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Items: 16

1.

Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.

Guimarães DSM, de Sousa Luz LS, do Nascimento SB, Silva LR, de Miranda Martins NR, de Almeida HG, de Souza Reis V, Maluf SEC, Budu A, Marinho JA, Abramo C, Carmona AK, da Silva MG, da Silva GR, Kemmer VM, Butera AP, Ribeiro-Viana RM, Gazarini ML, Júnior CSN, Guimarães L, Dos Santos FV, de Castro WV, Viana GHR, de Brito CFA, de Pilla Varotti F.

Eur J Pharm Sci. 2019 Oct 1;138:105015. doi: 10.1016/j.ejps.2019.105015. Epub 2019 Jul 22.

PMID:
31344442
2.

Target-Guided Synthesis and Antiplasmodial Evaluation of a New Fluorinated 3-Alkylpyridine Marine Alkaloid Analog.

Barbosa CS, Guimarães DSM, Gonçalves AMMN, Barbosa MCDS, Alves E Costa ML, Nascimento Júnior CS, Guimarães L, Ribeiro-Viana RM, Dos Santos FV, Alves de Brito CF, de Pilla Varotti F, Ribeiro Viana GH.

ACS Omega. 2017 Nov 30;2(11):8264-8272. doi: 10.1021/acsomega.7b01302. Epub 2017 Nov 21.

3.

Synthesis and evaluation of the mutagenicity of 3-alkylpyridine marine alkaloid analogues with anticancer potential.

Barbosa MCS, de Souza Barbosa C, de Oliveira JT, Moreira NCS, de Miranda Martins NR, Alves Gomes GK, Caldeira CA, Alves E Costa ML, Martins Guimarães DS, Guimarães L, Nascimento CS Jr, de Pilla Varotti F, Ribeiro Viana GH, Santos FVD.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Jan;825:31-39. doi: 10.1016/j.mrgentox.2017.11.006. Epub 2017 Nov 24.

PMID:
29307373
4.

Digoxin reduces the mutagenic effects of Mitomycin C in human and rodent cell lines.

de Oliveira JT, Barbosa MCDS, de Camargos LF, da Silva IVG, Varotti FP, da Silva LM, Moreira LM, Lyon JP, Dos Santos VJDSV, Dos Santos FV.

Cytotechnology. 2017 Aug;69(4):699-710. doi: 10.1007/s10616-017-0078-3. Epub 2017 Mar 20.

5.

New 3-alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44+/high /CD24-/low subset of triple-negative breast cancer cell line.

de Lima AB, Barbosa CS, Gonçalves AMMN, Santos FVD, Viana GHR, Varotti FP, Silva LM.

Chem Biol Drug Des. 2017 Jul;90(1):5-11. doi: 10.1111/cbdd.12923. Epub 2017 Feb 7.

PMID:
27995747
6.

Tapirira guianensis Aubl. Extracts Inhibit Proliferation and Migration of Oral Cancer Cells Lines.

Silva-Oliveira RJ, Lopes GF, Camargos LF, Ribeiro AM, Santos FV, Severino RP, Severino VG, Terezan AP, Thomé RG, Santos HB, Reis RM, Ribeiro RI.

Int J Mol Sci. 2016 Nov 8;17(11). pii: E1839.

7.

Leishmanicidal, antiproteolytic, and mutagenic evaluation of alkyltriazoles and alkylphosphocholines.

Gontijo VS, Espuri PF, Alves RB, de Camargos LF, Santos FV, de Souza Judice WA, Marques MJ, Freitas RP.

Eur J Med Chem. 2015 Aug 28;101:24-33. doi: 10.1016/j.ejmech.2015.06.005. Epub 2015 Jun 5.

PMID:
26112378
8.

Effect of eosinophil cationic protein on human oral squamous carcinoma cell viability.

DE Lima PO, Dos Santos FV, Oliveira DT, DE Figueiredo RC, Pereira MC.

Mol Clin Oncol. 2015 Mar;3(2):353-356. Epub 2014 Dec 16.

9.

Effects of digoxin and Na, K-ATPase immunoexpression on human oral squamous carcinomas.

Chaves AL, De Lima PO, Soares JM, Dos Santos HB, Silva AG, Muniz LV, Dos Santos FV, Pereira MC, De Azambuja Ribeiro RI, Barbosa LA.

Anticancer Res. 2014 Oct;34(10):5397-403.

PMID:
25275034
10.

Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity.

Gonçalves AM, de Lima AB, da Silva Barbosa MC, de Camargos LF, de Oliveira JT, de Souza Barbosa C, Villar JA, Costa AC, Silva IV, Silva LM, de Pilla Varotti F, dos Santos FV, Viana GH.

Mar Drugs. 2014 Jul 31;12(8):4361-78. doi: 10.3390/md12084361.

11.

Evaluation of healing wound and genotoxicity potentials from extracts hydroalcoholic of Plantago major and Siparuna guianensis.

Thomé RG, dos Santos HB, dos Santos FV, da Silva Oliveira RJ, de Camargos LF, Pereira MN, Longatti TR, Souto CM, Franco CS, de Oliveira Aquino Schüffner R, Ribeiro RI.

Exp Biol Med (Maywood). 2012 Dec;237(12):1379-86. doi: 10.1258/ebm.2012.012139.

PMID:
23354396
12.

In vitro photodynamic therapy against Foncecaea pedrosoi and Cladophialophora carrionii.

Lyon JP, Moreira LM, de Carvalho VS, dos Santos FV, de Lima CJ, de Resende MA.

Mycoses. 2013 Mar;56(2):157-61. doi: 10.1111/j.1439-0507.2012.02226.x. Epub 2012 Jul 23.

PMID:
22816425
13.

Photodynamic therapy for pathogenic fungi.

Lyon JP, Moreira LM, de Moraes PC, dos Santos FV, de Resende MA.

Mycoses. 2011 Sep;54(5):e265-71. doi: 10.1111/j.1439-0507.2010.01966.x. Epub 2011 Jun 14. Review.

PMID:
21672042
14.

Inhibition of virulence factors of Candida spp. by different surfactants.

Lyon JP, dos Santos FV, de Moraes PC, Moreira LM.

Mycopathologia. 2011 Feb;171(2):93-101. doi: 10.1007/s11046-010-9351-0. Epub 2010 Jul 31.

PMID:
20680686
15.

Modulatory effect of Byrsonima basiloba extracts on the mutagenicity of certain direct and indirect-acting mutagens in Salmonella typhimurium assays.

Lira Wde M, dos Santos FV, Sannomiya M, Rodrigues CM, Vilegas W, Varanda EA.

J Med Food. 2008 Mar;11(1):111-9. doi: 10.1089/jmf.2007.553.

PMID:
18361746
16.

Protective effect of DCTN (trans-dehydrocrotonin) against induction of micronuclei and apoptosis by different mutagenic agents in vitro.

Poersch A, dos Santos FV, Maciel MA, de Câmara JK, de Castro Dantas TN, de Syllos Cólus IM.

Mutat Res. 2007 Apr 20;629(1):14-23. Epub 2007 Jan 10.

PMID:
17276134

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