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Items: 1 to 20 of 27


Longitudinal PET Imaging of α7 Nicotinic Acetylcholine Receptors with [18F]ASEM in a Rat Model of Parkinson's Disease.

Vetel S, Vercouillie J, Buron F, Vergote J, Tauber C, Busson J, Chicheri G, Routier S, Sérrière S, Chalon S.

Mol Imaging Biol. 2019 Jul 8. doi: 10.1007/s11307-019-01400-y. [Epub ahead of print]


Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats.

Ouach A, Vercouillie J, Bertrand E, Rodrigues N, Pin F, Serriere S, Boiaryna L, Chartier A, Percina N, Tangpong P, Gulhan Z, Mothes C, Deloye JB, Guilloteau D, Page G, Suzenet F, Buron F, Chalon S, Routier S.

Eur J Med Chem. 2019 Oct 1;179:449-469. doi: 10.1016/j.ejmech.2019.06.049. Epub 2019 Jun 27.


Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives.

Iacob AT, Drăgan M, Ghețu N, Pieptu D, Vasile C, Buron F, Routier S, Giusca SE, Caruntu ID, Profire L.

Polymers (Basel). 2018 Jun 2;10(6). pii: E607. doi: 10.3390/polym10060607.


Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY.

Eur J Med Chem. 2019 Apr 15;168:58-77. doi: 10.1016/j.ejmech.2018.12.063. Epub 2019 Feb 13.


Formulation and Characterization of New Polymeric Systems Based on Chitosan and Xanthine Derivatives with Thiazolidin-4-One Scaffold.

Constantin SM, Buron F, Routier S, Vasincu IM, Apotrosoaei M, Lupașcu F, Confederat L, Tuchilus C, Constantin MT, Sava A, Profire L.

Materials (Basel). 2019 Feb 13;12(4). pii: E558. doi: 10.3390/ma12040558.


Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer.

Elie J, Vercouillie J, Arlicot N, Lemaire L, Bidault R, Bodard S, Hosselet C, Deloye JB, Chalon S, Emond P, Guilloteau D, Buron F, Routier S.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1-7. doi: 10.1080/14756366.2018.1501043.


Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1',2':1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions.

Ejjoummany A, Belaroussi R, El Hakmaoui A, Akssira M, Guillaumet G, Buron F, Routier S.

Molecules. 2018 Oct 23;23(11). pii: E2740. doi: 10.3390/molecules23112740.


A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism.

Laskaris P, Vicentefranqueira R, Helynck O, Jouvion G, Calera JA, du Merle L, Suzenet F, Buron F, de Sousa RA, Mansuy D, Cavaillon JM, Latgé JP, Munier-Lehmann H, Ibrahim-Granet O.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02510-17. doi: 10.1128/AAC.02510-17. Print 2018 Jun.


Synthesis of [1,3,4]Thiadiazolo[3',2':1,2]imidazo[4,5-c]quinolines including Pictet-Spengler Reaction and Exploration of Their C-2 Reactivity through SNAr.

Place M, Copin C, Apotrosoaei M, Constantin S, Vasincu IM, Profire L, Buron F, Routier S.

J Org Chem. 2017 Dec 15;82(24):13700-13707. doi: 10.1021/acs.joc.7b02565. Epub 2017 Nov 21.


Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model.

Foucault-Fruchard L, Doméné A, Page G, Windsor M, Emond P, Rodrigues N, Dollé F, Damont A, Buron F, Routier S, Chalon S, Antier D.

Neuroscience. 2017 Jul 25;356:52-63. doi: 10.1016/j.neuroscience.2017.05.019. Epub 2017 May 18.


Synthesis and biological evaluation of the new 1,3-dimethylxanthine derivatives with thiazolidine-4-one scaffold.

Constantin S, Lupascu FG, Apotrosoaei M, Vasincu IM, Lupascu D, Buron F, Routier S, Profire L.

Chem Cent J. 2017 Feb 1;11:12. doi: 10.1186/s13065-017-0241-0. eCollection 2017.


30ièmes Journées Franco-Belges de Pharmacochimie.

Aci-Sèche S, Buron F, Plé K, Robin L, Suzenet F, Routier S.

Pharmaceuticals (Basel). 2016 Nov 18;9(4). pii: E73.


Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl ester.

Pânzariu AT, Apotrosoaei M, Vasincu IM, Drăgan M, Constantin S, Buron F, Routier S, Profire L, Tuchilus C.

Chem Cent J. 2016 Feb 4;10:6. doi: 10.1186/s13065-016-0151-6. eCollection 2016.


A Pyridine-Based Ligand with Two Hydrazine Functions for Lanthanide Chelation: Remarkable Kinetic Inertness for a Linear, Bishydrated Complex.

Bonnet CS, Laine S, Buron F, Tircsó G, Pallier A, Helm L, Suzenet F, Tóth É.

Inorg Chem. 2015 Jun 15;54(12):5991-6003. doi: 10.1021/acs.inorgchem.5b00804. Epub 2015 Jun 1.


The azaindole framework in the design of kinase inhibitors.

Mérour JY, Buron F, Plé K, Bonnet P, Routier S.

Molecules. 2014 Nov 28;19(12):19935-79. doi: 10.3390/molecules191219935. Review.


Design, synthesis and the biological evaluation of new 1,3-thiazolidine-4-ones based on the 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one scaffold.

Apotrosoaei M, Vasincu IM, Dragan M, Buron F, Routier S, Profire L.

Molecules. 2014 Sep 4;19(9):13824-47. doi: 10.3390/molecules190913824.


Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of 2-(4-isobutylphenyl)propionic acid.

Vasincu IM, Apotrosoaei M, Panzariu AT, Buron F, Routier S, Profire L.

Molecules. 2014 Sep 18;19(9):15005-25. doi: 10.3390/molecules190915005.


PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of β-Amyloid Plaques.

Martins AF, Morfin JF, Kubíčková A, Kubíček V, Buron F, Suzenet F, Salerno M, Lazar AN, Duyckaerts C, Arlicot N, Guilloteau D, Geraldes CF, Tóth E.

ACS Med Chem Lett. 2013 Apr 15;4(5):436-40. doi: 10.1021/ml400042w. eCollection 2013 May 9.


New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway.

Nehmé R, Nehmé H, Saurat T, de-Tauzia ML, Buron F, Lafite P, Verrelle P, Chautard E, Morin P, Routier S, Bénédetti H.

Anal Bioanal Chem. 2014 Jun;406(15):3743-54. doi: 10.1007/s00216-014-7790-z. Epub 2014 May 11.


Design, synthesis, and biological activity of pyridopyrimidine scaffolds as novel PI3K/mTOR dual inhibitors.

Saurat T, Buron F, Rodrigues N, de Tauzia ML, Colliandre L, Bourg S, Bonnet P, Guillaumet G, Akssira M, Corlu A, Guillouzo C, Berthier P, Rio P, Jourdan ML, Bénédetti H, Routier S.

J Med Chem. 2014 Feb 13;57(3):613-31. doi: 10.1021/jm401138v. Epub 2014 Jan 21.


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