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Items: 20


Aspirin metabolites 2,3‑DHBA and 2,5‑DHBA inhibit cancer cell growth: Implications in colorectal cancer prevention.

Sankaranarayanan R, Valiveti CK, Dachineni R, Kumar DR, Lick T, Bhat GJ.

Mol Med Rep. 2020 Jan;21(1):20-34. doi: 10.3892/mmr.2019.10822. Epub 2019 Nov 18.


The Flavonoid Metabolite 2,4,6-Trihydroxybenzoic Acid Is a CDK Inhibitor and an Anti-Proliferative Agent: A Potential Role in Cancer Prevention.

Sankaranarayanan R, Valiveti CK, Kumar DR, Van Slambrouck S, Kesharwani SS, Seefeldt T, Scaria J, Tummala H, Bhat GJ.

Cancers (Basel). 2019 Mar 26;11(3). pii: E427. doi: 10.3390/cancers11030427.


Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer.

Dachineni R, Kumar DR, Callegari E, Kesharwani SS, Sankaranarayanan R, Seefeldt T, Tummala H, Bhat GJ.

Int J Oncol. 2017 Dec;51(6):1661-1673. doi: 10.3892/ijo.2017.4167. Epub 2017 Oct 19.


In Vitro and In Vivo Tumor Growth Inhibition by Glutathione Disulfide Liposomes.

Sadhu SS, Wang S, Dachineni R, Averineni RK, Yang Y, Yin H, Bhat GJ, Guan X.

Cancer Growth Metastasis. 2017 Mar 10;10:1179064417696070. doi: 10.1177/1179064417696070. eCollection 2017.


In Vitro and In Vivo Antimetastatic Effect of Glutathione Disulfide Liposomes.

Sadhu SS, Wang S, Dachineni R, Averineni RK, Seefeldt T, Xie J, Tummala H, Bhat GJ, Guan X.

Cancer Growth Metastasis. 2017 Mar 8;10:1179064417695255. doi: 10.1177/1179064417695255. eCollection 2017.


Aspirin inhibits glucose‑6‑phosphate dehydrogenase activity in HCT 116 cells through acetylation: Identification of aspirin-acetylated sites.

Ai G, Dachineni R, Kumar DR, Alfonso LF, Marimuthu S, Bhat GJ.

Mol Med Rep. 2016 Aug;14(2):1726-32. doi: 10.3892/mmr.2016.5449. Epub 2016 Jun 27.


Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic Acid: A Potential Role in Cancer Prevention.

Dachineni R, Ai G, Kumar DR, Sadhu SS, Tummala H, Bhat GJ.

Mol Cancer Res. 2016 Mar;14(3):241-52. doi: 10.1158/1541-7786.MCR-15-0360. Epub 2015 Dec 18.


Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53.

Ai G, Dachineni R, Kumar DR, Marimuthu S, Alfonso LF, Bhat GJ.

Tumour Biol. 2016 May;37(5):6007-16. doi: 10.1007/s13277-015-4438-3. Epub 2015 Nov 23.


Molecular complexation of curcumin with pH sensitive cationic copolymer enhances the aqueous solubility, stability and bioavailability of curcumin.

Kumar S, Kesharwani SS, Mathur H, Tyagi M, Bhat GJ, Tummala H.

Eur J Pharm Sci. 2016 Jan 20;82:86-96. doi: 10.1016/j.ejps.2015.11.010. Epub 2015 Nov 15.


Aspirin and salicylic acid decrease c-Myc expression in cancer cells: a potential role in chemoprevention.

Ai G, Dachineni R, Muley P, Tummala H, Bhat GJ.

Tumour Biol. 2016 Feb;37(2):1727-38. doi: 10.1007/s13277-015-3959-0. Epub 2015 Aug 28.


Efficacy of acetylsalicylic acid (aspirin) in skin B16-F0 melanoma tumor-bearing C57BL/6 mice.

Vad NM, Kudugunti SK, Wang H, Bhat GJ, Moridani MY.

Tumour Biol. 2014 May;35(5):4967-76. doi: 10.1007/s13277-014-1654-1. Epub 2014 Feb 4.


Aspirin acetylates multiple cellular proteins in HCT-116 colon cancer cells: Identification of novel targets.

Marimuthu S, Chivukula RS, Alfonso LF, Moridani M, Hagen FK, Bhat GJ.

Int J Oncol. 2011 Nov;39(5):1273-83. doi: 10.3892/ijo.2011.1113. Epub 2011 Jul 4.


Cys-141 glutathionylation of human p53: Studies using specific polyclonal antibodies in cancer samples and cell lines.

Yusuf MA, Chuang T, Bhat GJ, Srivenugopal KS.

Free Radic Biol Med. 2010 Sep 1;49(5):908-17. doi: 10.1016/j.freeradbiomed.2010.06.020. Epub 2010 Jun 25.


Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells.

Alfonso LF, Srivenugopal KS, Arumugam TV, Abbruscato TJ, Weidanz JA, Bhat GJ.

Int J Oncol. 2009 Mar;34(3):597-608.


A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation.

Vemula S, Roder KE, Yang T, Bhat GJ, Thekkumkara TJ, Abbruscato TJ.

J Pharmacol Exp Ther. 2009 Feb;328(2):487-95. doi: 10.1124/jpet.108.146589. Epub 2008 Nov 3.


Angiotensin II induces phosphorylation of glucose-regulated protein-75 in WB rat liver cells.

Krishna SB, Alfonso LF, Thekkumkara TJ, Abbruscato TJ, Bhat GJ.

Arch Biochem Biophys. 2007 Jan 1;457(1):16-28. Epub 2006 Nov 2.


Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.

Niture SK, Velu CS, Smith QR, Bhat GJ, Srivenugopal KS.

Carcinogenesis. 2007 Feb;28(2):378-89. Epub 2006 Aug 31.


Acute effect of high glucose on long-term cell growth: a role for transient glucose increase in proximal tubule cell injury.

Samikkannu T, Thomas JJ, Bhat GJ, Wittman V, Thekkumkara TJ.

Am J Physiol Renal Physiol. 2006 Jul;291(1):F162-75. Epub 2006 Feb 7.


Protein kinase C family members as a target for regulation of blood-brain barrier Na,K,2Cl-cotransporter during in vitro stroke conditions and nicotine exposure.

Yang T, Roder KE, Bhat GJ, Thekkumkara TJ, Abbruscato TJ.

Pharm Res. 2006 Feb;23(2):291-302. Epub 2006 Feb 7.


alpha-thrombin rapidly induces tyrosine phosphorylation of a novel, 74-78-kDa stress response protein(s) in lung fibroblast cells.

Bhat GJ, Samikkannu T, Thomas JJ, Thekkumkara TJ.

J Biol Chem. 2004 Nov 19;279(47):48915-22. Epub 2004 Sep 13.

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