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Items: 1 to 20 of 54

1.

Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay.

Holzer M, Schade N, Opitz A, Hilbrich I, Stieler J, Vogel T, Neukel V, Oberstadt M, Totzke F, Schächtele C, Sippl W, Hilgeroth A.

Molecules. 2018 Sep 12;23(9). pii: E2335. doi: 10.3390/molecules23092335.

2.

Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge Stylissa carteri.

Hamed ANE, Schmitz R, Bergermann A, Totzke F, Kubbutat M, Müller WEG, Youssef DTA, Bishr MM, Kamel MS, Edrada-Ebel R, Wätjen W, Proksch P.

Z Naturforsch C. 2018 Apr 25;73(5-6):199-210. doi: 10.1515/znc-2017-0161.

PMID:
29353267
3.

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance.

Fischer T, Najjar K, Totzke F, Schächtele C, Sippl W, Ritter C, Hilgeroth A.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1-8. doi: 10.1080/14756366.2017.1370583.

4.

Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors.

Fischer T, Krüger T, Najjar A, Totzke F, Schächtele C, Sippl W, Ritter C, Hilgeroth A.

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2708-2712. doi: 10.1016/j.bmcl.2017.04.053. Epub 2017 Apr 19.

PMID:
28478927
5.

Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors.

Schlütke L, Immer M, Preu L, Totzke F, Schächtele C, Kubbutat MHG, Kunick C.

Eur J Pharm Biopharm. 2018 May;126:89-94. doi: 10.1016/j.ejpb.2017.03.011. Epub 2017 Mar 15.

PMID:
28315448
6.

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R.

Hempel C, Totzke F, Schächtele C, Najjar A, Sippl W, Ritter C, Hilgeroth A.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):271-276. doi: 10.1080/14756366.2016.1247062.

7.

Cytotoxic effects of the anthraquinone derivatives 1'-deoxyrhodoptilometrin and (S)-(-)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp.

Wätjen W, Ebada SS, Bergermann A, Chovolou Y, Totzke F, Kubbutat MHG, Lin W, Proksch P.

Arch Toxicol. 2017 Mar;91(3):1485-1495. doi: 10.1007/s00204-016-1787-7. Epub 2016 Jul 29.

PMID:
27473261
8.

Drug Development of Small-Molecule Inhibitors of AD-Relevant Kinases as Novel Perspective Multitargeted Approach.

Tell V, Hilbrich I, Holzer M, Totzke F, Schachtele C, Slynko I, Sippl W, Hilgeroth A.

Curr Alzheimer Res. 2016;13(12):1330-1336. Review.

PMID:
27306698
9.

Cell lines expressing recombinant transmembrane domain-activated receptor kinases as tools for drug discovery.

Weber H, Müller D, Müller M, Ortiz A, Birkle M, Umber S, Ketterer C, Siedentopf O, Feger D, Totzke F, Kubbutat M, Schaechtele C, Ballmer-Hofer K, Ehlert JE, Graeser R.

J Biomol Screen. 2014 Dec;19(10):1350-61. doi: 10.1177/1087057114552414. Epub 2014 Sep 26.

PMID:
25260782
10.

Optimization of potent DFG-in inhibitors of platelet derived growth factor receptorβ (PDGF-Rβ) guided by water thermodynamics.

Horbert R, Pinchuk B, Johannes E, Schlosser J, Schmidt D, Cappel D, Totzke F, Schächtele C, Peifer C.

J Med Chem. 2015 Jan 8;58(1):170-82. doi: 10.1021/jm500373x. Epub 2014 Jul 21.

PMID:
25007344
11.

Development of first lead structures for phosphoinositide 3-kinase-C2γ inhibitors.

Freitag A, Prajwal P, Shymanets A, Harteneck C, Nürnberg B, Schächtele C, Kubbutat M, Totzke F, Laufer SA.

J Med Chem. 2015 Jan 8;58(1):212-21. doi: 10.1021/jm5006034. Epub 2014 Jul 14.

PMID:
24983663
12.

Discovery of 4-anilino α-carbolines as novel Brk inhibitors.

Mahmoud KA, Krug M, Wersig T, Slynko I, Schächtele C, Totzke F, Sippl W, Hilgeroth A.

Bioorg Med Chem Lett. 2014 Apr 15;24(8):1948-51. doi: 10.1016/j.bmcl.2014.03.002. Epub 2014 Mar 12.

PMID:
24650640
13.

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors.

Barbosa ML, Lima LM, Tesch R, Sant'Anna CM, Totzke F, Kubbutat MH, Schächtele C, Laufer SA, Barreiro EJ.

Eur J Med Chem. 2014 Jan;71:1-14. doi: 10.1016/j.ejmech.2013.10.058. Epub 2013 Oct 31.

PMID:
24269511
14.

Marine derived hamacanthins as lead for the development of novel PDGFRβ protein kinase inhibitors.

Pinchuk B, Johannes E, Gul S, Schlosser J, Schaechtele C, Totzke F, Peifer C.

Mar Drugs. 2013 Aug 26;11(9):3209-23. doi: 10.3390/md11093209.

15.

Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells.

Limper C, Wang Y, Ruhl S, Wang Z, Lou Y, Totzke F, Kubbutat MH, Chovolou Y, Proksch P, Wätjen W.

J Pharm Pharmacol. 2013 Sep;65(9):1393-408. doi: 10.1111/jphp.12107. Epub 2013 Jul 31.

PMID:
23927478
17.

Assessing the target differentiation potential of imidazole-based protein kinase inhibitors.

Dimova D, Iyer P, Vogt M, Totzke F, Kubbutat MH, Schächtele C, Laufer S, Bajorath J.

J Med Chem. 2012 Dec 27;55(24):11067-71. doi: 10.1021/jm3014508. Epub 2012 Dec 11.

PMID:
23210446
18.

Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.

Tell V, Holzer M, Herrmann L, Mahmoud KA, Schächtele C, Totzke F, Hilgeroth A.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. doi: 10.1016/j.bmcl.2012.09.006. Epub 2012 Sep 13.

PMID:
23039927
19.

Novel indeno[1,2-b]indoloquinones as inhibitors of the human protein kinase CK2 with antiproliferative activity towards a broad panel of cancer cell lines.

Hundsdörfer C, Hemmerling HJ, Hamberger J, Le Borgne M, Bednarski P, Götz C, Totzke F, Jose J.

Biochem Biophys Res Commun. 2012 Jul 20;424(1):71-5. doi: 10.1016/j.bbrc.2012.06.068. Epub 2012 Jun 21.

PMID:
22728884
20.

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.

Determann R, Dreher J, Baumann K, Preu L, Jones PG, Totzke F, Schächtele C, Kubbutat MH, Kunick C.

Eur J Med Chem. 2012 Jul;53:254-63. doi: 10.1016/j.ejmech.2012.04.007. Epub 2012 Apr 14.

PMID:
22560627

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