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Items: 1 to 20 of 51

1.

Radiosynthesis and Preclinical Evaluation of an α2A-Adrenoceptor Tracer Candidate, 6-[18F]Fluoro-marsanidine.

Krzyczmonik A, Keller T, López-Picón FR, Forsback S, Kirjavainen AK, Takkinen JS, Wasilewska A, Scheinin M, Haaparanta-Solin M, Sączewski F, Solin O.

Mol Imaging Biol. 2019 Feb 1. doi: 10.1007/s11307-019-01317-6. [Epub ahead of print]

PMID:
30710261
2.

Hybrid Molecules Composed of 2,4-Diamino-1,3,5-triazines and 2-Imino-Coumarins and Coumarins. Synthesis and Cytotoxic Properties.

Makowska A, Sączewski F, Bednarski PJ, Sączewski J, Balewski Ł.

Molecules. 2018 Jul 3;23(7). pii: E1616. doi: 10.3390/molecules23071616.

3.

Synthesis, Structure, Chemical Stability, and In Vitro Cytotoxic Properties of Novel Quinoline-3-Carbaldehyde Hydrazones Bearing a 1,2,4-Triazole or Benzotriazole Moiety.

Korcz M, Sączewski F, Bednarski PJ, Kornicka A.

Molecules. 2018 Jun 20;23(6). pii: E1497. doi: 10.3390/molecules23061497.

4.

COMPARISON OF THE EFFECTS OF MARSANIDINE DERIVATIVES ON RAT CARDIOVASCULAR SYSTEM.

Boblewski K, Lehmann A, Marchwinska A, Kornicka A, Wasilewska A, Saczewski F, Rybczynska A.

Acta Pol Pharm. 2017 Mar;74(2):579-586.

5.

Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine?

Raczak-Gutknecht J, Frąckowiak T, Nasal A, Kornicka A, Sączewski F, Kaliszan R.

Dose Response. 2017 Apr 18;15(2):1559325817701213. doi: 10.1177/1559325817701213. eCollection 2017 Apr-Jun.

6.

Comparative pharmacodynamic analysis of imidazoline compounds using rat model of ocular mydriasis with a test of quantitative structure-activity relationships.

Raczak-Gutknecht J, Nasal A, Frąckowiak T, Kornicka A, Sączewski F, Wawrzyniak R, Kubik Ł, Kaliszan R.

J Pharm Biomed Anal. 2017 Sep 10;144:122-128. doi: 10.1016/j.jpba.2017.03.053. Epub 2017 Apr 6.

PMID:
28420580
7.

Synthesis and Preliminary Cytotoxicity Studies of 1-[1-(4,5-Dihydrooxazol- 2-yl)-1H-indazol-3-yl]-3-phenylurea and 3-phenylthiourea Derivatives.

Kornicka A, Saczewski F, Bednarski PJ, Korcz M, Szumlas P, Romejko E, Sakowicz A, Sitek L, Wojciechowska M.

Med Chem. 2017;13(7):616-624. doi: 10.2174/1573406413666170306114401.

PMID:
28266278
8.

1-[(Imidazolidin-2-yl)imino]-1H-indoles as new hypotensive agents: synthesis and in vitro and in vivo biological studies.

Kornicka A, Wasilewska A, Sączewski J, Hudson AL, Boblewski K, Lehmann A, Gzella K, Belka M, Sączewski F, Gdaniec M, Rybczyńska A, Bączek T.

Chem Biol Drug Des. 2017 Mar;89(3):400-410. doi: 10.1111/cbdd.12846. Epub 2016 Sep 26.

PMID:
27566285
9.

Imidazoline scaffold in medicinal chemistry: a patent review (2012-2015).

Sączewski F, Kornicka A, Balewski Ł.

Expert Opin Ther Pat. 2016 Sep;26(9):1031-48. doi: 10.1080/13543776.2016.1210128. Epub 2016 Jul 20. Review. Erratum in: Expert Opin Ther Pat. 2017 Feb;27(2):227.

PMID:
27382975
10.

Circulatory effect of TCS-80, a new imidazoline compound, in rats.

Boblewski K, Lehmann A, Sączewski F, Sączewski J, Kornicka A, Marchwińska A, Rybczyńska A.

Pharmacol Rep. 2016 Aug;68(4):715-9. doi: 10.1016/j.pharep.2016.03.008. Epub 2016 Mar 23.

PMID:
27127910
11.

Transfer of SAR information from hypotensive indazole to indole derivatives acting at α-adrenergic receptors: In vitro and in vivo studies.

Sączewski J, Hudson A, Scheinin M, Wasilewska A, Sączewski F, Rybczyńska A, Ferdousi M, Laurila JM, Boblewski K, Lehmann A, Watts H, Ma D.

Eur J Med Chem. 2016 Jun 10;115:406-15. doi: 10.1016/j.ejmech.2016.03.026. Epub 2016 Mar 14.

PMID:
27031216
12.

The effect of 7-fluoro-marsanidine, a novel α2-adrenoceptor agonist, on extracellular noradrenaline in rat frontal cortex: a microdialysis study.

Ferdousi M, Lalies M, Wasilewska A, Sączewski F, Hudson A.

Neurosci Lett. 2015 Mar 17;590:47-51. doi: 10.1016/j.neulet.2015.01.062. Epub 2015 Jan 27.

PMID:
25636691
13.

Structural diversity of copper(II) complexes with N-(2-pyridyl)imidazolidin-2-ones(thiones) and their in vitro antitumor activity.

Balewski Ł, Sączewski F, Bednarski PJ, Gdaniec M, Borys E, Makowska A.

Molecules. 2014 Oct 23;19(10):17026-51. doi: 10.3390/molecules191017026.

14.

Fluorinated analogues of marsanidine, a highly α2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities.

Wasilewska A, Sączewski F, Hudson AL, Ferdousi M, Scheinin M, Laurila JM, Rybczyńska A, Boblewski K, Lehmann A.

Eur J Med Chem. 2014 Nov 24;87:386-97. doi: 10.1016/j.ejmech.2014.09.083. Epub 2014 Sep 28.

PMID:
25282262
15.

Vagotomy reveals the importance of the imidazoline receptors in the cardiovascular effects of marsanidine and 7-ME-marsanidine in rats.

Boblewski K, Lehmann A, Sączewski F, Kornicka A, Rybczyńska A.

Pharmacol Rep. 2014 Oct;66(5):874-9. doi: 10.1016/j.pharep.2014.05.009. Epub 2014 Jun 6.

PMID:
25149994
16.

Marsanidine and 7-Me-marsanidine, the new hypotensive imidazolines augment sodium and urine excretion in rats.

Wróblewska M, Kasprzyk J, Sączewski F, Kornicka A, Boblewski K, Lehmann A, Rybczyńska A.

Pharmacol Rep. 2013;65(4):1025-32.

17.

Biological activities of guanidine compounds, 2008 - 2012 update.

Sączewski F, Balewski Ł.

Expert Opin Ther Pat. 2013 Aug;23(8):965-95. doi: 10.1517/13543776.2013.788645. Epub 2013 Apr 25. Review.

PMID:
23617396
18.

Synthesis and biological activities of 2-[(heteroaryl)methyl]imidazolines.

Saczewski J, Hudson A, Scheinin M, Rybczynska A, Ma D, Saczewski F, Laird S, Laurila JM, Boblewski K, Lehmann A, Gu J, Watts H.

Bioorg Med Chem. 2012 Jan 1;20(1):108-16. doi: 10.1016/j.bmc.2011.11.025. Epub 2011 Nov 25.

PMID:
22172308
19.

3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the α(2)-adrenoceptor compared to the imidazoline I(1) receptor.

Sączewski F, Kornicka A, Hudson AL, Laird S, Scheinin M, Laurila JM, Rybczyńska A, Boblewski K, Lehmann A, Gdaniec M.

Bioorg Med Chem. 2011 Jan 1;19(1):321-9. doi: 10.1016/j.bmc.2010.11.020. Epub 2010 Nov 11.

PMID:
21129985
20.

Synthesis of novel aryl(heteroaryl)sulfonyl ureas of possible biological interest.

Saczewski F, Kuchnio A, Samsel M, Łobocka M, Kiedrowska A, Lisewska K, Saczewski J, Gdaniec M, Bednarski PJ.

Molecules. 2010 Feb 26;15(3):1113-26. doi: 10.3390/molecules15031113.

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