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Items: 1 to 20 of 42


Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice.

Buss LA, Ang AD, Hock B, Robinson BA, Currie MJ, Dachs GU.

PLoS One. 2020 Mar 18;15(3):e0229290. doi: 10.1371/journal.pone.0229290. eCollection 2020.


Erythrocyte Ascorbate Is a Potential Indicator of Steady-State Plasma Ascorbate Concentrations in Healthy Non-Fasting Individuals.

Pullar JM, Dunham S, Dachs GU, Vissers MCM, Carr AC.

Nutrients. 2020 Feb 6;12(2). pii: E418. doi: 10.3390/nu12020418.


Effects of Exercise on the Tumour Microenvironment.

Buss LA, Dachs GU.

Adv Exp Med Biol. 2020;1225:31-51. doi: 10.1007/978-3-030-35727-6_3. Review.


Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells.

Wohlrab C, Kuiper C, Vissers MC, Phillips E, Robinson BA, Dachs GU.

Hypoxia (Auckl). 2019 May 15;7:17-31. doi: 10.2147/HP.S201643. eCollection 2019.


Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels.

Campbell EJ, Dachs GU, Morrin HR, Davey VC, Robinson BA, Vissers MCM.

BMC Cancer. 2019 Apr 3;19(1):307. doi: 10.1186/s12885-019-5503-x.


The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein.

Wohlrab C, Vissers MCM, Phillips E, Morrin H, Robinson BA, Dachs GU.

Front Oncol. 2018 Nov 30;8:574. doi: 10.3389/fonc.2018.00574. eCollection 2018.


Characterisation of a Mouse Model of Breast Cancer with Metabolic Syndrome.

Buss LA, Mandani A, Phillips E, Scott NJA, Currie MJ, Dachs GU.

In Vivo. 2018 Sep-Oct;32(5):1071-1080. doi: 10.21873/invivo.11348.


The Role of Exercise and Hyperlipidaemia in Breast Cancer Progression.

Buss LA, Dachs GU.

Exerc Immunol Rev. 2018;24:10-25. Review.


Voluntary exercise slows breast tumor establishment and reduces tumor hypoxia in ApoE-/- mice.

Buss LA, Dachs GU.

J Appl Physiol (1985). 2018 Apr 1;124(4):938-949. doi: 10.1152/japplphysiol.00738.2017. Epub 2017 Dec 14.


Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge.

Wohlrab C, Phillips E, Dachs GU.

Front Oncol. 2017 Apr 24;7:74. doi: 10.3389/fonc.2017.00074. eCollection 2017. Review.


Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo-/- mice.

Campbell EJ, Vissers MC, Dachs GU.

Hypoxia (Auckl). 2016 Apr 8;4:41-52. eCollection 2016.


Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice.

Campbell EJ, Vissers MCM, Wohlrab C, Hicks KO, Strother RM, Bozonet SM, Robinson BA, Dachs GU.

Free Radic Biol Med. 2016 Oct;99:451-462. doi: 10.1016/j.freeradbiomed.2016.08.027. Epub 2016 Aug 24.


Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo(-/-) mice.

Campbell EJ, Vissers MC, Bozonet S, Dyer A, Robinson BA, Dachs GU.

Cancer Med. 2015 Feb;4(2):303-14. doi: 10.1002/cam4.349. Epub 2014 Oct 30.


Current limitations of murine models in oncology for ascorbate research.

Campbell EJ, Dachs GU.

Front Oncol. 2014 Oct 14;4:282. doi: 10.3389/fonc.2014.00282. eCollection 2014. Review.


Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5.

Wang J, Guise CP, Dachs GU, Phung Y, Hsu AH, Lambie NK, Patterson AV, Wilson WR.

Biochem Pharmacol. 2014 Oct 15;91(4):436-46. doi: 10.1016/j.bcp.2014.08.003. Epub 2014 Aug 15.


Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics.

Kanthou C, Dachs GU, Lefley DV, Steele AJ, Coralli-Foxon C, Harris S, Greco O, Dos Santos SA, Reyes-Aldasoro CC, English WR, Tozer GM.

PLoS One. 2014 Aug 13;9(8):e104015. doi: 10.1371/journal.pone.0104015. eCollection 2014.


Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer.

Vissers MC, Kuiper C, Dachs GU.

Biochem Soc Trans. 2014 Aug;42(4):945-51. doi: 10.1042/BST20140118. Review.


Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1.

Flett T, Campbell EJ, Phillips E, Vissers MCM, Dachs GU.

Biomedicines. 2014 Mar 5;2(1):98-109. doi: 10.3390/biomedicines2010098.


Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer.

Kuiper C, Dachs GU, Munn D, Currie MJ, Robinson BA, Pearson JF, Vissers MC.

Front Oncol. 2014 Feb 4;4:10. doi: 10.3389/fonc.2014.00010. eCollection 2014.


Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response.

Kuiper C, Dachs GU, Currie MJ, Vissers MC.

Free Radic Biol Med. 2014 Apr;69:308-17. doi: 10.1016/j.freeradbiomed.2014.01.033. Epub 2014 Feb 2.


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