-1093. doi: 10.1002/mc.23016. Epub 2019 Apr 24.


Sun sensitivity and sun protective behaviors during sun exposure among indoor office workers in the American Midwest.

Jung AM, Dennis LK, Jacobs ET, Wondrak GT.

Photodermatol Photoimmunol Photomed. 2018 Nov;34(6):393-399. doi: 10.1111/phpp.12403. Epub 2018 Jun 25.


Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin.

Rojo de la Vega M, Zhang DD, Wondrak GT.

Front Pharmacol. 2018 Mar 27;9:287. doi: 10.3389/fphar.2018.00287. eCollection 2018.


Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice.

Blohm-Mangone K, Burkett NB, Tahsin S, Myrdal PB, Aodah A, Ho B, Janda J, McComas M, Saboda K, Roe DJ, Dong Z, Bode AM, Petricoin EF 3rd, Calvert VS, Curiel-Lewandrowski C, Alberts DS, Wondrak GT, Dickinson SE.

Cancer Prev Res (Phila). 2018 May;11(5):265-278. doi: 10.1158/1940-6207.CAPR-17-0349. Epub 2018 Feb 1.


Parkinson's Disease Skin Fibroblasts Display Signature Alterations in Growth, Redox Homeostasis, Mitochondrial Function, and Autophagy.

Teves JMY, Bhargava V, Kirwan KR, Corenblum MJ, Justiniano R, Wondrak GT, Anandhan A, Flores AJ, Schipper DA, Khalpey Z, Sligh JE, Curiel-Lewandrowski C, Sherman SJ, Madhavan L.

Front Neurosci. 2018 Jan 12;11:737. doi: 10.3389/fnins.2017.00737. eCollection 2017.


Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin.

Rojo de la Vega M, Krajisnik A, Zhang DD, Wondrak GT.

Nutrients. 2017 Dec 18;9(12). pii: E1371. doi: 10.3390/nu9121371. Review.


TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis.

Dickinson SE, Wondrak GT.

Curr Med Chem. 2018;25(40):5487-5502. doi: 10.2174/0929867324666170828125328. Review.


A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin.

Justiniano R, Perer J, Hua A, Fazel M, Krajisnik A, Cabello CM, Wondrak GT.

Photochem Photobiol. 2017 Nov;93(6):1472-1482. doi: 10.1111/php.12794. Epub 2017 Jul 21.


The B6 -vitamer Pyridoxal is a Sensitizer of UVA-induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis.

Justiniano R, Williams JD, Perer J, Hua A, Lesson J, Park SL, Wondrak GT.

Photochem Photobiol. 2017 Jul;93(4):990-998. doi: 10.1111/php.12720. Epub 2017 Feb 28.


Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin.

Janda J, Burkett NB, Blohm-Mangone K, Huang V, Curiel-Lewandrowski C, Alberts DS, Petricoin EF 3rd, Calvert VS, Einspahr J, Dong Z, Bode AM, Wondrak GT, Dickinson SE.

Photochem Photobiol. 2016 Nov;92(6):816-825. doi: 10.1111/php.12659. Epub 2016 Dec 8.


Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner.

Tao S, Rojo de la Vega M, Quijada H, Wondrak GT, Wang T, Garcia JG, Zhang DD.

Sci Rep. 2016 Jan 5;6:18760. doi: 10.1038/srep18760.


An Essential Role of NRF2 in Diabetic Wound Healing.

Long M, Rojo de la Vega M, Wen Q, Bharara M, Jiang T, Zhang R, Zhou S, Wong PK, Wondrak GT, Zheng H, Zhang DD.

Diabetes. 2016 Mar;65(3):780-93. doi: 10.2337/db15-0564. Epub 2015 Dec 30.


Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2.

Tao S, Park SL, Rojo de la Vega M, Zhang DD, Wondrak GT.

Free Radic Biol Med. 2015 Dec;89:690-700. doi: 10.1016/j.freeradbiomed.2015.08.028. Epub 2015 Nov 4.


Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde.

Long M, Tao S, Rojo de la Vega M, Jiang T, Wen Q, Park SL, Zhang DD, Wondrak GT.

Cancer Prev Res (Phila). 2015 May;8(5):444-54. doi: 10.1158/1940-6207.CAPR-14-0359. Epub 2015 Feb 23.


The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.

Davis AL, Qiao S, Lesson JL, Rojo de la Vega M, Park SL, Seanez CM, Gokhale V, Cabello CM, Wondrak GT.

J Biol Chem. 2015 Jan 16;290(3):1623-38. doi: 10.1074/jbc.M114.592626. Epub 2014 Dec 4.


The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes.

Park SL, Justiniano R, Williams JD, Cabello CM, Qiao S, Wondrak GT.

J Invest Dermatol. 2015 Jun;135(6):1649-1658. doi: 10.1038/jid.2014.503. Epub 2014 Nov 28.


Plant extracts of the family Lauraceae: a potential resource for chemopreventive agents that activate the nuclear factor-erythroid 2-related factor 2/antioxidant response element pathway.

Shen T, Chen XM, Harder B, Long M, Wang XN, Lou HX, Wondrak GT, Ren DM, Zhang DD.

Planta Med. 2014 Mar;80(5):426-34. doi: 10.1055/s-0034-1368197. Epub 2014 Feb 28. Erratum in: Planta Med. 2014 Nov;80(7):1664.


Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue.

Williams JD, Bermudez Y, Park SL, Stratton SP, Uchida K, Hurst CA, Wondrak GT.

J Photochem Photobiol B. 2014 Mar 5;132:56-65. doi: 10.1016/j.jphotobiol.2014.01.019. Epub 2014 Feb 12.


The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV.

Tao S, Justiniano R, Zhang DD, Wondrak GT.

Redox Biol. 2013 Oct 29;1:532-41. doi: 10.1016/j.redox.2013.10.004. eCollection 2013.

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