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Items: 1 to 20 of 36


Pediatric Safety of Polysorbates in Drug Formulations.

Kriegel C, Festag M, Kishore RSK, Roethlisberger D, Schmitt G.

Children (Basel). 2019 Dec 20;7(1). pii: E1. doi: 10.3390/children7010001.


Towards the understanding of the enzymatic cleavage of polyisoprene by the dihaem-dioxygenase RoxA.

Schmitt G, Birke J, Jendrossek D.

AMB Express. 2019 Oct 17;9(1):166. doi: 10.1186/s13568-019-0888-0.


Two Different Quinohemoprotein Amine Dehydrogenases Initiate Anaerobic Degradation of Aromatic Amines in Aromatoleum aromaticum EbN1.

Schmitt G, Saft M, Arndt F, Kahnt J, Heider J.

J Bacteriol. 2019 Jul 24;201(16). pii: e00281-19. doi: 10.1128/JB.00281-19. Print 2019 Aug 15.


Characterization of an Aldehyde Oxidoreductase From the Mesophilic Bacterium Aromatoleum aromaticum EbN1, a Member of a New Subfamily of Tungsten-Containing Enzymes.

Arndt F, Schmitt G, Winiarska A, Saft M, Seubert A, Kahnt J, Heider J.

Front Microbiol. 2019 Jan 31;10:71. doi: 10.3389/fmicb.2019.00071. eCollection 2019.


An innovative investigative approach to characterize the effects observed in a combined fertility study in male and female rats.

Xie J, Funk J, Bopst M, Ottaviani G, Downes N, Hackford S, Villabruna L, Schmitt G, Barrow P.

Regul Toxicol Pharmacol. 2018 Jun;95:339-347. doi: 10.1016/j.yrtph.2018.04.007. Epub 2018 Apr 7.


Juvenile Nonclinical Safety Studies in Support of Pediatric Drug Development.

Barrow PC, Schmitt G.

Methods Mol Biol. 2017;1641:25-67. doi: 10.1007/978-1-4939-7172-5_2.


The great barrier belief: The blood-brain barrier and considerations for juvenile toxicity studies.

Schmitt G, Parrott N, Prinssen E, Barrow P.

Reprod Toxicol. 2017 Sep;72:129-135. doi: 10.1016/j.reprotox.2017.06.043. Epub 2017 Jun 13. Review.


From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.

Braendli-Baiocco A, Festag M, Dumong Erichsen K, Persson R, Mihatsch MJ, Fisker N, Funk J, Mohr S, Constien R, Ploix C, Brady K, Berrera M, Altmann B, Lenz B, Albassam M, Schmitt G, Weiser T, Schuler F, Singer T, Tessier Y.

Toxicol Sci. 2017 May 1;157(1):112-128. doi: 10.1093/toxsci/kfx025.


Erratum to: Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update.

Banholzer ML, Wandel C, Barrow P, Mannino M, Schmitt G, Guérard M, Müller L, Greig G, Amemiya K, Peck R, Singer T, Doessegger L.

Clin Transl Med. 2016 Dec;5(1):30. doi: 10.1186/s40169-016-0115-4. Epub 2016 Aug 12. No abstract available.


Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update.

Banholzer ML, Wandel C, Barrow P, Mannino M, Schmitt G, Guérard M, Müller L, Greig G, Amemiya K, Peck R, Singer T, Doessegger L.

Clin Transl Med. 2016 Dec;5(1):23. doi: 10.1186/s40169-016-0103-8. Epub 2016 Jul 25. Erratum in: Clin Transl Med. 2016 Dec;5(1):30.


Effects of GlyT1 inhibition on erythropoiesis and iron homeostasis in rats.

Winter M, Funk J, Körner A, Alberati D, Christen F, Schmitt G, Altmann B, Pospischil A, Singer T.

Exp Hematol. 2016 Oct;44(10):964-974.e4. doi: 10.1016/j.exphem.2016.07.003. Epub 2016 Jul 9.


Regulatory Approaches to Nonclinical Reproductive Toxicity Testing of Anti-Cancer Drugs.

Barrow P, Schmitt G.

Anticancer Agents Med Chem. 2017;17(9):1171-1183. doi: 10.2174/1871520616666160613122702. Review.


An unnatural death by propan-1-ol and propan-2-ol.

Skopp G, Gutmann I, Schwarz CS, Schmitt G.

Int J Legal Med. 2016 Jul;130(4):975-980. doi: 10.1007/s00414-015-1302-3. Epub 2015 Dec 28.


Functional analysis and transcriptional output of the Göttingen minipig genome.

Heckel T, Schmucki R, Berrera M, Ringshandl S, Badi L, Steiner G, Ravon M, Küng E, Kuhn B, Kratochwil NA, Schmitt G, Kiialainen A, Nowaczyk C, Daff H, Khan AP, Lekolool I, Pelle R, Okoth E, Bishop R, Daubenberger C, Ebeling M, Certa U.

BMC Genomics. 2015 Nov 14;16:932. doi: 10.1186/s12864-015-2119-7.


[Diuretics and their potential effect on breath-alcohol concentration--a case report].

Schmitt G, Skopp G.

Arch Kriminol. 2015 May-Jun;235(5-6):172-81. German.


Enzymes of anaerobic ethylbenzene and p-ethylphenol catabolism in 'Aromatoleum aromaticum': differentiation and differential induction.

Muhr E, Schühle K, Clermont L, Sünwoldt K, Kleinsorge D, Seyhan D, Kahnt J, Schall I, Cordero PR, Schmitt G, Heider J.

Arch Microbiol. 2015 Nov;197(9):1051-62. doi: 10.1007/s00203-015-1142-z. Epub 2015 Aug 15.


Safety of Excipients in Pediatric Formulations-A Call for Toxicity Studies in Juvenile Animals?

Schmitt G.

Children (Basel). 2015 May 15;2(2):191-7. doi: 10.3390/children2020191. Review.


Simultaneous involvement of a tungsten-containing aldehyde:ferredoxin oxidoreductase and a phenylacetaldehyde dehydrogenase in anaerobic phenylalanine metabolism.

Debnar-Daumler C, Seubert A, Schmitt G, Heider J.

J Bacteriol. 2014 Jan;196(2):483-92. doi: 10.1128/JB.00980-13. Epub 2013 Nov 8.


Functional identification of rubber oxygenase (RoxA) in soil and marine myxobacteria.

Birke J, Röther W, Schmitt G, Jendrossek D.

Appl Environ Microbiol. 2013 Oct;79(20):6391-9. doi: 10.1128/AEM.02194-13. Epub 2013 Aug 9.


Structure of the processive rubber oxygenase RoxA from Xanthomonas sp.

Seidel J, Schmitt G, Hoffmann M, Jendrossek D, Einsle O.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13833-8. doi: 10.1073/pnas.1305560110. Epub 2013 Aug 6.

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