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Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management.

Senese NB, Kandasamy R, Kochan KE, Traynor JR.

Front Mol Neurosci. 2020 Jan 24;13:5. doi: 10.3389/fnmol.2020.00005. eCollection 2020. Review.


Morphine modulates the expression of mu-opioid receptor exon 5-associated full-length C-terminal splice variants by upregulating miR-378a-3p.

Lu Z, Xu J, Wang Q, Pan YX.

FASEB J. 2020 Jan 30. doi: 10.1096/fj.201901879RR. [Epub ahead of print]


Activation of the G Protein-Coupled Estrogen Receptor Elicits Store Calcium Release and Phosphorylation of the Mu-Opioid Receptors in the Human Neuroblastoma SH-SY5Y Cells.

Ding X, Gao T, Gao P, Meng Y, Zheng Y, Dong L, Luo P, Zhang G, Shi X, Rong W.

Front Neurosci. 2019 Dec 17;13:1351. doi: 10.3389/fnins.2019.01351. eCollection 2019.


Inter-country variability over time in the mortality of mechanically ventilated patients.

Peñuelas O, Muriel A, Abraira V, Frutos-Vivar F, Mancebo J, Raymondos K, Du B, Thille AW, Ríos F, González M, Del-Sorbo L, Ferguson ND, Del Carmen Marín M, Pinheiro BV, Soares MA, Nin N, Maggiore SM, Bersten A, Amin P, Cakar N, Suh GY, Abroug F, Jibaja M, Matamis D, Zeggwagh AA, Sutherasan Y, Anzueto A, Esteban A.

Intensive Care Med. 2020 Jan 7. doi: 10.1007/s00134-019-05867-9. [Epub ahead of print]


Induction of innate immune response in whiteleg shrimp (Litopenaeus vannamei) embryos.

Alvarez-Lee A, Martínez-Díaz SF, Gutiérrez-Rivera JN, Lanz-Mendoza H.

Dev Comp Immunol. 2020 Apr;105:103577. doi: 10.1016/j.dci.2019.103577. Epub 2019 Dec 15.


Modulation of sensitization processes in the management of pain and the importance of descending pathways: a role for tapentadol?

Caraci F, Coluzzi F, Marinangeli F, Mercadante S, Rinonapoli G, Romualdi P, Nicora M, Dickenson AH.

Curr Med Res Opin. 2019 Dec 11:1. doi: 10.1080/03007995.2019.1703664. [Epub ahead of print] Retraction in: Curr Med Res Opin. 2020 Jan 29;:1.


Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics.

Grim TW, Acevedo-Canabal A, Bohn LM.

Biol Psychiatry. 2020 Jan 1;87(1):15-21. doi: 10.1016/j.biopsych.2019.10.020. Epub 2019 Oct 31. Review.


Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways.

Chiricosta L, Silvestro S, Pizzicannella J, Diomede F, Bramanti P, Trubiani O, Mazzon E.

Int J Mol Sci. 2019 Nov 30;20(23). pii: E6039. doi: 10.3390/ijms20236039.


Differences in antinociceptive signalling mechanisms following morphine and fentanyl microinjections into the rat periaqueductal gray.

Morgan MM, Tran A, Wescom RL, Bobeck EN.

Eur J Pain. 2020 Mar;24(3):617-624. doi: 10.1002/ejp.1513. Epub 2019 Dec 17.


Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors.

Gandini MA, Souza IA, Raval D, Xu J, Pan YX, Zamponi GW.

Mol Brain. 2019 Nov 27;12(1):98. doi: 10.1186/s13041-019-0524-6.


Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon.

DiCello JJ, Carbone SE, Saito A, Rajasekhar P, Ceredig RA, Pham V, Valant C, Christopoulos A, Veldhuis NA, Canals M, Massotte D, Poole DP.

Cell Mol Gastroenterol Hepatol. 2019 Nov 20. pii: S2352-345X(19)30161-4. doi: 10.1016/j.jcmgh.2019.11.006. [Epub ahead of print]


Comprehensive Analysis of the Copper Exchange Implemented in Ammonia and Protonated Forms of Mordenite Using Microwave and Conventional Methods.

Shelyapina MG, Krylova EA, Zhukov YM, Zvereva IA, Rodriguez-Iznaga I, Petranovskii V, Fuentes-Moyado S.

Molecules. 2019 Nov 20;24(23). pii: E4216. doi: 10.3390/molecules24234216.


Discovery of Biased Mu-Opioid Receptor Agonists for the Treatment of Pain.

Ma M, Li X, Tong K, Cheng J, Yu Z, Ren F, Zhong B, Shi W.

ChemMedChem. 2020 Jan 7;15(1):155-161. doi: 10.1002/cmdc.201900575. Epub 2019 Nov 26.


Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening.

Poli G, Dimmito MP, Mollica A, Zengin G, Benyhe S, Zador F, Stefanucci A.

Molecules. 2019 Oct 27;24(21). pii: E3872. doi: 10.3390/molecules24213872.


A hominid-specific shift in cerebellar expression, upstream retrotransposons, and a potential cis-regulatory mechanism: bioinformatics analyses of the mu-opioid receptor gene.

Levran O, Even-Tov E, Zhao L.

Heredity (Edinb). 2020 Feb;124(2):325-335. doi: 10.1038/s41437-019-0282-3. Epub 2019 Nov 11.


Vector Competence of Italian Populations of Culicoides for Some Bluetongue Virus Strains Responsible for Recent Northern African and European Outbreaks.

Federici V, Goffredo M, Mancini G, Quaglia M, Santilli A, Di Nicola F, De Ascentis M, Cabras P, Volpicelli C, De Liberato C, Satta G, Federico G, Leone A, Pisciella M, Portanti O, Pizzurro F, Teodori L, Savini G.

Viruses. 2019 Oct 12;11(10). pii: E941. doi: 10.3390/v11100941.


Three dimensional Pt island-on-Au architectures coupled with graphite carbon nitride nanosheets for effective photo-accelerated methanol electro-oxidation.

Wang X, Sun M, Guo Y, Hu J, Zhu M.

J Colloid Interface Sci. 2020 Jan 15;558:38-46. doi: 10.1016/j.jcis.2019.09.085. Epub 2019 Sep 24.


An Experimental Study on Spinal Cord µ-Opioid and α2-Adrenergic Receptors mRNA Expression Following Stress-Induced Hyperalgesia in Male Rats.

Hormozi A, Zarifkar A, Rostami B, Naghibalhossaini F.

Iran J Med Sci. 2019 Sep;44(5):397-405. doi: 10.30476/ijms.2019.44958.


Homologous Regulation of Mu Opioid Receptor Recycling by G βγ , Protein Kinase C, and Receptor Phosphorylation.

Kunselman JM, Zajac AS, Weinberg ZY, Puthenveedu MA.

Mol Pharmacol. 2019 Dec;96(6):702-710. doi: 10.1124/mol.119.117267. Epub 2019 Oct 1.


Progress in the development of more effective and safer analgesics for pain management.

Turnaturi R, Chiechio S, Salerno L, Rescifina A, Pittalà V, Cantarella G, Tomarchio E, Parenti C, Pasquinucci L.

Eur J Med Chem. 2019 Dec 1;183:111701. doi: 10.1016/j.ejmech.2019.111701. Epub 2019 Sep 16. Review.


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