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Items: 1 to 20 of 54


Optimized photo-stimulation of halorhodopsin for long-term neuronal inhibition.

Zhang C, Yang S, Flossmann T, Gao S, Witte OW, Nagel G, Holthoff K, Kirmse K.

BMC Biol. 2019 Nov 27;17(1):95. doi: 10.1186/s12915-019-0717-6.


Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation.

Neitzel C, Seiwert N, Göder A, Diehl E, Weber C, Nagel G, Stroh S, Rasenberger B, Christmann M, Fahrer J.

Cells. 2019 Jul 30;8(8). pii: E794. doi: 10.3390/cells8080794.


Human platelet lysate as validated replacement for animal serum to assess chemosensitivity.

Pons M, Nagel G, Zeyn Y, Beyer M, Laguna T, Brachetti T, Sellmer A, Mahboobi S, Conradi R, Butter F, Krämer OH.

ALTEX. 2019;36(2):277-288. doi: 10.14573/altex.1809211. Epub 2018 Dec 14.


Two-component cyclase opsins of green algae are ATP-dependent and light-inhibited guanylyl cyclases.

Tian Y, Gao S, von der Heyde EL, Hallmann A, Nagel G.

BMC Biol. 2018 Dec 6;16(1):144. doi: 10.1186/s12915-018-0613-5.


Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo.

Kraus A, McKeague M, Seiwert N, Nagel G, Geisen SM, Ziegler N, Trantakis IA, Kaina B, Thomas AD, Sturla SJ, Fahrer J.

Arch Toxicol. 2019 Feb;93(2):559-572. doi: 10.1007/s00204-018-2355-0. Epub 2018 Nov 16.


Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition.

Beck S, Yu-Strzelczyk J, Pauls D, Constantin OM, Gee CE, Ehmann N, Kittel RJ, Nagel G, Gao S.

Front Neurosci. 2018 Oct 2;12:643. doi: 10.3389/fnins.2018.00643. eCollection 2018.


Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain.

Scheib U, Broser M, Constantin OM, Yang S, Gao S, Mukherjee S, Stehfest K, Nagel G, Gee CE, Hegemann P.

Nat Commun. 2018 May 24;9(1):2046. doi: 10.1038/s41467-018-04428-w.


PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.

Dörsam B, Seiwert N, Foersch S, Stroh S, Nagel G, Begaliew D, Diehl E, Kraus A, McKeague M, Minneker V, Roukos V, Reißig S, Waisman A, Moehler M, Stier A, Mangerich A, Dantzer F, Kaina B, Fahrer J.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4061-E4070. doi: 10.1073/pnas.1712345115. Epub 2018 Apr 9.


A novel rhodopsin phosphodiesterase from Salpingoeca rosetta shows light-enhanced substrate affinity.

Tian Y, Gao S, Yang S, Nagel G.

Biochem J. 2018 Mar 26;475(6):1121-1128. doi: 10.1042/BCJ20180010.


Rhodopsin optogenetic toolbox v2.0 for light-sensitive excitation and inhibition in Caenorhabditis elegans.

Bergs A, Schultheis C, Fischer E, Tsunoda SP, Erbguth K, Husson SJ, Govorunova E, Spudich JL, Nagel G, Gottschalk A, Liewald JF.

PLoS One. 2018 Feb 1;13(2):e0191802. doi: 10.1371/journal.pone.0191802. eCollection 2018.


Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons.

Scholz N, Guan C, Nieberler M, Grotemeyer A, Maiellaro I, Gao S, Beck S, Pawlak M, Sauer M, Asan E, Rothemund S, Winkler J, Prömel S, Nagel G, Langenhan T, Kittel RJ.

Elife. 2017 Aug 8;6. pii: e28360. doi: 10.7554/eLife.28360.


Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp.

Gao S, Nagpal J, Schneider MW, Kozjak-Pavlovic V, Nagel G, Gottschalk A.

Nat Commun. 2015 Sep 8;6:8046. doi: 10.1038/ncomms9046.


Optogenetics: 10 years after ChR2 in neurons--views from the community.

Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI.

Nat Neurosci. 2015 Sep;18(9):1202-12. doi: 10.1038/nn.4106. Review. No abstract available.


DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.

Fahrer J, Frisch J, Nagel G, Kraus A, Dörsam B, Thomas AD, Reißig S, Waisman A, Kaina B.

Carcinogenesis. 2015 Oct;36(10):1235-44. doi: 10.1093/carcin/bgv114. Epub 2015 Aug 4.


Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.

Göder A, Nagel G, Kraus A, Dörsam B, Seiwert N, Kaina B, Fahrer J.

Carcinogenesis. 2015 Aug;36(8):817-31. doi: 10.1093/carcin/bgv070. Epub 2015 May 21.


Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications.

Dawydow A, Gueta R, Ljaschenko D, Ullrich S, Hermann M, Ehmann N, Gao S, Fiala A, Langenhan T, Nagel G, Kittel RJ.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13972-7. doi: 10.1073/pnas.1408269111. Epub 2014 Sep 8.


A LOV-domain-mediated blue-light-activated adenylate (adenylyl) cyclase from the cyanobacterium Microcoleus chthonoplastes PCC 7420.

Raffelberg S, Wang L, Gao S, Losi A, Gärtner W, Nagel G.

Biochem J. 2013 Nov 1;455(3):359-65. doi: 10.1042/BJ20130637.


From channelrhodopsins to optogenetics.

Hegemann P, Nagel G.

EMBO Mol Med. 2013 Feb;5(2):173-6. doi: 10.1002/emmm.201202387. Epub 2013 Jan 22. No abstract available.


Degradation of channelopsin-2 in the absence of retinal and degradation resistance in certain mutants.

Ullrich S, Gueta R, Nagel G.

Biol Chem. 2013 Feb;394(2):271-80. doi: 10.1515/hsz-2012-0256.


Optogenetic long-term manipulation of behavior and animal development.

Schultheis C, Liewald JF, Bamberg E, Nagel G, Gottschalk A.

PLoS One. 2011 Apr 20;6(4):e18766. doi: 10.1371/journal.pone.0018766.

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