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Items: 1 to 20 of 43

1.

Combination ANGPTL3, PCSK9 and statin therapy drives remarkable reductions in hyperlipidemia and atherosclerosis in a mouse model.

Hurt-Camejo E.

J Lipid Res. 2020 Jan 24. pii: jlr.C120000650. doi: 10.1194/jlr.C120000650. [Epub ahead of print] No abstract available.

2.

3-Hydroxyanthralinic acid Metabolism Controls the Hepatic Srebp/Lipoprotein axis, Inhibits Inflammasome Activation in Macrophages, and Decreases Atherosclerosis in LDLR-/- Mice.

Berg M, Polyzos KA, Agardh H, Baumgartner R, Forteza MJ, Kareinen I, Gisterå A, Bottcher G, Hurt-Camejo E, Hansson GK, Ketelhuth DFJ.

Cardiovasc Res. 2019 Oct 7. pii: cvz258. doi: 10.1093/cvr/cvz258. [Epub ahead of print]

PMID:
31589306
3.

Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia.

Sokolov V, Helmlinger G, Nilsson C, Zhudenkov K, Skrtic S, Hamrén B, Peskov K, Hurt-Camejo E, Jansson-Löfmark R.

J Lipid Res. 2019 Sep;60(9):1610-1621. doi: 10.1194/jlr.M092486. Epub 2019 Jul 10.

4.

Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease.

Akinkuolie AO, Lawler PR, Chu AY, Caulfield M, Mu J, Ding B, Nyberg F, Glynn RJ, Ridker PM, Hurt-Camejo E, Chasman DI, Mora S.

Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1182-1190. doi: 10.1161/ATVBAHA.118.311894.

PMID:
31070471
5.

Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid.

Giordanetto F, Knerr L, Nordberg P, Pettersen D, Selmi N, Beisel HG, de la Motte H, Månsson Å, Dahlström M, Broddefalk J, Saarinen G, Klingegård F, Hurt-Camejo E, Rosengren B, Wikström J, Wågberg M, Brengdahl J, Rohman M, Sandmark J, Åkerud T, Roth RG, Jansen F, Ahlqvist M.

ACS Med Chem Lett. 2018 Jun 23;9(7):600-605. doi: 10.1021/acsmedchemlett.7b00507. eCollection 2018 Jul 12.

6.

Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors.

Knerr L, Giordanetto F, Nordberg P, Pettersen D, Selmi N, Beisel HG, de la Motte H, Olsson T, Perkins TDJ, Herslöf M, Månsson Å, Dahlström M, Starke I, Broddefalk J, Saarinen G, Klingegård F, Hurt-Camejo E, Rosengren B, Brengdahl J, Jansen F, Rohman M, Sandmark J, Hallberg K, Åkerud T, Roth RG, Ahlqvist M.

ACS Med Chem Lett. 2018 Jun 23;9(7):594-599. doi: 10.1021/acsmedchemlett.7b00505. eCollection 2018 Jul 12.

7.

Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis.

Aldi S, Matic LP, Hamm G, van Keulen D, Tempel D, Holmstrøm K, Szwajda A, Nielsen BS, Emilsson V, Ait-Belkacem R, Lengquist M, Paulsson-Berne G, Eriksson P, Lindeman JHN, Gool AJ, Stauber J, Hedin U, Hurt-Camejo E.

Mol Ther Methods Clin Dev. 2018 Jun 27;10:17-28. doi: 10.1016/j.omtm.2018.05.003. eCollection 2018 Sep 21.

8.
9.
10.

Does statins promote vascular calcification in chronic kidney disease?

Chen Z, Qureshi AR, Parini P, Hurt-Camejo E, Ripsweden J, Brismar TB, Barany P, Jaminon AM, Schurgers LJ, Heimbürger O, Lindholm B, Stenvinkel P.

Eur J Clin Invest. 2017 Feb;47(2):137-148. doi: 10.1111/eci.12718.

PMID:
28036114
11.

Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease.

Giordanetto F, Pettersen D, Starke I, Nordberg P, Dahlström M, Knerr L, Selmi N, Rosengren B, Larsson LO, Sandmark J, Castaldo M, Dekker N, Karlsson U, Hurt-Camejo E.

ACS Med Chem Lett. 2016 Aug 9;7(10):884-889. eCollection 2016 Oct 13.

12.

Suppression of abdominal aortic aneurysm formation by AR-R17779, an agonist for the α7 nicotinic acetylcholine receptor.

Watanabe A, Ichiki T, Kojima H, Takahara Y, Hurt-Camejo E, Michaëlsson E, Sankoda C, Ikeda J, Inoue E, Tokunou T, Kitamoto S, Sunagawa K.

Atherosclerosis. 2016 Jan;244:113-20. doi: 10.1016/j.atherosclerosis.2015.11.006. Epub 2015 Nov 17.

PMID:
26613536
13.

Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism.

Gnocchi D, Pedrelli M, Hurt-Camejo E, Parini P.

Biology (Basel). 2015 Feb 5;4(1):104-32. doi: 10.3390/biology4010104. Review.

14.

Stimulation of α7 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice.

Hashimoto T, Ichiki T, Watanabe A, Hurt-Camejo E, Michaëlsson E, Ikeda J, Inoue E, Matsuura H, Tokunou T, Kitamoto S, Sunagawa K.

Vascul Pharmacol. 2014 May-Jun;61(2-3):49-55. doi: 10.1016/j.vph.2014.03.006. Epub 2014 Mar 29.

PMID:
24685818
15.

Limits of Mendelian randomization analyses in selection of secretory phospholipase A2-IIA as a valid therapeutic target for prevention of cardiovascular disease.

Rosenson RS, Hurt-Camejo E.

J Am Coll Cardiol. 2014 Mar 11;63(9):942-3. doi: 10.1016/j.jacc.2013.09.074. Epub 2013 Dec 4. No abstract available.

16.

Macrophages, extracellular matrix, and lipoproteins in arterial cholesterol balance.

Camejo G, Hurt-Camejo E.

J Lipid Res. 2014 Jan;55(1):1-3. doi: 10.1194/jlr.E045732. Epub 2013 Nov 19. No abstract available.

17.

Expression of type IIA secretory phospholipase A2 inhibits cholesteryl ester transfer protein activity in transgenic mice.

Hurt-Camejo E, Gautier T, Rosengren B, Dikkers A, Behrendt M, Grass DS, Rader DJ, Tietge UJ.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2707-14. doi: 10.1161/ATVBAHA.113.301410. Epub 2013 Oct 10.

PMID:
24115030
18.

HDL2 interferes with LDL association with arterial proteoglycans: a possible athero-protective effect.

Umaerus M, Rosengren B, Fagerberg B, Hurt-Camejo E, Camejo G.

Atherosclerosis. 2012 Nov;225(1):115-20. doi: 10.1016/j.atherosclerosis.2012.08.040. Epub 2012 Sep 13.

PMID:
22999079
19.

Phospholipase A2 enzymes and the risk of atherosclerosis.

Rosenson RS, Hurt-Camejo E.

Eur Heart J. 2012 Dec;33(23):2899-909. doi: 10.1093/eurheartj/ehs148. Epub 2012 Jul 15. Review.

PMID:
22802388
20.

Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits.

Zhang J, Yu Y, Nakamura K, Koike T, Waqar AB, Zhang X, Liu E, Nishijima K, Kitajima S, Shiomi M, Qi Z, Yu J, Graham MJ, Crooke RM, Ishida T, Hirata K, Hurt-Camejo E, Chen YE, Fan J.

J Atheroscler Thromb. 2012;19(3):213-26. Epub 2012 Jan 12.

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