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Tumour Biol. 2016 Jul;37(7):9951-8. doi: 10.1007/s13277-016-4869-5. Epub 2016 Jan 27.

Elevated STMN1 promotes tumor growth and invasion in endometrial carcinoma.

Author information

1
Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated International Peace Maternity and Child Health Hospital, No. 910, Henshan Road, Xujiahui District, Shanghai, 200030, China.
2
Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, No. 1, Xueshi Road, Hangzhou, Zhejiang, 310006, China.
3
Department of Gynecology, Tongji University School of Medicine Affiliated Shanghai First Maternity and Infant Hospital, No. 2669 Gaoke West Road, Pudong New Area, Shanghai, 200126, China.
4
Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People's Hospital, 650 New Songjiang Road, Shanghai, 201620, China.
5
Department of Gynecology, Tongji University School of Medicine Affiliated Shanghai First Maternity and Infant Hospital, No. 2669 Gaoke West Road, Pudong New Area, Shanghai, 200126, China. wanxiaoping@Tongji.edu.cn.

Abstract

Overexpression of stathmin (STMN1) is closely linked to tumor metastases and poor prognosis in endometrial carcinoma (EC). However, the underlying mechanism is little known. In the present study, we investigated the expression of STMN1 in EC. Subsequently, we assessed the role of STMN1 in EC cell proliferation and migration. Our data show that STMN1 is upregulated in EC, and elevated expression of STMN1 is correlated positively with tumor stage and lymph node metastasis. In vitro, forced expression of STMN1 promoted cell invasion and migration. In contrast, knockdown of STMN1 inhibited cell aggressive behaviors. Moreover, the expression and the activity changes of matrix metalloproteinases (MMP)-2/9 were observed in EC cells after the cells being silenced or overexpression of STMN1. In conclusion, STMN1 is an oncogene and it enhances the growth and invasion of EC possibly by mediating the secretion and activation of MMP2 and MMP9 protein.

KEYWORDS:

Endometrial cancer; Gelatin zymography; MMP2; MMP9; STMN1

PMID:
26815505
DOI:
10.1007/s13277-016-4869-5
[Indexed for MEDLINE]

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