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Items: 1 to 20 of 135

1.

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.

Martínez-García JJ, Martínez-Banaclocha H, Angosto-Bazarra D, de Torre-Minguela C, Baroja-Mazo A, Alarcón-Vila C, Martínez-Alarcón L, Amores-Iniesta J, Martín-Sánchez F, Ercole GA, Martínez CM, González-Lisorge A, Fernández-Pacheco J, Martínez-Gil P, Adriouch S, Koch-Nolte F, Luján J, Acosta-Villegas F, Parrilla P, García-Palenciano C, Pelegrin P.

Nat Commun. 2019 Jun 20;10(1):2711. doi: 10.1038/s41467-019-10626-x.

2.

P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP.

Johnsen B, Kaschubowski KE, Nader S, Schneider E, Nicola JA, Fliegert R, Wolf IMA, Guse AH, Nikolaev VO, Koch-Nolte F, Haag F.

Purinergic Signal. 2019 Jun;15(2):155-166. doi: 10.1007/s11302-019-09654-5. Epub 2019 Apr 23.

PMID:
31016551
3.

Novel biologics targeting the P2X7 ion channel.

Koch-Nolte F, Eichhoff A, Pinto-Espinoza C, Schwarz N, Schäfer T, Menzel S, Haag F, Demeules M, Gondé H, Adriouch S.

Curr Opin Pharmacol. 2019 Apr 12;47:110-118. doi: 10.1016/j.coph.2019.03.001. [Epub ahead of print] Review.

PMID:
30986625
4.

Nanobody Targeting of Epidermal Growth Factor Receptor (EGFR) Ectodomain Variants Overcomes Resistance to Therapeutic EGFR Antibodies.

Tintelnot J, Baum N, Schultheiß C, Braig F, Trentmann M, Finter J, Fumey W, Bannas P, Fehse B, Riecken K, Schuetze K, Bokemeyer C, Rösner T, Valerius T, Peipp M, Koch-Nolte F, Binder M.

Mol Cancer Ther. 2019 Apr;18(4):823-833. doi: 10.1158/1535-7163.MCT-18-0849. Epub 2019 Mar 1.

PMID:
30824613
5.

Purine Release, Metabolism, and Signaling in the Inflammatory Response.

Linden J, Koch-Nolte F, Dahl G.

Annu Rev Immunol. 2019 Apr 26;37:325-347. doi: 10.1146/annurev-immunol-051116-052406. Epub 2019 Jan 24.

PMID:
30676821
6.

Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation.

Fliegert R, Heeren J, Koch-Nolte F, Nikolaev VO, Lohr C, Meier C, Guse AH.

Biochem Soc Trans. 2019 Feb 28;47(1):329-337. doi: 10.1042/BST20180419. Epub 2019 Jan 23. Review.

PMID:
30674608
7.

T RM maintenance is regulated by tissue damage via P2RX7.

Stark R, Wesselink TH, Behr FM, Kragten NAM, Arens R, Koch-Nolte F, van Gisbergen KPJM, van Lier RAW.

Sci Immunol. 2018 Dec 14;3(30). pii: eaau1022. doi: 10.1126/sciimmunol.aau1022.

PMID:
30552101
8.

CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.

Schütze K, Petry K, Hambach J, Schuster N, Fumey W, Schriewer L, Röckendorf J, Menzel S, Albrecht B, Haag F, Stortelers C, Bannas P, Koch-Nolte F.

Front Immunol. 2018 Nov 19;9:2553. doi: 10.3389/fimmu.2018.02553. eCollection 2018.

9.

Perspectives for the Development of CD38-Specific Heavy Chain Antibodies as Therapeutics for Multiple Myeloma.

Bannas P, Koch-Nolte F.

Front Immunol. 2018 Nov 6;9:2559. doi: 10.3389/fimmu.2018.02559. eCollection 2018. Review.

10.

Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity.

Schmiesing J, Storch S, Dörfler AC, Schweizer M, Makrypidi-Fraune G, Thelen M, Sylvester M, Gieselmann V, Meyer-Schwesinger C, Koch-Nolte F, Tidow H, Mühlhausen C, Waheed A, Sly WS, Braulke T.

Cell Rep. 2018 Sep 11;24(11):2946-2956. doi: 10.1016/j.celrep.2018.08.014.

11.

Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme.

Leutert M, Menzel S, Braren R, Rissiek B, Hopp AK, Nowak K, Bisceglie L, Gehrig P, Li H, Zolkiewska A, Koch-Nolte F, Hottiger MO.

Cell Rep. 2018 Aug 14;24(7):1916-1929.e5. doi: 10.1016/j.celrep.2018.07.048.

12.

Monitoring the Sensitivity of T Cell Populations Towards NAD+ Released During Cell Preparation.

Rissiek B, Lukowiak M, Haag F, Magnus T, Koch-Nolte F.

Methods Mol Biol. 2018;1813:317-326. doi: 10.1007/978-1-4939-8588-3_22.

PMID:
30097878
13.

Monitoring Expression and Enzyme Activity of Ecto-ARTCs.

Menzel S, Adriouch S, Bannas P, Haag F, Koch-Nolte F.

Methods Mol Biol. 2018;1813:167-186. doi: 10.1007/978-1-4939-8588-3_11.

PMID:
30097867
14.

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.

Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V, Nicke A.

Elife. 2018 Aug 3;7. pii: e36217. doi: 10.7554/eLife.36217.

15.

In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells.

Rissiek B, Lukowiak M, Raczkowski F, Magnus T, Mittrücker HW, Koch-Nolte F.

Front Immunol. 2018 Jul 9;9:1580. doi: 10.3389/fimmu.2018.01580. eCollection 2018.

16.

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis.

Zabala A, Vazquez-Villoldo N, Rissiek B, Gejo J, Martin A, Palomino A, Perez-Samartín A, Pulagam KR, Lukowiak M, Capetillo-Zarate E, Llop J, Magnus T, Koch-Nolte F, Rassendren F, Matute C, Domercq M.

EMBO Mol Med. 2018 Aug;10(8). pii: e8743. doi: 10.15252/emmm.201708743.

17.

CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes.

Raczkowski F, Rissiek A, Ricklefs I, Heiss K, Schumacher V, Wundenberg K, Haag F, Koch-Nolte F, Tolosa E, Mittrücker HW.

PLoS One. 2018 May 9;13(5):e0197151. doi: 10.1371/journal.pone.0197151. eCollection 2018.

18.

Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity.

Menzel S, Schwarz N, Haag F, Koch-Nolte F.

Front Pharmacol. 2018 Mar 27;9:266. doi: 10.3389/fphar.2018.00266. eCollection 2018. Review.

19.

Modulating ion channel function with antibodies and nanobodies.

Stortelers C, Pinto-Espinoza C, Van Hoorick D, Koch-Nolte F.

Curr Opin Immunol. 2018 Jun;52:18-26. doi: 10.1016/j.coi.2018.02.003. Epub 2018 Mar 23. Review.

PMID:
29579624
20.

The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NM.

J Am Soc Nephrol. 2018 May;29(5):1536-1548. doi: 10.1681/ASN.2017070805. Epub 2018 Mar 19.

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