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Molecules. 2019 Aug 9;24(16). pii: E2891. doi: 10.3390/molecules24162891.

Flavonoids from Brazilian Cerrado: Biosynthesis, Chemical and Biological Profile.

Author information

1
Laboratório de Pesquisa em Biodiversidade (LaPeBio), Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil.
2
Câmpus de Ciências Exatas e Tecnológicas, Universidade Estadual de Goiás, Anápolis 75132-400, Goiás, Brazil.
3
Laboratory of Cheminformatics (LabChemIn), Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil.
4
Laboratório de Novos Materiais, Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil.
5
Laboratório de Pesquisas Avançadas e Geoprocesamento (LaPAGeo), Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil.
6
Laboratório de História Ambiental do Cerrado, Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil.
7
Laboratório de Pesquisa em Biodiversidade (LaPeBio), Centro Universitário de Anápolis-UniEVANGÉLICA, Anápolis 75083-515, Goiás, Brazil. lucimar.pinheiro@yahoo.com.br.

Abstract

Flavonoids are highly bioactive compounds with very low toxicity, which makes them attractive starting points in drug discovery. This study aims to provide information on plant species containing flavonoids, which are found in the Brazilian Cerrado. First, we present the characterization and plant diversity with emphasis on the families of flavonoid-producing plants, and then we describe the phenylpropanoid pathway which represents the flavonoids' main route biosynthesis-generally conserved in all species. Chemical structures and biological activities of flavonoids isolated from the Cerrado's plant species are also described based on examples from the relevant literature studies. Finally, research on the biodiversity of the Cerrado biome should be encouraged, due to the discovery of new sources of flavonoids which can provide several benefits to human health and the possibility of developing new drugs by the pharmaceutical industry.

KEYWORDS:

Brazilian Cerrado; biodiversity; biosynthesis; flavonoids

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