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Items: 1 to 20 of 22

1.

Isoquinolinequinone N-oxides as anticancer agents effective against drug resistant cell lines.

Kruschel RD, Buzid A, Khandavilli UBR, Lawrence SE, Glennon JD, McCarthy FO.

Org Biomol Chem. 2020 Jan 2. doi: 10.1039/c9ob02441g. [Epub ahead of print]

PMID:
31894828
2.

Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells.

Miller CM, O'Sullivan EC, McCarthy FO.

Pharmaceuticals (Basel). 2019 Jun 14;12(2). pii: E90. doi: 10.3390/ph12020090.

3.

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition.

Winfield HJ, Cahill MM, O'Shea KD, Pierce LT, Robert T, Ruchaud S, Bach S, Marchand P, McCarthy FO.

Bioorg Med Chem. 2018 Aug 7;26(14):4209-4224. doi: 10.1016/j.bmc.2018.07.012. Epub 2018 Jul 9.

PMID:
30026041
4.

Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates.

Cahill MM, O'Shea KD, Pierce LT, Winfield HJ, Eccles KS, Lawrence SE, McCarthy FO.

Pharmaceuticals (Basel). 2017 Jul 5;10(3). pii: E62. doi: 10.3390/ph10030062.

5.

The impact of storage conditions upon gentamicin coated antimicrobial implants.

Mullins ND, Deadman BJ, Moynihan HA, McCarthy FO, Lawrence SE, Thompson J, Maguire AR.

J Pharm Anal. 2016 Dec;6(6):374-381. doi: 10.1016/j.jpha.2016.05.002. Epub 2016 May 26.

6.

Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.

Smaill JB, Gonzales AJ, Spicer JA, Lee H, Reed JE, Sexton K, Althaus IW, Zhu T, Black SL, Blaser A, Denny WA, Ellis PA, Fakhoury S, Harvey PJ, Hook K, McCarthy FO, Palmer BD, Rivault F, Schlosser K, Ellis T, Thompson AM, Trachet E, Winters RT, Tecle H, Bridges A.

J Med Chem. 2016 Sep 8;59(17):8103-24. doi: 10.1021/acs.jmedchem.6b00883. Epub 2016 Aug 22.

PMID:
27491023
7.

Oxidation of sitosterol and transport of its 7-oxygenated products from different tissues in humans and ApoE knockout mice.

Schött HF, Baumgartner S, Husche C, Luister A, Friedrichs S, Miller CM, McCarthy FO, Plat J, Laufs U, Weingärtner O, Lütjohann D.

J Steroid Biochem Mol Biol. 2017 May;169:145-151. doi: 10.1016/j.jsbmb.2016.04.011. Epub 2016 Apr 27.

PMID:
27132025
8.

Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria.

Lehouritis P, Stanton M, McCarthy FO, Jeavons M, Tangney M.

J Control Release. 2016 Jan 28;222:9-17. doi: 10.1016/j.jconrel.2015.11.030. Epub 2015 Dec 2.

PMID:
26655063
9.

7-formyl-10-methylisoellipticine, a novel ellipticine derivative, induces mitochondrial reactive oxygen species (ROS) and shows anti-leukaemic activity in mice.

Russell EG, Guo J, O'Sullivan EC, O'Driscoll CM, McCarthy FO, Cotter TG.

Invest New Drugs. 2016 Feb;34(1):15-23. doi: 10.1007/s10637-015-0302-y. Epub 2015 Nov 12.

PMID:
26559431
10.

Local bacteria affect the efficacy of chemotherapeutic drugs.

Lehouritis P, Cummins J, Stanton M, Murphy CT, McCarthy FO, Reid G, Urbaniak C, Byrne WL, Tangney M.

Sci Rep. 2015 Sep 29;5:14554. doi: 10.1038/srep14554.

11.

7β-Hydroxysitosterol crosses the blood-brain barrier more favored than its substrate sitosterol in ApoE-/- mice.

Schött HF, Husche C, Friedrichs S, Miller CM, McCarthy FO, Laufs U, Plat J, Weingärtner O, Lütjohann D.

Steroids. 2015 Jul;99(Pt B):178-82. doi: 10.1016/j.steroids.2015.03.006. Epub 2015 Mar 17.

PMID:
25795151
12.

Recent advances in Phytosterol Oxidation Products.

O'Callaghan Y, McCarthy FO, O'Brien NM.

Biochem Biophys Res Commun. 2014 Apr 11;446(3):786-91. doi: 10.1016/j.bbrc.2014.01.148. Epub 2014 Jan 31. Review.

PMID:
24491535
13.

Synthesis and evaluation of novel ellipticines as potential anti-cancer agents.

Deane FM, O'Sullivan EC, Maguire AR, Gilbert J, Sakoff JA, McCluskey A, McCarthy FO.

Org Biomol Chem. 2013 Feb 28;11(8):1334-44. doi: 10.1039/c2ob27186a.

PMID:
23314103
14.

Synthesis and biological evaluation of novel isoellipticine derivatives and salts.

Miller CM, O'Sullivan EC, Devine KJ, McCarthy FO.

Org Biomol Chem. 2012 Oct 21;10(39):7912-21.

PMID:
22940706
15.

Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents.

Pierce LT, Cahill MM, Winfield HJ, McCarthy FO.

Eur J Med Chem. 2012 Oct;56:292-300. doi: 10.1016/j.ejmech.2012.08.002. Epub 2012 Aug 10.

PMID:
22910137
16.

Oxidized derivatives of dihydrobrassicasterol: cytotoxic and apoptotic potential in U937 and HepG2 cells.

Kenny O, O'Callaghan Y, O'Connell NM, McCarthy FO, Maguire AR, O'Brien NM.

J Agric Food Chem. 2012 Jun 13;60(23):5952-61. doi: 10.1021/jf204737e. Epub 2012 May 30.

PMID:
22594485
17.

Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells.

O'Callaghan Y, Kenny O, O'Connell NM, Maguire AR, McCarthy FO, O'Brien NM.

Biochimie. 2013 Mar;95(3):496-503. doi: 10.1016/j.biochi.2012.04.019. Epub 2012 Apr 26.

PMID:
22561884
18.

Cytotoxic and apoptotic effects of the oxidized derivatives of stigmasterol in the U937 human monocytic cell line.

O'Callaghan YC, Foley DA, O'Connell NM, McCarthy FO, Maguire AR, O'Brien NM.

J Agric Food Chem. 2010 Oct 13;58(19):10793-8. doi: 10.1021/jf1023017.

PMID:
20828195
19.

Synthesis and characterization of stigmasterol oxidation products.

Foley DA, O'Callaghan Y, O'Brien NM, McCarthy FO, Maguire AR.

J Agric Food Chem. 2010 Jan 27;58(2):1165-73. doi: 10.1021/jf9024745.

PMID:
20025271
20.

Computer simulations reveal a novel nucleotide-type binding orientation for ellipticine-based anticancer c-kit kinase inhibitors.

Thompson D, Miller C, McCarthy FO.

Biochemistry. 2008 Sep 30;47(39):10333-44. doi: 10.1021/bi801239u. Epub 2008 Aug 29.

PMID:
18754682

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