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A proposed approach to accelerate evidence generation for genomic-based technologies in the context of a learning health system.

Lu CY, Williams MS, Ginsburg GS, Toh S, Brown JS, Khoury MJ.

Genet Med. 2017 Aug 10. doi: 10.1038/gim.2017.122. [Epub ahead of print] Review.


Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network.

Sperber NR, Carpenter JS, Cavallari LH, J Damschroder L, Cooper-DeHoff RM, Denny JC, Ginsburg GS, Guan Y, Horowitz CR, Levy KD, Levy MA, Madden EB, Matheny ME, Pollin TI, Pratt VM, Rosenman M, Voils CI, W Weitzel K, Wilke RA, Ryanne Wu R, Orlando LA.

BMC Med Genomics. 2017 May 22;10(1):35. doi: 10.1186/s12920-017-0273-2.


Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research.

Phillips KA, Deverka PA, Sox HC, Khoury MJ, Sandy LG, Ginsburg GS, Tunis SR, Orlando LA, Douglas MP.

Genet Med. 2017 Oct;19(10):1081-1091. doi: 10.1038/gim.2017.21. Epub 2017 Apr 13.


Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.

Wang L, Ko ER, Gilchrist JJ, Pittman KJ, Rautanen A, Pirinen M, Thompson JW, Dubois LG, Langley RJ, Jaslow SL, Salinas RE, Rouse DC, Moseley MA, Mwarumba S, Njuguna P, Mturi N; Wellcome Trust Case Control Consortium 2; Kenyan Bacteraemia Study Group, Williams TN, Scott JA, Hill AV, Woods CW, Ginsburg GS, Tsalik EL, Ko DC.

Sci Adv. 2017 Mar 8;3(3):e1602096. doi: 10.1126/sciadv.1602096. eCollection 2017 Mar.


Primary care providers' use of pharmacist support for delivery of pharmacogenetic testing.

Haga SB, Mills R, Moaddeb J, Allen LaPointe N, Cho A, Ginsburg GS.

Pharmacogenomics. 2017 Mar;18(4):359-367. doi: 10.2217/pgs-2016-0177. Epub 2017 Feb 22.


Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection.

Burke TW, Henao R, Soderblom E, Tsalik EL, Thompson JW, McClain MT, Nichols M, Nicholson BP, Veldman T, Lucas JE, Moseley MA, Turner RB, Lambkin-Williams R, Hero AO 3rd, Woods CW, Ginsburg GS.

EBioMedicine. 2017 Mar;17:172-181. doi: 10.1016/j.ebiom.2017.02.015. Epub 2017 Feb 21.


An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

Voora D, Coles A, Lee KL, Hoffmann U, Wingrove JA, Rhees B, Huang L, Daniels SE, Monane M, Rosenberg S, Shah SH, Kraus WE, Ginsburg GS, Douglas PS.

Am Heart J. 2017 Feb;184:133-140. doi: 10.1016/j.ahj.2016.11.004. Epub 2016 Nov 15.


The effective rate of influenza reassortment is limited during human infection.

Sobel Leonard A, McClain MT, Smith GJ, Wentworth DE, Halpin RA, Lin X, Ransier A, Stockwell TB, Das SR, Gilbert AS, Lambkin-Williams R, Ginsburg GS, Woods CW, Koelle K, Illingworth CJ.

PLoS Pathog. 2017 Feb 7;13(2):e1006203. doi: 10.1371/journal.ppat.1006203. eCollection 2017 Feb.


Genomics-Inspired Biomarkers and Diagnostics-Where Are They?

Ginsburg GS.

Clin Chem. 2017 Jan;63(1):255-257. doi: 10.1373/clinchem.2016.266114. Epub 2016 Nov 10. No abstract available.


Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification.

Sobel Leonard A, McClain MT, Smith GJ, Wentworth DE, Halpin RA, Lin X, Ransier A, Stockwell TB, Das SR, Gilbert AS, Lambkin-Williams R, Ginsburg GS, Woods CW, Koelle K.

J Virol. 2016 Nov 28;90(24):11247-11258. Print 2016 Dec 15.


Philanthropy for Science: Is It a Viable Option?

Ohman EM, Douglas PS, Dean LB, Ginsburg GS.

Circ Res. 2016 Oct 28;119(10):1057-1059. No abstract available.


Realizing the Full Potential of Precision Medicine in Health and Health Care.

Dzau VJ, Ginsburg GS.

JAMA. 2016 Oct 25;316(16):1659-1660. doi: 10.1001/jama.2016.14117. No abstract available.


Patient experiences with pharmacogenetic testing in a primary care setting.

Haga SB, Mills R, Moaddeb J, Allen Lapointe N, Cho A, Ginsburg GS.

Pharmacogenomics. 2016 Oct;17(15):1629-1636. Epub 2016 Sep 20.


Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer.

Voora D, Rao AK, Jalagadugula GS, Myers R, Harris E, Ortel TL, Ginsburg GS.

EBioMedicine. 2016 Sep;11:157-164. doi: 10.1016/j.ebiom.2016.08.021. Epub 2016 Aug 14.


Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes.

Wu RR, Myers RA, Hauser ER, Vorderstrasse A, Cho A, Ginsburg GS, Orlando LA.

J Genet Couns. 2017 Feb;26(1):133-140. doi: 10.1007/s10897-016-9988-z. Epub 2016 Jun 14.


Opportunities for the Cardiovascular Community in the Precision Medicine Initiative.

Shah SH, Arnett D, Houser SR, Ginsburg GS, MacRae C, Mital S, Loscalzo J, Hall JL.

Circulation. 2016 Jan 12;133(2):226-31. doi: 10.1161/CIRCULATIONAHA.115.019475.


Developing Biomarker Arrays Predicting Sleep and Circadian-Coupled Risks to Health.

Mullington JM, Abbott SM, Carroll JE, Davis CJ, Dijk DJ, Dinges DF, Gehrman PR, Ginsburg GS, Gozal D, Haack M, Lim DC, Macrea M, Pack AI, Plante DT, Teske JA, Zee PC.

Sleep. 2016 Apr 1;39(4):727-36. doi: 10.5665/sleep.5616. No abstract available.


Clinical utility of a Web-enabled risk-assessment and clinical decision support program.

Orlando LA, Wu RR, Myers RA, Buchanan AH, Henrich VC, Hauser ER, Ginsburg GS.

Genet Med. 2016 Oct;18(10):1020-8. doi: 10.1038/gim.2015.210. Epub 2016 Mar 3.


A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.

McClain MT, Nicholson BP, Park LP, Liu TY, Hero AO 3rd, Tsalik EL, Zaas AK, Veldman T, Hudson LL, Lambkin-Williams R, Gilbert A, Burke T, Nichols M, Ginsburg GS, Woods CW.

Open Forum Infect Dis. 2016 Jan 19;3(1):ofw007. doi: 10.1093/ofid/ofw007. eCollection 2016 Jan.


Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study.

Kertai MD, Ji Y, Li YJ, Mathew JP, Daubert JP, Podgoreanu MV; PEGASUS Investigative Team.

Can J Anaesth. 2016 Apr;63(4):397-410. doi: 10.1007/s12630-015-0576-8. Epub 2016 Feb 8.

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