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Items: 1 to 20 of 35

1.

Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis.

Lachiondo-Ortega S, Mercado-Gómez M, Serrano-Maciá M, Lopitz-Otsoa F, Salas-Villalobos TB, Varela-Rey M, Delgado TC, Martínez-Chantar ML.

Cells. 2019 Dec 4;8(12). pii: E1575. doi: 10.3390/cells8121575. Review.

2.

SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets.

Cannito S, Foglia B, Villano G, Turato C, Delgado TC, Morello E, Pin F, Novo E, Napione L, Quarta S, Ruvoletto M, Fasolato S, Zanus G, Colombatto S, Lopitz-Otsoa F, Fernández-Ramos D, Bussolino F, Sutti S, Albano E, Martínez-Chantar ML, Pontisso P, Parola M.

Cancers (Basel). 2019 Dec 4;11(12). pii: E1933. doi: 10.3390/cancers11121933.

3.

SUMO-Binding Entities (SUBEs) as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer.

Lopitz-Otsoa F, Delgado TC, Lachiondo-Ortega S, Azkargorta M, Elortza F, Rodríguez MS, Martínez-Chantar ML.

J Vis Exp. 2019 Nov 1;(153). doi: 10.3791/60098.

PMID:
31736480
4.

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease.

Fernández-Tussy P, Fernández-Ramos D, Lopitz-Otsoa F, Simón J, Barbier-Torres L, Gomez-Santos B, Nuñez-Garcia M, Azkargorta M, Gutiérrez-de Juan V, Serrano-Macia M, Rodríguez-Agudo R, Iruzubieta P, Anguita J, Castro RE, Champagne D, Rincón M, Elortza F, Arslanow A, Krawczyk M, Lammert F, Kirchmeyer M, Behrmann I, Crespo J, Lu SC, Mato JM, Varela-Rey M, Aspichueta P, Delgado TC, Martínez-Chantar ML.

Mol Metab. 2019 Nov;29:40-54. doi: 10.1016/j.molmet.2019.08.008. Epub 2019 Aug 16.

5.

Post-translational modifiers of liver kinase B1/serine/threonine kinase 11 in hepatocellular carcinoma.

Delgado TC, Lopitz-Otsoa F, Martínez-Chantar ML.

J Hepatocell Carcinoma. 2019 Jun 6;6:85-91. doi: 10.2147/JHC.S169585. eCollection 2019.

6.

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer.

Zubiete-Franco I, García-Rodríguez JL, Lopitz-Otsoa F, Serrano-Macia M, Simon J, Fernández-Tussy P, Barbier-Torres L, Fernández-Ramos D, Gutiérrez-de-Juan V, López de Davalillo S, Carlevaris O, Beguiristain Gómez A, Villa E, Calvisi D, Martín C, Berra E, Aspichueta P, Beraza N, Varela-Rey M, Ávila M, Rodríguez MS, Mato JM, Díaz-Moreno I, Díaz-Quintana A, Delgado TC, Martínez-Chantar ML.

EBioMedicine. 2019 Feb;40:406-421. doi: 10.1016/j.ebiom.2018.12.031. Epub 2018 Dec 26.

7.

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.

Fernández-Ramos D, Fernández-Tussy P, Lopitz-Otsoa F, Gutiérrez-de-Juan V, Navasa N, Barbier-Torres L, Zubiete-Franco I, Simón J, Fernández AF, Arbelaiz A, Aransay AM, Lavín JL, Beraza N, Perugorria MJ, Banales JM, Villa E, Fraga MF, Anguita J, Avila MA, Berasain C, Iruzibieta P, Crespo J, Lu SC, Varela-Rey M, Mato JM, Delgado TC, Martínez-Chantar ML.

Cell Death Dis. 2018 Sep 20;9(10):958. doi: 10.1038/s41419-018-1014-y.

8.

Neddylation, a novel paradigm in liver cancer.

Delgado TC, Barbier-Torres L, Zubiete-Franco I, Lopitz-Otsoa F, Varela-Rey M, Fernández-Ramos D, Martínez-Chantar ML.

Transl Gastroenterol Hepatol. 2018 Jun 30;3:37. doi: 10.21037/tgh.2018.06.05. eCollection 2018. Review.

9.

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.

Barbier-Torres L, Iruzubieta P, Fernández-Ramos D, Delgado TC, Taibo D, Guitiérrez-de-Juan V, Varela-Rey M, Azkargorta M, Navasa N, Fernández-Tussy P, Zubiete-Franco I, Simon J, Lopitz-Otsoa F, Lachiondo-Ortega S, Crespo J, Masson S, McCain MV, Villa E, Reeves H, Elortza F, Lucena MI, Hernández-Alvarez MI, Zorzano A, Andrade RJ, Lu SC, Mato JM, Anguita J, Rincón M, Martínez-Chantar ML.

Nat Commun. 2017 Dec 12;8(1):2068. doi: 10.1038/s41467-017-01970-x.

10.

A morphological method for ammonia detection in liver.

Gutiérrez-de-Juan V, López de Davalillo S, Fernández-Ramos D, Barbier-Torres L, Zubiete-Franco I, Fernández-Tussy P, Simon J, Lopitz-Otsoa F, de Las Heras J, Iruzubieta P, Arias-Loste MT, Villa E, Crespo J, Andrade R, Lucena MI, Varela-Rey M, Lu SC, Mato JM, Delgado TC, Martínez-Chantar ML.

PLoS One. 2017 Mar 20;12(3):e0173914. doi: 10.1371/journal.pone.0173914. eCollection 2017.

11.

Deregulated neddylation in liver fibrosis.

Zubiete-Franco I, Fernández-Tussy P, Barbier-Torres L, Simon J, Fernández-Ramos D, Lopitz-Otsoa F, Gutiérrez-de Juan V, de Davalillo SL, Duce AM, Iruzubieta P, Taibo D, Crespo J, Caballeria J, Villa E, Aurrekoetxea I, Aspichueta P, Varela-Rey M, Lu SC, Mato JM, Beraza N, Delgado TC, Martínez-Chantar ML.

Hepatology. 2017 Feb;65(2):694-709. doi: 10.1002/hep.28933. Epub 2016 Dec 30.

12.

Evolution of SUMO Function and Chain Formation in Insects.

Ureña E, Pirone L, Chafino S, Pérez C, Sutherland JD, Lang V, Rodriguez MS, Lopitz-Otsoa F, Blanco FJ, Barrio R, Martín D.

Mol Biol Evol. 2016 Feb;33(2):568-84. doi: 10.1093/molbev/msv242. Epub 2015 Nov 4.

13.

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.

Zubiete-Franco I, García-Rodríguez JL, Martínez-Uña M, Martínez-Lopez N, Woodhoo A, Juan VG, Beraza N, Lage-Medina S, Andrade F, Fernandez ML, Aldámiz-Echevarría L, Fernández-Ramos D, Falcon-Perez JM, Lopitz-Otsoa F, Fernandez-Tussy P, Barbier-Torres L, Luka Z, Wagner C, García-Monzón C, Lu SC, Aspichueta P, Mato JM, Martínez-Chantar ML, Varela-Rey M.

J Hepatol. 2016 Feb;64(2):409-418. doi: 10.1016/j.jhep.2015.08.037. Epub 2015 Sep 21.

14.

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.

Barbier-Torres L, Beraza N, Fernández-Tussy P, Lopitz-Otsoa F, Fernández-Ramos D, Zubiete-Franco I, Varela-Rey M, Delgado TC, Gutiérrez V, Anguita J, Pares A, Banales JM, Villa E, Caballería J, Alvarez L, Lu SC, Mato JM, Martínez-Chantar ML.

Hepatology. 2015 Oct;62(4):1237-48. doi: 10.1002/hep.27959. Epub 2015 Jul 31.

15.

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.

Barbier-Torres L, Delgado TC, García-Rodríguez JL, Zubiete-Franco I, Fernández-Ramos D, Buqué X, Cano A, Gutiérrez-de Juan V, Fernández-Domínguez I, Lopitz-Otsoa F, Fernández-Tussy P, Boix L, Bruix J, Villa E, Castro A, Lu SC, Aspichueta P, Xirodimas D, Varela-Rey M, Mato JM, Beraza N, Martínez-Chantar ML.

Oncotarget. 2015 Feb 10;6(4):2509-23.

16.

PHD3-SUMO conjugation represses HIF1 transcriptional activity independently of PHD3 catalytic activity.

Núñez-O'Mara A, Gerpe-Pita A, Pozo S, Carlevaris O, Urzelai B, Lopitz-Otsoa F, Rodríguez MS, Berra E.

J Cell Sci. 2015 Jan 1;128(1):40-9. doi: 10.1242/jcs.151514. Epub 2014 Nov 6.

17.

Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity.

Lang V, Pallara C, Zabala A, Lobato-Gil S, Lopitz-Otsoa F, Farrás R, Hjerpe R, Torres-Ramos M, Zabaleta L, Blattner C, Hay RT, Barrio R, Carracedo A, Fernandez-Recio J, Rodríguez MS, Aillet F.

Mol Oncol. 2014 Jul;8(5):1026-42. doi: 10.1016/j.molonc.2014.04.002. Epub 2014 Apr 13.

18.

Scavenger receptors mediate the role of SUMO and Ftz-f1 in Drosophila steroidogenesis.

Talamillo A, Herboso L, Pirone L, Pérez C, González M, Sánchez J, Mayor U, Lopitz-Otsoa F, Rodriguez MS, Sutherland JD, Barrio R.

PLoS Genet. 2013 Apr;9(4):e1003473. doi: 10.1371/journal.pgen.1003473. Epub 2013 Apr 18.

19.

Analysis of SUMOylated proteins using SUMO-traps.

Da Silva-Ferrada E, Xolalpa W, Lang V, Aillet F, Martin-Ruiz I, de la Cruz-Herrera CF, Lopitz-Otsoa F, Carracedo A, Goldenberg SJ, Rivas C, England P, Rodríguez MS.

Sci Rep. 2013;3:1690. doi: 10.1038/srep01690.

20.

Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity.

Aillet F, Lopitz-Otsoa F, Egaña I, Hjerpe R, Fraser P, Hay RT, Rodriguez MS, Lang V.

PLoS One. 2012;7(12):e51672. doi: 10.1371/journal.pone.0051672. Epub 2012 Dec 20.

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