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Items: 1 to 20 of 28


Reversible renal glomerular dysfunction in guinea pigs exposed to glutaraldehyde-polymerized cell-free hemoglobin.

Zhang X, Williams MC, Rentsendorj O, D'Agnillo F.

Toxicology. 2018 Jun 1;402-403:37-49. doi: 10.1016/j.tox.2018.04.005. Epub 2018 Apr 22.


Comprehensive Biochemical and Biophysical Characterization of Hemoglobin-Based Oxygen Carrier Therapeutics: All HBOCs Are Not Created Equally.

Meng F, Kassa T, Jana S, Wood F, Zhang X, Jia Y, D'Agnillo F, Alayash AI.

Bioconjug Chem. 2018 May 16;29(5):1560-1575. doi: 10.1021/acs.bioconjchem.8b00093. Epub 2018 Apr 2.


Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5.

Huang LY, Stuart C, Takeda K, D'Agnillo F, Golding B.

PLoS One. 2016 Aug 9;11(8):e0160875. doi: 10.1371/journal.pone.0160875. eCollection 2016.


Transcriptional Suppression of Renal Antioxidant Enzyme Systems in Guinea Pigs Exposed to Polymerized Cell-Free Hemoglobin.

Rentsendorj O, Zhang X, Williams MC, Buehler PW, D'Agnillo F.

Toxics. 2016;4(1). pii: 6. Epub 2016 Feb 19.


Transcriptional Suppression of Renal Antioxidant Enzyme Systems in Guinea Pigs Exposed to Polymerized Cell-Free Hemoglobin.

Rentsendorj O, Zhang X, Williams MC, Buehler PW, D'Agnillo F.

Toxics. 2016 Feb 19;4(1). pii: E6. doi: 10.3390/toxics4010006.


1918 pandemic influenza virus and Streptococcus pneumoniae co-infection results in activation of coagulation and widespread pulmonary thrombosis in mice and humans.

Walters KA, D'Agnillo F, Sheng ZM, Kindrachuk J, Schwartzman LM, Kuestner RE, Chertow DS, Golding BT, Taubenberger JK, Kash JC.

J Pathol. 2016 Jan;238(1):85-97. doi: 10.1002/path.4638. Epub 2015 Oct 14.


Sodium nitrite potentiates renal oxidative stress and injury in hemoglobin exposed guinea pigs.

Baek JH, Zhang X, Williams MC, Hicks W, Buehler PW, D'Agnillo F.

Toxicology. 2015 Jul 3;333:89-99. doi: 10.1016/j.tox.2015.04.007. Epub 2015 Apr 17.


Extracellular Hb enhances cardiac toxicity in endotoxemic guinea pigs: protective role of haptoglobin.

Baek JH, Zhang X, Williams MC, Schaer DJ, Buehler PW, D'Agnillo F.

Toxins (Basel). 2014 Mar 31;6(4):1244-59. doi: 10.3390/toxins6041244.


Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.

D'Agnillo F, Williams MC, Moayeri M, Warfel JM.

PLoS One. 2013 Apr 23;8(4):e62576. doi: 10.1371/journal.pone.0062576. Print 2013.


Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

Baek JH, D'Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW.

J Clin Invest. 2012 Apr;122(4):1444-58. doi: 10.1172/JCI59770. Epub 2012 Mar 26.


Anthrax lethal toxin-mediated disruption of endothelial VE-cadherin is attenuated by inhibition of the Rho-associated kinase pathway.

Warfel JM, D'Agnillo F.

Toxins (Basel). 2011 Oct;3(10):1278-93. doi: 10.3390/toxins3101278. Epub 2011 Oct 20.


Sodium nitrite induces acute central nervous system toxicity in guinea pigs exposed to systemic cell-free hemoglobin.

Buehler PW, Butt OI, D'Agnillo F.

Biochem Biophys Res Commun. 2011 Jun 10;409(3):412-7. doi: 10.1016/j.bbrc.2011.05.009. Epub 2011 May 14.


Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin.

Butt OI, Buehler PW, D'Agnillo F.

Am J Pathol. 2011 Mar;178(3):1316-28. doi: 10.1016/j.ajpath.2010.12.006.


Hemoglobin-based oxygen carriers: From mechanisms of toxicity and clearance to rational drug design.

Buehler PW, D'Agnillo F, Schaer DJ.

Trends Mol Med. 2010 Oct;16(10):447-57. doi: 10.1016/j.molmed.2010.07.006. Epub 2010 Aug 13. Review.


Toxicological consequences of extracellular hemoglobin: biochemical and physiological perspectives.

Buehler PW, D'Agnillo F.

Antioxid Redox Signal. 2010 Feb;12(2):275-91. doi: 10.1089/ars.2009.2799. Review.


Differential induction of renal heme oxygenase and ferritin in ascorbate and nonascorbate producing species transfused with modified cell-free hemoglobin.

Butt OI, Buehler PW, D'Agnillo F.

Antioxid Redox Signal. 2010 Feb;12(2):199-208. doi: 10.1089/ars.2009.2798.


Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.

Boretti FS, Buehler PW, D'Agnillo F, Kluge K, Glaus T, Butt OI, Jia Y, Goede J, Pereira CP, Maggiorini M, Schoedon G, Alayash AI, Schaer DJ.

J Clin Invest. 2009 Aug;119(8):2271-80. doi: 10.1172/JCI39115. Epub 2009 Jul 20.


Anthrax lethal toxin enhances IkappaB kinase activation and differentially regulates pro-inflammatory genes in human endothelium.

Warfel JM, D'Agnillo F.

J Biol Chem. 2009 Sep 18;284(38):25761-71. doi: 10.1074/jbc.M109.036970. Epub 2009 Jul 20.


Acellular haemoglobin attenuates hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes in haemodiluted rats.

Manalo DJ, Buehler PW, Baek JH, Butt O, D'agnillo F, Alayash AI.

Biochem J. 2008 Sep 15;414(3):461-9. doi: 10.1042/BJ20080313.


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